Dihydro Orotate Dehydrogenase

PDB code: 2dor
E.C. Number: 1.3.3.1
Oligomeric unit: homodimer
No of residues: 311
Topology diagram:


PDB
SCOP
CATH
IBM-JENA
MMDB
FSSP
Relibase


Ramachandran Phi Psi values:

Global summary of BLAST search:

QUERY= Submission, 311 bases, 73DC9F76 checksum. 

                        |=============================================|311
>PYDA_LACLC       1524  1 --------------------------------------------- (PYRDA)DIHYDROOROTATE DEHYDROGENASE A (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE A) (DHODEHASE A) (DHODASE A) (DHOD A).[Lactococcus lactis]
>Q9CFC9           1475  1 --------------------------------------------- (PYDA)DIHYDROOROTATE DEHYDROGENASE A (EC 1.3.3.1).[Lactococcus lactis]
>PYRD_YEAST       1106  1 --------------------------------------------- (URA1..)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE).[Saccharomyces cerevisiae]
>PYRD_STRPN       1023  1 --------------------------------------------  (PYRD..)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Streptococcus pneumoniae]
>O76140          -1200031434  1  -------------------------------------------- (DHO..)DIHYDROOROTATE OXIDASE.[Trypanosoma cruzi]
>Q9NL74          -1198932568  1 --------------------------------------------- (PYR4)DIHYDROOROTATE DEHYDROGENASE.[Leishmania mexicana amazonensis]
>P96047            456  1                          -------------------  (PYRD)HSTH GENE (FRAGMENT).[Streptococcus thermophilus]
>Q9LAN0            380  1                            -----------------  (PYRD)DIHYDROOROTATE DEHYDROGENASE (FRAGMENT).[Streptococcus gordonii]
>PYRD_PYRAB      47043717  1 -------------------------------------------   (PYRD..)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Pyrococcus abyssi]
>PYRD_PYRHO      -1089746909  1 -------------------------------------------   (PYRD..)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Pyrococcus horikoshii]
>PYRD_METTH      -749991519  1 -------------------------------------------   (PYRD..)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Methanobacterium thermoautotrophicum]
>Q9HL35          -272319028  1 -------------------------------------------   (TA0404)DIHYDROOROTATE DEHYDROGENASE B RELATED PROTEIN.[Thermoplasma acidophilum]
>PYRD_METJA      1113328029  1 ------------------------------------------    (PYRD..)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Methanococcus jannaschii]
>Q9CFW8          2134632619  1  -------------------------------------------  (PYDB)DIHYDROOROTATE DEHYDROGENASE B (EC 1.3.3.1).[Lactococcus lactis]
>Q9K9W1          415479696  1  ------------------------------------------   (PYRD)DIHYDROOROTATE DEHYDROGENASE.[Bacillus halodurans]
>PYRD_BACSU      8497984  1 -------------------------------------------   (PYRD..)DIHYDROOROTATE DEHYDROGENASE, CATALYTIC SUBUNIT (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Bacillus subtilis]
>PYDB_LACLC      2134632605  1  -------------------------------------------  (PYRDB)DIHYDROOROTATE DEHYDROGENASE B, CATALYTIC SUBUNIT (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE B) (DHODEHASE B) (DHODASE B) (DHOD B).[Lactococcus lactis]
>PYRD_AQUAE      415479668  1 -------------------------------------------   (PYRD..)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Aquifex aeolicus]
>PYRD_LACPL      2134632580  1 --------------------------------              (PYRD)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Lactobacillus plantarum]
>PYRD_AERPE      1067710699  1 -------------------------------------------   (PYRD..)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Aeropyrum pernix]
>PYDB_ENTFA      -1885456799  1  ------------------------------------------   (PYRDB..)DIHYDROOROTATE DEHYDROGENASE B, CATALYTIC SUBUNIT (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE B) (DHODEHASE B) (DHODASE B) (DHOD B).[Enterococcus faecalis]
>PYRD_ARCFU      2135421122  1 ---------------------------------------       (PYRD..)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Archaeoglobus fulgidus]
>PYRD_BACCL      -546316192  1  ------------------------------------------   (PYRD)DIHYDROOROTATE DEHYDROGENASE, CATALYTIC SUBUNIT (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Bacillus caldolyticus]
>PYRD_THEMA      256314219  1    --------------------------------------     (PYRD..)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Thermotoga maritima]
>PYRD_SULAC      761836864  1 ------------------------------------------    (PYRD)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Sulfolobus acidocaldarius]
>Q9ST36          859270587  1 -------------------------------------------   (JPR..)JPR ORF1 PROTEIN.[Pyrus pyrifolia]
>PYRD_SULSO      2003023685  1 ------------------------------------------    (PYRD..)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Sulfolobus solfataricus]
>PYRD_PASMU      1052334386  1 -----------------------------------------     (PYRD..)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Pasteurella multocida]
>Q9KXR7          -505144958  1       -------------------------------------   (PYRD)DIHYDROOROTATE DEHYDROGENASE.[Streptomyces coelicolor]
>PYRD_SCHPO      -629774491  1       -----------------------------------     (URA3..)DIHYDROOROTATE DEHYDROGENASE PRECURSOR (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE).[Schizosaccharomyces pombe]
>Q9HMK2          -845076476  1       -------------------------------------   (PYRD..)DIHYDROOROTATE DEHYDROGENASE.[Halobacterium sp.]
