Visitors since August 2006
*Disclaimer: *These pages are my personal pages. The opinions expressed here, may or may not correspond to those of the Laboratory of Molecular Biology, or the Medical Research Council.*
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Sarath Chandra Janga, PhD
Publications in Peer-reviewed Journals:
• Conservation of adjacency as evidence of paralogous operons (PDF) (PUBMED) • Nebulon: a system for the inference of functional relationships of gene products from the rearrangement of predicted operons (PDF) (PUBMED) (Supplementary Material) (Web interface of Nebulon) • The network of transcriptional interactions imposes linear constrains in the genome (PDF) (PUBMED ) • Internal sensing machinery directs the activity of the regulatory network in Escherichia coli (PDF) (PUBMED) (Supplementary Material) Víctor González, Rosa I. Santamaría, Patricia Bustos, Ismael Hernández-González, Arturo Medrano-Soto, Gabriel Moreno-Hagelsieb, Sarath Chandra Janga , Miguel A. Ramírez, Verónica Jim énez-Jacinto, Julio Collado-Vides and Guillermo Dávila Proc. Natl. Acad. Sci. U S A. 103(10): 3834-9, 2006 • Operons and the effect of genome redundancy in deciphering functional relationships using phylogenetic profiles (PDF) (PUBMED) Sarath Chandra Janga * , Warren F. Lamboy, Araceli M. Huerta and Gabriel Moreno-Hagelsieb Nucleic Acids Research, 2006 Vol.34, No. 14, 3980-3987 • Bacterial regulatory networks are extremely flexible in evolution (PDF) (PUBMED) (Supplementary Material) • Identification and analysis of DNA-binding Transcription Factors in Bacillus subtilis and other Firmicutes- A genomic approach
(PDF) (PUBMED) (Supplementary Material available online at BMC genomics) • Prediction and evolution of transcription factors and their evolutionary families in prokaryotes (PDF) • Internal versus external effector and transcription factor gene pairs differ in their relative chromosomal position in Escherichia coli
(PDF) (PUBMED) (Supplementary Material) • Conservation of Transcriptional Sensing Systems in prokarya: A perspective from Escherichia coli (PDF) (PUBMED) • Operome: A comprehensive resource of predicted operon structures in complete prokaryotic genomes • Highlights from the Third International Society for Computational Biology Student Council Symposium (PDF) (PUBMED) • Structure and evolution of gene regulatory networks in microbial genomes (PDF) (PUBMED) • Co-ordination logic of sensing machinery in the transcriptional regulatory network of Escherichia coli (PDF) (PUBMED) • Ten simple rules for organising a successful scientific meeting (PDF) (PUBMED) • Functional organization of E. coli transcriptional regulatory network (PDF) (PUBMED) • Transcriptional regulation constrains the organization of genes on eukaryotic chromosomes (PDF) (PUBMED) • Eukaryotic gene regulation in three dimensions and its impact on genome evolution (PDF) (PUBMED) • Transcript stability in the protein interaction network of Escherichia coli (PDF) (PUBMED) • Highlights from the Fourth International Society for Computational Biology Student Council Symposium (PDF) (PUBMED) • Network approaches for linking metabolism with environment (PDF) (PUBMED) • Transcriptional regulation shapes the organization of genes on bacterial chromosomes (PDF) (PUBMED) • A global functional atlas of Escherichia coli encopassing the previously uncharacterized protein repertoire (PDF) (PUBMED) • Structural coupling between RNA polymerase composition and DNA supercoiling in coordinating transcription: a global role for the omega subunit? • Plasticity of transcriptional machinery in bacteria is increased by the repertoire of regulatory families
(PDF) (PUBMED) • Structure and organization of drug-target networks : Insights from genomic approaches for drug discovery (PDF) (PUBMED) • Scaling relationship in the gene content of transcriptional machinery in bacteria (PDF) (PUBMED) • Dissecting the expression dynamics of RNA-binding proteins in post-transcriptional regulatory networks (PDF) (PUBMED) • Interfacing systems biology and synthetic biology (PDF) (PUBMED) • Identification and genomic analysis of transcription factors in archaeal genomes exemplifies their functional architecture and evolutionary origin (PDF) (PUBMED) • Dissecting the expression patterns of transcription factors across conditions using an integrated network-based approach (PDF) (PUBMED) • Polypharmacological approaches to fight antibacterial resistance : Insights from drug-target networks • Transcriptional profiling of fetal hypothalamic TRH neurons • Genome-wide analysis of RNA decay patterns during early Drosophila development (PDF) (PUBMED) • A screen for RNA-binding proteins in yeast indicates dual functions for many enzymes (PDF) (PUBMED) • Network-based function prediction and interactomics: the case for metabolic enzymes (PDF) (PUBMED) • Interplay between post-transcriptional and post-translational interactions of RNA-binding proteins (PDF) (PUBMED) • Dissecting the interactome of RNA-binding proteins in post-transcriptional regulatory networks • Genome organization and transcriptional control in archaea • Intrinsic modularity in the genomic organization of eubacterial transcription factors
Book chapters : • Sarath Chandra Janga * and M. Madan Babu • Sarath Chandra Janga * • Sarath Chandra Janga * and
Gabriel Moreno-Hagelsieb • Sarath Chandra Janga * and Nitish Mittal • Sarath Chandra Janga * and Swati Vallabhaneni
Posters presented or co-authored: • Keystone meeting on 'Biomolecular Interaction Networks: Function and Disease' (2010) ' Dissecting the expression dynamics of RNA-binding proteins in post-transcriptional networks ' • CSHL meeting on 'Systems Biology: Global Regulation of Gene Expression' (2010) ' Systematic identification of RNA-binding proteins in yeast suggests dual functions for enzymes ' • Proteins and their networks meeting, Spetses, Greece (2009) ' Dissecting the expression dynamics of RNA-binding proteins in post-transcriptional networks ' • Cambridge Life Sciences symposium (CamLS) (2008) ' Transcriptional regulation constrains genome organization ' • Intelligent Systems for Molecular Biology (ISMB) (2008) ' Prokaryotic-wide gold standards and phylogenetic profiles ' • First Portuguese Forum on Computational Biology (2008) ' Insights into bivalent domains in murine stem cells ' • MRC-Laboratory of Molecular Biology graduate student symposium, Cambridge (2008) ' Transcriptional regulatory complexity constraints genome organization in eukaryotic organisms ' • Sanger-Cambridge Phd Symposium (Annual graduate symposium in biological sciences at Cambridge University) (2008) ' Evidence for the influence of transcriptional regulation in shaping the organization of genes in eukaryotic organisms ' • Intelligent Systems for Molecular Biology (ISMB) (2006) ' Plasticity of transcriptional regulatory machinery revealed from a comparison of complete regulatory reportoires. ' (Poster as PNG image) • International Conference on Systems Biology ( ICSB) (2005) ' Understanding operon recombinations in multi-replicon genomes: A perspective from Rhizobium etli .' (Poster as PNG image) • International Conference on Systems Biology ( ICSB) (2005) ' Internal Sensing Machinery directs the activity of the regulatory network in Escherichia coli .' (Poster as PNG image) • Arrowhead Conference, California , September 2004 & ISMB (2005) ' Nebulon: a system for the inference of functional relationships of gene products from the recombination of predicted operons ' (Poster as PNG image) • RECOMB (2005) ' No evidence for relation between co-regulation and transcriptional regulatory interactions in the evolution of regulatory networks.' (Poster as PNG image) • 6 th European Nitrogen Fixation Conference (2004) ' The Complete Genome Sequence of Rhizobium etli.' (Poster as PNG image) • Intelligent Systems for Molecular Biology (ISMB) ( 2004) ' Gene Ontology Network of Interactions among Operons in E.coli and B.subtilis '(Poster as PNG image) • Intelligent Systems for Molecular Biology (ISMB) (2004) ' Finding modules using network motifs as building blocks ' (Poster as PNG image) • Intelligent Systems for Molecular Biology (ISMB) (2004) ' Inference of Biological Modules in Escherichia coli Regulatory Network.' (Poster as PNG image) • HUGO Human Genome Meeting, Cancun , Mexico (2003) ' A Study of Paralogous Operons ' (Poster as PNG image) • Biohorizon 2003, India ' Gene Order Conservation in S. cerevisiae ' (adjudged the best poster)
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Visitors since August 2006
*Disclaimer: *These pages are my personal pages. The opinions expressed here, may or may not correspond to those of the Laboratory of Molecular Biology, or the Medical Research Council.*