Inosine Monophosphate Dehydrogenase

PDB code: 1ak5
E.C. Number: 1.1.1.205
Oligomeric unit: tetramer
No of residues: 503
Topology diagram:


PDB
SCOP
CATH
IBM-JENA
MMDB
FSSP
Relibase


Ramachandran Phi Psi values:

Global summary of BLAST search:

QUERY= Submission, 503 bases, AB870BFB checksum. 

                        |==============================================|503
>IMDH_TRIFO       2531  1 ---------------------------------------------- (IMPDH)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Tritrichomonas foetus]
>Q9KTW3          1902738329  1 ---------------------------------------------  (VC0767)INOSINE-5`-MONOPHOSPHATE DEHYDROGENASE.[Vibrio cholerae]
>Q9X168          318893625  1 ---------------------------------------------  (TM1347)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE.[Thermotoga maritima]
>Q9L6B7          -1700294624  1 ---------------------------------------------  (GUAB..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (GUAB).[Pasteurella multocida]
>IMDH_AQUAE      109077765  1 ---------------------------------------------  (GUAB..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Aquifex aeolicus]
>Q9KGN8          209220968  1 ---------------------------------------------  (GUAB)INOSITOL-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205).[Bacillus halodurans]
>IMDH_ECOLI      1727500278  1 ---------------------------------------------  (GUAB..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Escherichia coli]
>IMDH_HAEIN      629666383  1 ---------------------------------------------  (GUAB..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Haemophilus influenzae]
>IMDH_CHLVI      1502048099  1 ---------------------------------------------  (GUAB)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Chlorobium vibrioforme]
>Q9HXM5          -206157747  1 ---------------------------------------------  (GUAB..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE.[Pseudomonas aeruginosa]
>IMDH_ACICA      288048701  1 ---------------------------------------------  (GUAB)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Acinetobacter calcoaceticus]
>Q9RHG1          209220931  1 --------------------------------------------   (IMPDH)IMPDH.[Bacillus cereus]
>IMD1_HUMAN      -2139488640  1 --------------------------------------------   (IMPDH1..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1 (EC 1.1.1.205) (IMP DEHYDROGENASE 1) (IMPDH-I) (IMPD 1).[Homo sapiens]
>Q9JZB5          2069487030  1 ---------------------------------------------  (NMB1201)IMP DEHYDROGENASE.[Neisseria meningitidis]
>Q9JUD0          2071466740  1 ---------------------------------------------  (GUAB..)PUTATIVE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205).[Neisseria meningitidis]
>IMDH_BACSU      1583711113  1 --------------------------------------------   (GUAB..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD) (SUPEROXIDE-INDUCIBLE PROTEIN 12) (SOI12).[Bacillus subtilis]