>AAG57285        842929516  1 -------------------------------------------   (yeiA)Putative oxidoreductase.[Escherichia coli O157:H7]
>YEIA_ECOLI      842929516  1 -------------------------------------------   (YEIA..)HYPOTHETICAL 45.1 KDA PROTEIN IN CDD-MGLC INTERGENIC REGION.[Escherichia coli]
>Q9VHP2          1780591364  1 -------------------------------------------   (DHOD..)DHOD PROTEIN.[Drosophila melanogaster]
>Q9KRZ2          98490934  1  ----------------------------------------     (VC1491)DIHYDROOROTATE DEHYDROGENASE.[Vibrio cholerae]
>PYRD_RAT        1383617261  1 -------------------------------------------   (DHODH)DIHYDROOROTATE DEHYDROGENASE PRECURSOR (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE).[Rattus norvegicus]
>Q9F1U7          269433938  1 -----------------------------------------     DIHYDROOROTATE DEHYDROGENASE.['Flavobacterium' lutescens]
>O35435          -830404798  1 -------------------------------------------   DIHYDROOROTATE DEHYDROGENASE (EC 1.3.99.11).[Mus musculus]
>O89000          -897530490  1 -------------------------------------------   (DPD)DIHYDROPYRIMIDINE DEHYDROGENASE (EC 1.3.1.2).[Rattus norvegicus]
>PYRD_HUMAN      -1000223790  1 -------------------------------------------   (DHODH)DIHYDROOROTATE DEHYDROGENASE PRECURSOR (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (FRAGMENT).[Homo sapiens]
>BAA89789        -460618259  1 -------------------------------------------   Dihydropyrimidine dehydrogenase.[Homo sapiens]
>DPYD_HUMAN      -460618259  1 -------------------------------------------   (DPYD)DIHYDROPYRIMIDINE DEHYDROGENASE [NADP+] PRECURSOR (EC 1.3.1.2) (DPD) (DIHYDROURACIL DEHYDROGENASE) (DIHYDROTHYMINE DEHYDROGENASE).[Homo sapiens]
>O01815          -847047916  1                  --------------------------   (W02D3.2)SIMILAR TO DIHYDROOROTATE DEHYDROGENASE.[Caenorhabditis elegans]
>PYRD_HELPJ      -1715226885  1                   -------------------------   (PYRD..)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Helicobacter pylori J99]
>Q9FB59          1218252557  1       --------------------------------        (PYRD)PYRD.[Corynebacterium striatum]
>PYRD_ECOLI      -592034168  1  ----------------------------------------     (PYRD..)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Escherichia coli]
>PYRD_BUCAI      -601689452  1        ----------------------------------     (PYRD..)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Buchnera aphidicola]
>Q9PAE7          751837619  1 -----------------------------------------     (XF2571)DIHYDROOROTATE DEHYDROGENASE.[Xylella fastidiosa]
>PYRD_SALTY      -451432685  1  ----------------------------------------     (PYRD)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Salmonella typhimurium]
>PYRD_HAEIN      -1559995644  1 -----------------------------------------     (PYRD..)DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1) (DIHYDROOROTATE OXIDASE) (DHODEHASE) (DHODASE) (DHOD).[Haemophilus influenzae]

Global alignment of BLAST search:

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Your query : MLNTTFANAKFANPFMNASGVHCMTIEDLEELKASQAGAYITKSSTLEKREGNPLPRYVDLELGSINSMGLPNLGFDYYLDYVLKNQKENAQEGPIFFSIAGMSAAENIAMLKKIQESDFSGITELNLSCPNVPGKPQLAYDFEATEKLLKEVFTFFTKPLGVKLPPYFDLVHFDIMAEILNQFPLTYVNSVNSIGNGLFIDPEAESVVIKPKDGFGGIGGAYIKPTALANVRAFYTRLKPEIQIIGTGGIETGQDAFEHLLCGATMLQIGTALHKEGPAIFDRIIKELEEIMNQKGYQSIADFHGKLKSL 
PYDA_LACLC : MLNTTFANAKFANPFMNASGVHCMTIEDLEELKASQAGAYITKSSTLEKREGNPLPRYVDLELGSINSMGLPNLGFDYYLDYVLKNQKENAQEGPIFFSIAGMSAAENIAMLKKIQESDFSGITELNLSCPNVPGKPQLAYDFEATEKLLKEVFTFFTKPLGVKLPPYFDLVHFDIMAEILNQFPLTYVNSVNSIGNGLFIDPEAESVVIKPKDGFGGIGGAYIKPTALANVRAFYTRLKPEIQIIGTGGIETGQDAFEHLLCGATMLQIGTALHKEGPAIFDRIIKELEEIMNQKGYQSIADFHGKLKSL  PYDA_LACLC  
Q9CFC9     : MLKTTFANAEFANPFMNASGVHCMTTEDLEELKASQAGAYITKSSTLEKREGNPLPRYVDLELGSINSMGLPNLGFDYYLDYVLKNQKEKAQEAPIFFSIAGMSAAENIAMLKKIQESNFSGITELNLSCPNVPGKPQLAYDFEATEKLLKEVFTFFTKPLGVKLPPYFDLVHFDIMAEILNQFPLTYVNSVNSIGNGLFIDSEAESVVIKPKDGFGGIGGAYIKPTALANVRAFYTRLKPEIKIIGTGGIETGQDAFEHLLCGATMLQIGTALHKEGPAIFDRIIKELEEIMDKKGYQSIADFHGKLKSL  Q9CFC9  
PYRD_YEAST :  LTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPRYISVPLGSINSMGLPNEGIDYYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNGITELNLSCPNVPGKPQVAYDFDLTKETLEKVFAFFKKPLGVKLPPYFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSIDQFRGKLNSI  PYRD_YEAST  
PYRD_STRPN :    TQIAGFEFDNCLMNAAGVACMTIEELEEVKNSAAGTFVTKTATLDFRQGNPEPRYQDVPLGSINSMGLPNNGLDYYLDYLLDLQEKESNR-TFFLSLVGMSPEETHTILKKVQESDFRGLTELNLSCPNVPGKPQIAYDFETTDRILAEVFAYFTKPLGIKLPPYFDIVYFDQAAAIFNKYPLKFVNCVNSIGNGLYI--EDESVVIRPKNGFGGIGGEYIKPTALANVHAFYQRLNPQIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKEGVSAFDRITNELKAIMVEKGYESLEDFRGKLR  PYRD_STRPN  
O76140     :           FANPFMNAAGVLCSTEEDLRCMTASSSGALVSKSCTSAPRDGNPEPRYMAFPLGSINSMGLPNLGFDFYLKYA--SDLHDYSKKPLFLSISGLSVEENVAMVRRLAPVAQGKGVLLELNLSCPNVPGKPQGAYDFEAMRTYLQQVSLAYGLPFGVKMPPYFDIAHFDTAAAVLNEFPLVKFVTCVNSVGNGLVIDAESESVVIKPKQGFGGLGGKYILPTALANVNAFYRRC-PDKLVFGCGGVYSGEDAFLHILAGASMVQVGTALQEEGPGIFTRLEDELLEIMARKGYRTLEEFRGRVKTI  O76140  
Q9NL74     :  LQVNLLNNTFANPFMNAAGVMCSTMEDLVAMTESASGSLVSKSCTPALREGNPTPRYRALPLGSINSMGLPNNGLDFYMAYAA--EQHDYGKKPLFLSMSGLSVRENAEMCKRLAAVATEKGVILELNLSCPNVPGKAQVAYDFDAMRQCFTAVSGGLPHSFGVKMPPYFDFAHFDAAAEILNEFPKVQFITCINSIGNGLVIDAETESVVIKPKQGFGGLGGHYILPTALANVNAFYRRC-PEKLIFGCGGVYTGEDAFLHVLAGASMVQVGTALQEEGPAIFERLTSELLSVMAKKGYQTLDEFRGKVKTL  Q9NL74  
P96047     :                                                                                                                                                                                  AAVFNQFPLVFVNCVNSIGNGLYI--EDESVVIKPKNGFGGIGGDYIKPTALANVHAFYQRLKPEIQIIGTGGVKSGRDAFEHILCGASMVQVGTALQKEGVAIFDRITKELKEIMAKKGYETLEDFRGKL  P96047  