>Q9RHG9          209220921  1 --------------------------------------------   (IMPDH)IMP DEHYDROGENASE.[Bacillus cereus]
>Q9L0I7          1906613846  1 --------------------------------------------   (SCD63.02)INOSINE 5' MONOPHOSPHATE DEHYDROGENASE.[Streptomyces coelicolor]
>Q9PAR5          -612116060  1 ---------------------------------------------  (XF2430)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE.[Xylella fastidiosa]
>IMDH_MYCTU      -846837703  1 ---------------------------------------------- (GUAB..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Mycobacterium tuberculosis]
>IMDH_MYCLE      -1945334311  1 ---------------------------------------------- (GUAB..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Mycobacterium leprae]
>Q9PNN3          318750953  1 ---------------------------------------------  (GUAB..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205).[Campylobacter jejuni]
>O96387          -1897234062  1   ----------------------------------------     INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE.[Plasmodium falciparum]
>IMDH_STRPY      -1096952464  1 ---------------------------------------------  (GUAB)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Streptococcus pyogenes]
>IMD1_MOUSE      -2139488660  1 --------------------------------------------   (IMPDH1)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1 (EC 1.1.1.205) (IMP DEHYDROGENASE 1) (IMPDH-I) (IMPD 1).[Mus musculus]
>IMDH_METJA      295699085  1 ---------------------------------------------  (GUAB..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Methanococcus jannaschii]
>IMDH_DROME      2017335046  1 -----------------------------------------      (RAS..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD) (RASPBERRY PROTEIN).[Drosophila melanogaster]
>Q9CIY6          -1096952458  1 ---------------------------------------------  (GUAB)IMP DEHYDROGENASE (EC 1.1.1.205).[Lactococcus lactis]
>IMDH_HELPJ      1587502748  1 ---------------------------------------------  (GUAB..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Helicobacter pylori J99]
>IMDH_HELPY      1587502748  1 ---------------------------------------------  (GUAB..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Helicobacter pylori]
>Q9P8J2          -530494935  1 --------------------------------------------   (IMH3)PUTATIVE INOSINE 5-MONOPHOSPHATE DEHYDROGENASE.[Candida albicans]
>Q9RT87          -477378248  1 ---------------------------------------------  (DR1878)INOSINE-5`-MONOPHOSPHATE DEHYDROGENASE.[Deinococcus radiodurans]
>IMH3_CANAL      -530494938  1 --------------------------------------------   (IMH3)PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Candida albicans]
>O14344          1756004686  1 -------------------------------------          (SPBC2F12.14C)PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Schizosaccharomyces pombe]
>Q9RHZ0          -1938975771  1 --------------------------------------------   (GUAB)IMP DEHYDROGENASE.[Corynebacterium ammoniagenes]