Q9LAN0     :                                                                                                                                                                                                   IGNGLYI--EDESVVIRPKNGFGGIGGQYIKPTALANVHAFYQRLKPEIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKEGVVAFERITAKLKTIMEEKGYESLEDFRGKLK  Q9LAN0  
PYRD_PYRAB : MLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVELPYGLINAMGLPNPGWEAFLEEFRKEK----FDFPVIVSIFGGTPEEFAFLAEKLGE--VADAFELNLSCPHAKGYGMEIGQKPENVYE------VVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEKAGADGVSAINTVKAIA----IDIYAKRPILSNK--FGGYSGPGVKPIALRAVYDLASSL--DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIG  PYRD_PYRAB  
PYRD_PYRHO : MLEVKLFGIRFENPLILASGVVDMTPELLRRAHNEGAGGVVTKSIGKEPRKGYDNPTIVELPYGLINAMGLPNPGWEAFLNEFI----DERFDFPVIVSIFGGTPEEFAFLAEKLE--PVADAFELNLSCPHAKGYGMEIGQDPKNVYEVVKAVKDVTDKPVIAKLTPNVNDITKLGLAAERGGADGVSAINTVKAIA----IDIYAKRPILSNK--VGGYSGPGIKPIAL---RAVYDLAKVLDIPVIGIGGITSWRDAVEFLLAGASALQIGTAVYLRGFKVFKEISNGIIEYLKEEGFSSIRDIIG  PYRD_PYRHO  
PYRD_METTH : MLETSICNIELRNPTILAAGVMGSMASSLNRIYRGGAGAVVTKSFSLRPNPGYRNPTTVEVTGGVINAIGLSNPGVEAFREEL----KLVDEEVPLIASVYGASPEEFASAAASVEE--YADMIELNVSCPHAMAGCGASIGQDPELTFRVVSAVKDAVDVPISTKLTPNVTDIVEIAGSAEEAGSDALTL---INSLGPGMKIDIKTARPIL--SNAFGGMSGPAIKPVAVRCVYDVYRSV--DIPIMGVGGVRDFQDAVEFLFAGARAVQVGTAIMYDGPEVFMKICRGLEAFMMAEGFSSVDEMVG  PYRD_METTH  
Q9HL35     :  LSTSVAGIRLENPLMLASGILDENGYTMLDVMNNGAAAVVTKSIGMEERNGYSAPVIVEYGDSLINAVGLSNPGIDNFAEEIRIAKRSGK---PVIGSVFASDAESFVNLGRKMQEYGCDAV-ELNLSCPHVKGFGLEVGSDPDLVEDIVNEMKSKISVPVFAKLSPNVSDIIEIAKAAEKADAYVL--INTVKAMK----IDIRARMPVLT--NAYGGLSGPAIKPVGVRYV--YEVKKETGKDIIGVGGITTYEDAVEYIMAGASAVQIGTALYTVGKSVFRNIISQMNTFMDDEKFHSIQDMVG  Q9HL35  
PYRD_METJA : MLKTNICGIEFKNPVFLASGIMGETGSALKRIAKGGAGAVTTKSIGLNPNPGHKNPTIVEVYGGFLNAMGLPNPGVDEYLEEIEKVRDELNRMDVRIIGSIYGKDEEEFAEVAKKMER--YVDIIELNISCPHAKGYGATIGQNPDLSYDVCKAVKKAVK-------IPVFAKLTP--NVTDIIEIAQAVVDAGVDGLVAINTV-RGMAIDIRAKKPILANK--FGGLSGKAIKSIGIKVVWDLYENF--DVPIIGVGGIMSGEDAIEYMMAGASAVQIGSGVYYRGYDIFKKVCDEIISFLKEE  PYRD_METJA  
Q9CFW8     :             NPIIPASGCFGFGEEYAKYYDLNKLGSIMVKATTLHPRFGNPTPRVAETASGMLNAIGLQNPGLEVIMAEKLPWLNENFPDLPIIANVAGSEEDDYVAVCAKIGDAPNVKVIELNISCPNVKHGGQAFGTDPDVAAALVKACKAVSKVPLYVKLSPNVTDIVPIAKAVEAAGADGLTMINTL----MGVRFDLKTRKPVL--ANITGGLSGPAIKPVALKLIHQVAQVV--DIPIIGMGGVESAQDVLEMYMAGASAVAVGTANFAD-PFVCPKIIEKLPEVMDQYGIDSLENLIQEVKN  Q9CFW8  
Q9K9W1     :             NPIMPASGCFGFGKEFAGFYDLNHLGAIAIKATTVEPRFGNPTPRVAETHSGMLNAIGLQNPGLNNVIDNELARLAD--VDVPIVANIAGSTVNDYVEVAEAISRVDNVHALELNISCPNVKEGGIAFGTVPDVAAQLTQEVKRVSTVPVYVKLSPNVSDIVE---MAQAVERAGADGLSMINTL-LGMRLDLKRRTPIL--ANGTGGLSGPAIKPVAIRMI--YQVSQAVSIPIIGMGGIQSADDVLEFMLAGADAVAVGTANFTD-PYVCPTIIDELPKRMDELGIERIADIVG  Q9K9W1  
PYRD_BACSU : MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKATTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQ--FDTPIIANVAGSQVDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDV------PVYVKLSPNVANITEIALAIEEAGADGLTMINTL----IGMRLDLKTGKPILANKT--GGLSGPAVKPVAIRMV--YEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTA-NFVNPFACPEIIEQLPSVLLQYGYQSIEECIGR  PYRD_BACSU  
PYDB_LACLC :             NPIIPASGCFGFGEEYAKYYDLNKLGSIMVKATTLHPRFGNPTPRVAETASGMLNAIGLQNPGLEVIMTEKLPWLNENFPELPIIANVAGSEEADYVAVCAKIGDRANVKAIELNISCPNVKHGGQAFGTDPEVAAALVKACKAVSKVPLYVKLSPNVTDIVPIAKAVEAAGADGLTMINTL----MGVRFDLKTRQPIL--ANITGGLSGPAIKPVALKLIHQVAQDV--DIPIIGMGGVANAQVVLEMYMAGASRVAVGTANFAD-PFVCPKIIDKLPELMDQYRIESLESLIQEVK  PYDB_LACLC  
PYRD_AQUAE :  LSVELFGIRFKNPVWVASGTFGYGVEAAEIYDISKLGAVVTKGLSLKERLGNETPRIVETPCGMLNSIGLQNPGVEKFLKEIYPKIKD--VDTHFIANVFGETEEEYVEVCMALEDADKIVAYELNVSCPNVKKGGILFGHDPVILGNLVDRIKAKIKKPLLVKLSPNVTDVTEFAKVCIENGADGLVLINTL--MGMKINIWKRKPDLATKT----GGLSGPAILPIAVRMIYQVYEKFGDRIPIIGVGGITTWEDAMEHVMAGASAVQVGTANFYEPLA----PLKVIEGIENFMKSQNIKDF  PYRD_AQUAE  
PYRD_LACPL :  LTVNLAGVTFKNPVMPASGTAAYGQQMAQQLDLSALGGLVIKSTTAEPKAGNPRPTTAETTAGWLNAIGLKNPGIDNVLADKLPWLATHYPDLPIIGSVAGASFDEYVAVARKMASAPNVKLLEINISCPNVDHGGLAFGTDPATVTALTKAIVAAVDKPVFMKLTPNVTDIVPIALAAEAGGAAGLTMINTLTGMG----IDLATRQPIL--AHGTGGLSGKAIHPLAV  PYRD_LACPL  
PYRD_AERPE :  LSISIAGLRLQRPVGNASGILGWEPREARLVEEGGGGFFVAKSVTYQPRKGYPQPHLYPVAGGIVNAVGLANPGFREASKMLAQTVEEASI--PVIASIAGGAPGEWVEMASTLEEAGVSAV-ELNLSCPHFAGGGLELGQDPAAVASVVSAVASTLRIPVIAKLGYSDRLVDAASKALEAGARGLTLINSMRA----MKIDVYAKKPVLGNR--VGGLSGKPIHPIAVRAVYEVYGETR--ADIFAAGGVESWEDAVEFYLAGAKAVQVGAAFITIGPHVLRSIVEGVRRYLWVEGFRSLQDIVG  PYRD_AERPE  
PYDB_ENTFA :             NPIIPASGCFGFGEEYANYYDLDQLGSIMIKATTPQARYGNPTPRVAETPSGMLNAIGLQNPGLDVVMQEKLP-KLEKYPNLPIIANVAGACEEDYVAVCAKIGQAPNVKAIELNISCPNVKHGGIAFGTDPEVAFQLTQAVKKVASVPIYVKLSPNVTDIVPIAQAIEAGGADGFSMINTL----LGMRIDLKTRKPILANQT--GGLSGPAIKPVAIRLIRQVASVSQLP----IIGMGGVQTVDDVLEMFMAGASAVGVGTANFTD-PYICPKLIDGLPKRMEELGIESL  PYDB_ENTFA  
PYRD_ARCFU :  LETEIGGLRMKNPLMLASGIMGSKVHSLN-LIARDAGAVVTKSVGVEEREGYRNPTVVNWKCGLINAVGLASPAAKDFAEEL----KDYTNEAPLLISLYGHSVEEFSDLVDTFDSALPYLHGYELNLSCPHVKGAGLDIGMDLELSAAIVEELKGKTKNPVFAKLSAMHDYLK---LAKVLEDAGVDGITISNTL-RGMKIDIMSGKPVLSNLS--GGVSGPAIKPIALKCVYDLYKEIE--VPIVGCGGITSFEDVLEFIMAGARAVQIGSAVY  PYRD_ARCFU  
PYRD_BACCL :             NPIMPASGCFGFGREYARFYDLSVLGAIMIKATTKEPRFGNPTPRVAETPGGMLNAIGLQNPGLDKVLEEELPWLEQ--FDVPIIANIAGSTVEEYVEVAEAISKAPNVHALELNISCPNVK-KGGIAFGTVPDVAAELTRLVKEVAAVPVYVNVSP--NVTDIVAMAKAIEQAGADGLTMINTL-VGMRIDVKTGRPIL--ANGTGGLSGPAVKPIAIRMI--YEVSQAVSIPIIGMGGIQTAEDVLEFFYAGASAVAVGTANFVD-PFVCPTIIADLPALLDDLGIGHISECIGR  PYRD_BACCL  
PYRD_THEMA :                           EYLKLMDHRYVGGVLLKTVTLHPKEGNPTPRMADSDFYVINRIGLENPGIHAFV--------ENIPELPVPMIASLGGDSFEEYLEVARVFKKVADRFYAVEFNFSCPNVKEGGLSIVKNAEEWKKLLNTLRKELPDSFLIAKVGV------EGIFVEDAAEFVMKTGWDGITLVNTV-RGLHF--EKDTMIL------GGLSGPVLKPIALRAVYEVKKRF-PELFVIASGGVYSVKDAEEFLKVGADVIGVGSALFKD-PGVVEEIGKYLLEV  PYRD_THEMA  