>IMD2_HUMAN      876400444  1 --------------------------------------------   (IMPDH2..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (EC 1.1.1.205) (IMP DEHYDROGENASE 2) (IMPDH-II) (IMPD 2).[Homo sapiens]
>IMD2_MOUSE      1937173473  1 --------------------------------------------   (IMPDH2..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (EC 1.1.1.205) (IMP DEHYDROGENASE 2) (IMPDH-II) (IMPD 2).[Mus musculus]
>IMH2_YEAST      401009659  1 --------------------------------------------   (YLR432W..)PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Saccharomyces cerevisiae]
>IMD2_MESAU      1938792470  1 --------------------------------------------   (IMPDH2..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (EC 1.1.1.205) (IMP DEHYDROGENASE 2) (IMPDH-II) (IMPD 2).[Mesocricetus auratus]
>Q9UVL0          -648229097  1 --------------------------------------         INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE.[Pneumocystis carinii]
>Q9GZH3          1480531187  1 --------------------------------------------   (T22D1.3)T22D1.3 PROTEIN.[Caenorhabditis elegans]
>Q9KH33          629087482  1 ---------------------------------------------  (GUAB)GUAB.[Rhizobium tropici]
>IMH3_YEAST      -1484128687  1 --------------------------------------------   (YML056C..)PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Saccharomyces cerevisiae]
>IMH1_YEAST      -81603763  1 --------------------------------------------   (PUR5..)PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Saccharomyces cerevisiae]
>IMDH_LEIDO      415756758  1 ----------------------------------------       INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Leishmania donovani]
>IMDH_PYRFU      -333840826  1 ---------------------------------------------  (GUAB)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Pyrococcus furiosus]
>Q9UY49          733869602  1 ---------------------------------------------  (PAB1250)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Pyrococcus abyssi]
>Q9HQU4          636914057  1 ---------------------------------------------- (GUAB..)INOSINE MONOPHOSPHATE DEHYDROGENASE.[Halobacterium sp.]
>IMDH_TRYBB      -1614907162  1 ----------------------------------------       INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Trypanosoma brucei brucei]
>IMDH_PYRHO      733869600  1 ---------------------------------------------  (GUAB..)INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).[Pyrococcus horikoshii]

Global alignment of BLAST search:

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Your query : MAKYYNEPCHTFNEYLLIPGLSTVDCIPSNVNLSTPLVKFQKGQQSEINLKIPLVSAIMQSVSGEKMAIALAREGGISFIFGSQSIESQAAMVHAVKNFKAGFVVSDSNVKPDQTFADVLAISQRTTHNTVAVTDDGTPHGVLLGLVTQRDYPIDLTQTETKVSDMMTPFSKLVTAHQDTKLSEANKIIWEKKLNALPIIDDDQHLRYIVFRKDYDRSQVCHNELVDSQKRYLVGAGINTRDFRERVPALVEAGADVLCIDSSDGFSEWQKITIGWIREKYGDKVKVGAGNIVDGEGFRYLADAGADFIKIGIGGGSICITREQKGIGRGQATAVIDVVAERNKYFEETGIYIPVCSDGGIVYDYHMTLALAMGADFIMLGRYFARFEESPTRKVTINGSVMKEYWGEGSSRARNWQRYDLGGKQKLSFEEGVDSYVPYAGKLKDNVEASLNKVKSTMCNCGALTIPQLQSKAKITLVSSVSIVEGGAHDVIVKDRINDYHPK 