PYRD_SULAC :       AGVNFEDPIVIASGIVPPTKEYMQNVCEKYEPSAITSKTLTYSPLEPHRSPTFVKISDNCYLNAIGLGNPGIQILRDLGEIKCK-------LIISIGGSNVNEYIDAVSKI--NDIPVMIELNVSSPNRRGFGESNLTY----VEEIVKNVKSIVKKPVFVKLGPWDNIVEIAGRALSAGADGLTLINTL----KGMLIDVEDFKPIL--SYGTGGISGKCIHALAVRVIHDVFKEYEP--EIIGVGGVFDWRDAIELISVGAKLVGLGTVLVEKGFDVIREIREGIGTYLEEKG  PYRD_SULAC  
Q9ST36     :  LSVTVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGAVIAKTVSLEADKVKNVTPRYARLRVDGNGSAKGQIIGWENIELISDRPLDIMLKEFKQLKQEYPDRILIASIMEEYNKAGWEELIDRVEQTGVDAL-EINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVPVWAKMTP--NITDITQPARVALSSGCEGVSAINTIMSVMGIN----LTTLRPEPCVEGYSTPGGYSAKAVHPIALAKVMNIAKLMKSEFGDTDYSLSGIGGVESGGDAAEFILLGANTVQVCTGVMMHGYGVVKKLCSELQDFMKQHNFSSIEDFRG  Q9ST36  
PYRD_SULSO :     TIKNITLNDPLIIASGIIPDVPNYVETICEKYKPSAITTKTVTLNPLEPHKPPTVIKLHDGIYMNAIGLGNPG--------AKAINEIGVLCPLIVSVGGSSINEIKEVVEVVQSK--AKIIEINVSSPNRKGYG------ESLSKLIGDIIESVKSVTKLPVFVKLGPWDNVIELAGKALEKGADGLTLINTIK----GLIIDVETFKPILYY--GTGGVSGRCLYPIALRIIKDVYEEY--GVDIIGVGGVYDWTDVIGMLAAGAKLVGLGTVLIEKGFSVIEEIRKGLQSYLLEKG  PYRD_SULSO  
PYRD_PASMU :     TIMGLHFKNPIGLAAGAD-KNGEAIEGFAAMGFGFIEVGTVTPLAQEGNPKPRQFRLPEAEGIINRNGFNNYG----IDYLIENVKHANYDGILGINIGKNTFTSVENGKADYLICLNKAYHYADYITI---NISSPNSPGLRQLQYG-EALEDLLQGVKARQKDLAEQYQKYVPIAVKIAP--DLTEGEVVQIADTLQRHKMDAVIATNTT-----ISRDTVSG-LQNAEQQGGLSGKPLQQKSTEIIARLHQELKGQIPIIGSGGIDSVANAQEKIKAGAELLQLYSGLIYHGPHLIKQLVQQIK  PYRD_PASMU  
Q9KXR7     :                                              TGEPQPGNPKKRLFRLVADRALINRMGFNN-------DGSLAVAARLASRTPVFRTVVGVNIGKTKVVPEEEAVGDYVKSAERLAPHADYLVVNVSSPNTPGLRNLQAT-EALRPLLSAVREAADRAVTARRVPLLVKIAPDLADEDVDAVADLAVELGLDGIIATNTTIAREGLGLTSSPALVGET-------GGLSGAPLKARSLEVLRRLYARVGDRITLVGVGGVETAEDAWERILAGATLVQGYSAFIYEGPFWGRAMHKGLAARLRQSPYATLADAVG  Q9KXR7  
PYRD_SCHPO :                                            SVTPKPQPGNPKPRYFRLKPDLSVINRYGFNSIGHDAILAKIQKRVRKYIAKTSPQLLKQFDANPASCTDPAVLGVPRSLIPNKFLGINLGKNKNGNEIEDYVEGVRTFGNFADILVINVSSPNTPGLRNLQKK-SALSTLLTAVVSERNKLNSPHPPVLVKIAPDLNEEELTDIADVLKKCKIDGV----IVGNTTVQRPKTLKSTSHVEET-GGLSGPPLKPIALNTLRTLRKHLSSDIPIIGCGGISSGKDAIEYARAGATMVQVYTALGYDGPVIAHKIKQEI  PYRD_SCHPO  
Q9HMK2     :                                              TAERQPGNDRPRLFRLPDDNALVNRMGFNNEGAD---TVGARLDAEPLPDVPVGVNI-GKSKTTPLADAPDDYTYTFSRVGDAVDYVVVNVSSPNTPGLRELQ-GRDQLAAILEALQDAGASPLLVKLSP--DL-HQDAVADAVELANDLGLDGIVATNTTTER----PESLS---HPHAGEQGGLSGAPIRERATEQVR--FVAERTDQPVVGVGGVATAEDAYEKIRAGASVVQLYTALVYEGPWVAKRINEGLVSLLERDGFDSVEDAVG  Q9HMK2  
AAG57285   :  LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFK--TIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITN-IDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG  AAG57285  