IMDH_TRIFO : MAKYYNEPCHTFNEYLLIPGLSTVDCIPSNVNLSTPLVKFQKGQQSEINLKIPLVSAIMQSVSGEKMAIALAREGGISFIFGSQSIESQAAMVHAVKNFKAGFVVSDSNVKPDQTFADVLAISQRTTHNTVAVTDDGTPHGVLLGLVTQRDYPIDLTQTETKVSDMMTPFSKLVTAHQDTKLSEANKIIWEKKLNALPIIDDDQHLRYIVFRKDYDRSQVCHNELVDSQKRYLVGAGINTRDFRERVPALVEAGADVLCIDSSDGFSEWQKITIGWIREKYGDKVKVGAGNIVDGEGFRYLADAGADFIKIGIGGGSICITREQKGIGRGQATAVIDVVAERNKYFEETGIYIPVCSDGGIVYDYHMTLALAMGADFIMLGRYFARFEESPTRKVTINGSVMKEYWGEGSSRARNWQRYDLGGKQKLSFEEGVDSYVPYAGKLKDNVEASLNKVKSTMCNCGALTIPQLQSKAKITLVSSVSIVEGGAHDVIVKDRINDYHPK  IMDH_TRIFO  
Q9KTW3     :           TFDDVLLVPAHSTV--LPNTADLRTRLTK-------NIALNIPMVSASMDTVTEARLAIALAQEGGIGFIHKNMSIEQQAAQVHQVKIFEAGVVTHPVTVRPEQTIADVMEL---THYHGFAGFPVVTENNELVGIITGRDVRFVTDLTKS---VAAVMTPKERLATVKEGATGAEVQEKMHKARVEKILVVNDEFQLKGMITAKDFHKAESKPNACKDEQGRLRVGAAVGAAPGNEERVKALVEAGVDVLLIDSSHGHSEGVLQRIRETRAAY-PHLEIIGGNVATAEGARALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQITAIADAAGVANEY------GIPVIADGGIRFSGDISKAIAAGASCVMVGSMFAGTEEAPGEVILYQGRSYKAYRGMGSLGAMSKGSSDRYFQTDNAADKLVPEGIEGRIAYKGHLKEIIHQQMGGLRSCMGLTGSATVEDLRTKAQFVRISGAGMKESHVHDVQITKEAPNY  Q9KTW3  
Q9X168     :           TFDDVLLVPQYSEV--LPKDVKIDTRLTR-------QIRINIPLVSAAMDTVTEAALAKALAREGGIGIIHKNLTPDEQARQVSIVKKTENGIIYDPITVTPDMTVKEAIDLMAEYKIGGLPVVDE---EGRLVGLLTNRDVRFEKNLSK-KIKDLMTPREKLIVAPPDISLEKAKEILHQHRIEKLPLVSKDNKLVGLITIKDIMSVIEHPNAARDEKGRLLVGAAVGTSPETMERVEKLVKAGVDVIVIDTAHGHSRRVIETLEMIKADYPD-LPVVAGNVATPEGTEALIKAGADAVKVGVGPGSICTTRVVAGVGVPQLTAVMECSEVARKY------DVPIIADGGIRYSGDIVKALAAGAESVMVGSIFAGTEEAPGETILYQGRKYKAYRGMGSLGAMRSGSADRYGQEGENKF-VPEGIEGMVPYKGTVKDVVHQLVGGLRSGMGYIGARTIKELQEKAVFVKITPAGVKESHPHDIIITKESPNY  Q9X168  
Q9L6B7     :           TFDDVLLVPAHSTV--LPNTADLSTQLTK-------TIRLNIPMLSAAMDTVTETKLAISLAQEGGIGFIHKNMSIERQAERVRKVKKFESGIVSDPVTVSPTLSLAELSELVKKNGFASFPVVDD---EKNLVGIITGRDTRFVTDLNKT---VADFMTPKARLVTVKRNASRDEIFGLMHTHRVEKVLVVSDDFKLKGMITLKDYQKSEQKPQACKDEFGRLRVGAAVGAGPGN---EERIDALVKAGVDVLLIDSSHGHSEGVLQRVRETRAKYPD-LPIVAGNVATAEGAIALADAGASAVKVGIGPGSICTTRIVTGVGVPQITAIADAA----EALKDRG--IPVIADGGIRFSGDISKAIAAGASCVMVGSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGRIPYKGFLKEIIHQQMGGLRSCMGLTGCATIDELRTKAQFVRISGAGIQESHVHDVTITKEAPNY  Q9L6B7  
IMDH_AQUAE :           TFDDVLLVPQYSEV--LPHEVDVSTYLTK-------RIKLNIPIVSAAMDTVTEARLAIALAREGGIGIIHRNLPIKKQAEEVEKVKKSESGMIINPVTVKPDTRVKEALDIMAKYKISGVPVVDE---ERKLIGILTNRDLRFIKPEDYSKPVSEFMTK-ENLITAPEGITLDEAEEIFRKYKIEKLPIVDKEGKIKGLITIKDIVKRKKYPNACKDELGRLRVGAAVGTGEETLDRVAALVEAGVDVIVVDTAHGHSKRVLETVEKIKANF-PEVDVIAGNVATAEGTKALIEAGADAVKVGVGPGSICTTRIVAGVGVPQLTAIMEAASAAREY------DIPIIADGGIRYSGDIVKALAAGASAVMLGNLLAGTEEAPGETIYYQGRAYKVYRGMGSLGAMSSRLSSDRYGQEKMEKFVPEGIEGRVPYKGKLADVVYQLVGGLRSGMGYVGARNIKELQEKAKFVRITWAGYRESHVHDVQITREAPNY  IMDH_AQUAE  
Q9KGN8     :           TFDDVLLVPAKSEV--LPRDVSVKTKLTE-------TLQLNIPIISAGMDTVTEAKMAIAIAREGGLGIIHKNMSVEEQAEQVDRVKRSESGVITNPFFLTPDRQVFDAEHLMGKYRISGVPIVDEDQK---LVGILTNRDLRF-IEDYSTLIDDVMTK-ENLVTAPVGTTLKEAEEILQKHKIEKLPLVDESGTLKGLITIKDIEKVIEFPNSAKDSQGRLIVGAAVGVSADTDVRVAALVEAGVDVIVIDTAHGHSKGVLEKVKAIREQYPD-LTIIAGNVATAEATRDLIEAGANVVKVGIGPGSICTTRIVAGIGVPQITAVYDCANEARKH------GVPIIADGGIKYSGDIVKALAAGGHAVMLGSLLAGVSESPGEREIFQGRQFKVYRGMGSLGAMEKGSKDRYFQENNQKL-VPEGIEGRIPYKGPLHDTIHQLVGGIRAGMGYCGTKTIDELRENTQFIRITGAGLRESHPHDVQITKEAPNY  Q9KGN8  