YEIA_ECOLI :  LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFK--TIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITN-IDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG  YEIA_ECOLI  
Q9VHP2     :  LHTSFFGRMLSNPIGIAAGFD-KNAEAVDGLQDLGFGFIEVGTVTPAAQEGNPKPRVFRLTEDKAIINRYGFNSDGHQAVLQRLRLLRKKEN------FNGVVGVNLGRNKTTMSPIADYVQGVRVFGPVADYLVINVSSPNTKGLRDMQSK-EKLRELLEQVNDTKSSLDKNKNVPILLKLSPDLSL---DDMKDIV-----WVIKRKKSRVDGLIVSNTTVSRENIEKNKLAEETGGLSGPPLKARSTEMIAQMYQLTDGKIPIIGVGGVASGYDAYEKIEAGASYVQIYTALVYEGPALVEDIKAELSALITRLGHTNVADVVG  Q9VHP2  
Q9KRZ2     :           FKNPVGLAAGLD-KNGECIEAFGAMGFGFVEVGTVTPRPQAGNDKPRLFRLVHAEGIINRMGFNNLG----VDHLVENVKRAKYDGIIGINIGKNKDTPIEKGAEDYLICMDKVYP--YAGYIAVNISSPNTPGLRSLQYG-EALDELLAALKTRQAELAAKHDKYVPLALKIAP--DLSDDEIQ-QICQSLLKNKIDSV--IATNTTLD---RSLVEGMKFANEAGGLSGRPLQNRSTEVIKCLYKELGEEIPIIGVGGIDSYISAKEKLLAGAKLVQVYSGFIYQGPGLVADIVKNL  Q9KRZ2  
PYRD_RAT   : MLEVKVLGHKFRNPVGIAAGFD-KNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQ-----LTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRH-LLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKED--------IASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIG  PYRD_RAT  
Q9F1U7     :  LPTRAFGLEFPNPVGLAAGLD-KNGEHIDALFALGFGYVEIGTVTPRPQAGNPQPRLFRVPEHLGVINRMGFNNAGVDALVANVRAARRDRG--------ILGINIGKNKDTPNELAHTDYLTCLEKVYALADYITVNISSPNTAGLRELQEEQALRELVSRLREGQETLAARHGKRVPMLVKVAPDLSDADVDAAARVLAELQVDGVIATNTTIARVGMENHPLASEA--------GGLSGAPVMARSTAVLRRLRTRLPESIPLIGVGGICSGADAAAKMSAGATMVQLYSGLVYRGPALVGECVESI  Q9F1U7  
O35435     : MLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGF---GFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLAD-----YLVVNVSSPNTAGLRSLQGKTE-LRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDI----ASVARELGIDGLII---TNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIG  O35435  
O89000     :  ISVEMAGLRFPNPFGLASATPATSTPMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIR----GTTSGPLYGPGQSSFLNIELISEKTAAYWCHSVTELKADFPDNILIASIMCSYNKNDWMELSKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQSVRVPFFAKLTPNVTDIVSIARAAKEGGADGVTATNTVSGL-MGLKADGSPWPSVGSGKRTTYGGVSGTTIRPIALRAVTAI-ARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELSDWDGQ  O89000  
PYRD_HUMAN : MLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGF---GFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVL-GPLADYLVVNVSSPNTAGLRSLQGKAEL-RRLLTKVLQERDGLRRVHRPA----VLVKIAPDLTSQDKEDIASVVKELGIDGLIV---TNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIG  PYRD_HUMAN  
BAA89789   :  ISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTE-LKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGL-MGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSI-ARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQ  BAA89789  