IMDH_ECOLI :           TFDDVLLVPAHSTV--LPNTADLSTQLTK-------TIRLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTER---NGFAGYPVVTEENELVGIITGRDVRF-VTDLNQPVSVYMTPKERLVTVREGEAREVVLAKMHEKRVEKALVVDDEFHLIGMITVKDFQKAERKPNACKDEQGRLRVGAAVGAGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIG-GNVATAAGARALAEAGCSAVKVGIGPGSICTTRIVTGVGVPQITAVADAV----EALEGTG--IPVIADGGIRFSGDIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAGIQESHVHDVTITKESPNY  IMDH_ECOLI  
IMDH_HAEIN :           TFDDVLLVPAHSTV--LPNTANLSTQLTK-------EIRLNIPMLSAAMDTVTETKLAISLAQEGGIGFIHKNMTIERQADRVRKVKKFESGIVSEPVTVLPNLTLAELAEMVKKNGFAGYPVVDG---ENNLIGIITGRDTRFVKDLSKT---VSQVMTKKEDLVTVKEGASREEILELMHQHRVEKVLVVNDSFKLKGMITVKDFQKAEQKPNACKDEFGRLRVGAAVGAGAGNEERIDALVKAGVDVLLIDSSHGHSEGVLQRVRETRAKY-PNLPIVAGNVATAEGAIALADAGASAVKVGIGPGSICTTRIVTGVGVPQITAIADAAAA----LKDRG--IPVIADGGIRFSGDIAKAIAAGASCVMVGSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMAKGSSDRYFQSDNAADKLVPEGIEGRIPYKGYLKEIIHQQMGGLRSCMGLTGCATIDELRTKAEFVRISGAGIKESHVHDVAITKEAPNY  IMDH_HAEIN  
IMDH_CHLVI :   KYFNKPPMDKILYDALTFDDVLLVPAYSNV--LPKET-----VVKSRVTRNIEVNL--PLVSAAMDTVTEAELAIALARAGGIGIIHKNLSIDVQARHVAKVKRFESGIIRNPITLFEDATIQEAIDLMLRHSISGIPVVERPTPEGCLLLKGIVTNRDLRM-TTSSNEKITTIIT--TDLITAQEDIDLLAAEEILMQNKIEKLLVIDEEGYLKGLITFKDIQKRKQCPDACKDMHGRLRVGAAVGIRSNTITRVDALVEAGVDVVAVDTAHGHSQAVLDMVATIKEKY-PELEVIAGNVATPEAVRDLVKAGADAVKVGIGPGSICTTRVVAGVGMPQLTAIMNCAKEAAK------TDTPIIADGGIKYSGDISKALAAGADTVMMGSIFAGTDESPGETILYEGRRFKAYRGMGSLGAMSEPEGSSDRYFQDASAETKKYVPEGIEGRIPQR-PLDEVVYQLIGGLKSSMGYCGVKNIEELKKNTRFVRITSAGLRESHPHDVMITREAPNY  IMDH_CHLVI  
Q9HXM5     :           TFDDVLLIPGYSEV--LPKDVSLKTRLTR-------GIELNIPLVSAAMDTVTEARLAIAMAQEGGIGIIHKNMGIEQQAAEVRKVKKHETAIVRDPVTVTPSTKIIELLQMAREYGFSGFPVVEQGE----LVGIVTGRDLRVKPNAGDT-VAAIMTPKDKLVTAREGTPLEEMKAKLYENRIEKMLVVDENFYLRGLVTFRDIEKAKTYPLASKDEQGRLRVGAAVGTGADTGERVAALVAAGVDVVVVDTAHGHSKGVIERVRWVKQTFPD-VQVIGGNIATAEAAKALAEAGADAVKVGIGPGSICTTRIVAGVGVPQISAIANVAAA----LEGTG--VPLIADGGIRFSGDLAKAMVAGAYCVMMGSMFAGTEEAPGEIELFQGRSYKSYRGMGSLGAMSGSQGSSDRYFQDASAGAEKLVPEGIEGRVPYKGALSAIVHQLMGGLRAAMGYTGSADIQQMRTQPQFVRITGAGMAESHVHDVQITKEAPNY  Q9HXM5  
IMDH_ACICA :           TFDDVLLLPAYSTV--LPKDVSLKTRLTR-------GIYLNIPLVSAAMDTVTESRMAIAMAQNGGIGILHKNMDIAAQAAEVRRVKKFEAGMVKDPITVSPETTVRELIAITSANNISGVPVVKDSK----VVGIVTGRDTRFE-TNLEQPVSNIMTGQDRLVTVREGESKENIQALLQKHRIEKVLVVGESNELKGLITVTDFRKAESYPNSCKDDLGRLRVGAAVGTGADTPSRVEALVEAGVDVIVVDTAHGHSAGVIERVRWVKQNF-PQVQVIGGNIATGDAALALLDAGADAVKVGIGPGSICTTRIVAGIGMPQISA-IDSVASALK------DQIPLIADGGIPFSGDMAKAIGAGASTIMVGSLLAGTEEAPGEVEFFQGRYYKAYRGMGSLGAMAGRTGSADRYFQDSKAGAEKL-VPEGIEGRVPYKGPMGNIVHQMMGGLRSSMGYTGSAVIEDLRQNAKFVKITSAGMSESHVHDVTITKEAPNY  IMDH_ACICA  