DPYD_HUMAN :  ISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTE-LKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGL-MGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSI-ARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQ  DPYD_HUMAN  
O01815     :                                                                                                                              LNVSSPNTPGLRSMQKKSDL-EKLLAYVHQALEMHKLEKQPQVFLKIAPDLIESELKDIAQVVTNKKFAI-DGIIV---SNTTIARPDYLRSENKTETGGLSGAPVREISTECVRKIYKLTNGQIPIIGCGGVFSGADAYEKIRAGASLVQLYSAFVYEGFPVIGKIKRELVELLRKDGFSHVSEAIG  O01815  
PYRD_HELPJ :                                                                                                                               NLSSPNTPNLRDLQNKVFVNELFCMAKEMTH---KPLFLKIAPDLEI---DSMLEVVNSAIEAGANGI--IATNTTID---KSLVFAPKE-MGGLSGKCLTKKSREIFKELAKAFFNKSVLVSVGGISDAKEAYERIKMGASLLQIYSAFIYKGPNLCQNILKDLVKLLQKDGFLSVKEAIG  PYRD_HELPJ  
Q9FB59     :                                              TPKSQPGNPTPRLFRLPEDKAILNRMGFNNKGALVVAD----NLRARRSRDVVGINIGKNKTSEDAVADYRATSTLLGQLADYLVVNVSSPNTPG----LRDLQAVEELRPILEVVKKSTTTPVLVKIAPDLSDEDIDAVADLAVELELAGIVATNTTISRSGLKTPASKV---EKMGAGGISGAPLENRSLEVLKRLHERVGDKLVLVSVGGISTPEQAWERITAGASLLQ  Q9FB59  
PYRD_ECOLI :           FKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAE-GLINRMGFNNLG----VDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYA--YAGYIAINISSPNTPGLRTLQYG-EALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQG------MKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI  PYRD_ECOLI  
PYRD_BUCAI :                                                    GNPKPRMFRIVSME-GIINRMGFNNLG----IDNLIRNIKKSNFKGIIGVNIGKNKSTSLENSVDDYLICIEKIY--CYAGYIAINISSPNTTNLRNLQYGI-LFKKLLYKIKKKQKELHKKYLKYVPIAIKISPDLSIKELVDISKQLIRYKIDAVIATNTTLD------HSSLFGLKNSSEQGGLSGLPLQKKSTNTISILSKSLQKKIPIIGVGGINSINSAKEKIESGATLIQIYSGLVYHGPKLIKKIINHI  PYRD_BUCAI  
Q9PAE7     :  LPTTAFGLNFPNPVGLAAGLD-KNGTHIDALFALGFGFIEIGTTTPRPQPGNPKPRLFRLTQQQAVINRMGFNNLGVDALVRNVAGARQRN---GPL-----GINIGKNKDTPNEQASNDYRYCLERVYALADYVTINLSSPNTAGLRALQEE-QTLRRLIGELREAQETLAAKHGRHVPMLIKMAPDLSDSDIDAAARVLNEMSVDGVIATNTTVTRPLLRQHRLASET-------GGLSGAPLLGQSTLVLRRLRTHLPETIALIGVGGICCGADAVAKMAAGANLVQCYTGLIFKGPQLVGECVEAI  Q9PAE7  
PYRD_SALTY :           FKNPLGLAAGLD-KDGECIDALGAMGFGSLEIGTVTPRPQPGNDKPRLFRLVDAE-GLINRMGFNNLGVDNLVENVKKAH---------FDGILGINIGKNKDTPVENGKDDYLICMEKVYA--YAGYIAINISSPNTPGLRTLQYG-DALDDLLTAIKNKQNDLQAIHHKYVPVAVKIAP--DLCEEELIQVADSLLRHNIDGVIATNTTLDRSLVQG------MKNCQQTGGLSGRPLQLKSTEIIRRLSQELKGQLPIIGVGGIDSVIAAREKIAAGATLVQIYSGFIFKGPPLIKEIVTHI  PYRD_SALTY  
PYRD_HAEIN :     TVMGVNFPNPIGLAAGAD-KNGDAIDGFGALGFGFLELGTVTPVAQDGNAKPRQFRLIEAEGIINRNGFNNNG----IDYLIENVKNARYKGVIGINIGKNKFTSLEQGKDDYIFCLNKAYNYAGYITVNISSPNTPDLRQLQYGDYFDDLLRSIKDRQAILANQYNKYVPIAVKIAP--DLTESELVQIADTLVRHKMDGVIATNT-------TISRDTVTGMKNAEQQGGLSGKPLQHKSTEIIKRLHQELKGQIPIIGSGGIDGLQNAQEKIEAGAELLQVYSGLIYHGPKLVKELVKNIK  PYRD_HAEIN