Q9RHG1     :           TFDDVLLVPAKS--DVLPREVSVKTVL-------SESLQLNIPLISAGMDTVTEADMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRISGVPVVNN-LDERKLVGIITNRDMRF-IQDYSIKISDVMTK-EQLITAPVGTTLDEAEKILQKYKIEKLPLVDNNGVLQGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAMTRIDALVKASVDAIVLDTAHGHSQGVIDKVKEVRAKY-PSLNIIAGNVATAEATGALIEAGANVVKVGIGPGSICTTRVVAGVGVPQLTAVYDCATEARKH------GIPVIADGGIKYSGDMVKALAAGAHVVMLGSMFAGVAESPGETEIYQGRQFKVYRGMGSVGAMEKGSKDRYFQEGNKKL-VPEGIEGRVPYKGPLADTVHQLVGGLRAGMGYCGAQDLEFLRENAQFVRMSGAGLLESHPHHV  Q9RHG1  
IMD1_HUMAN :           TYNDFLILPGF--IDFIADEVDLTSALTR-------KITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKNFEQGFITDPVVLSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRD--IDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKY-PHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVA----EYARRFG--VPIIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKFEKRTMSAQIEGGVH  IMD1_HUMAN  
Q9JZB5     :       EKAYTFDDVLLVPAHSTV--LPRDVKLQTKLTR-------EITLNLPLLSAAMDTVTEARLAISMAQEGGIGIIHKNMPPEMQARAVSKVKRHESGVVKDPVTVAPTTLIREVLEMRAQRKRKM-----SGLPVVENGKVVGIVTNRDLRFE-NRVDLPVSAIMTPRERLVTVPEGTSIDEARELMHTHKVERVLVLNEKDELKGLITVKDILKTTEFPNANKDSEGRLRVGAAVGTGGDTEERVKALVEAGVDVIVVDTAHGHSQGVIDRVRWVKETY-PHIQVIGGNIATAKAALDLVAAGADAVKVGIGPGSICTTRIVAGVGVPQLTAIHN-VAEALK-----GTGVPLIADGGIRFSGDIAKALAAGAYSVMLGGMFAGTEEAPGEIELYQGRSYKSYRGMGSLGAMSQGSADRYFQDKTDSTDKYVPEGIEGRVPYKGPIVNIIHQLTGGLRSSMGYLGCANIAEMHEKAEFVEITSAGMSESHVHDVQITKEAPNYH  Q9JZB5  
Q9JUD0     :       EKAYTFDDVLLVPAHSTV--LPRDVKLQTKLTR-------EITLNLPLLSAAMDTVTEARLAISMAQEGGIGIIHKNMPPEMQARAISKVKRHESGVVKDPVTVAPTTLIREVLEMRAQRKRKM-----SGLPVVENGKVVGIVTNRDLRFE-NRVDLPVSAIMTPRERLVTVPEGTSIDEARELMHTHKVERVLVLNEKDELKGLITVKDILKTTEFPNANKDSEGRLRVGAAVGTGGDTEERVKALVEAGVDVIVVDTAHGHSQGVIDRVRWVKETY-PHIQVIGGNIATAKAALDLVAAGADAVKVGIGPGSICTTRIVAGVGVPQLTAIHN-VAEALK-----GTGVPLIADGGIRFSGDIAKALAAGAYSVMLGGMFAGTEEAPGEIELYQGRSYKSYRGMGSLGAMSQGSADRYFQDKTDSADKYVPEGIEGRVPYKGPIVNIIHQLTGGLRSSMGYLGCANIAEMHEKAEFVEITSAGMSESHVHDVQITKEAPNYH  Q9JUD0  
IMDH_BACSU :           TFDDVLLVPAKSEV--LPHDVDLSVELTKTLK-------LNIPVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFLTPDHQVFDAEHLMGKYRISGVPIVNNEEDQ-KLVGIITNRDLRF-ISDYSMKISDVMTK-EELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIHGRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETY-PELNIIAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGK------TIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMGSVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKDLRALREEAQFIRMTGAGLRESHPHDV  IMDH_BACSU  
Q9RHG9     :           TFDDVLLVPARS--DILPREVSVKTVL-------SESLQLNIPLISAGMDTVTEADMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRISGVPVVNN-LDERKLVGIITNRDMRF-IQDYSIKISDVMTK-EQLITAPVGTTLEEAEKILQKYKIEKLPLVDNNGVLQGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAYLRIDALVKASVDAIVLDTAHGHSKGVIDKVKEVRAKY-PSLNIIAGNVATAEATKALIEAGENVVKVGIGPGSICTTRVVAGVGVPQLTAVYDCATEARKH------GIPVIADGGIKYSGDMVKALAAGAHVVMLGSMFAGVAESPGETEIYQGRQFKVYRGMGSVGAMEKGSKDRYFQEGNKKL-VPEGIEGRVPYKGPLADTVHQLVGGLRAGMGYCGAQDLEFLRENAQFIRMSGAGLRESHPHHV  Q9RHG9  
Q9L0I7     :           TYDDVLLLPGASAV--LPNAVDTSSRISR-------NVRVNIPLLSAAMDKVTESRMAISMARQGGVGVLHRNLSIEDQANQVDLVKRSESGMVANPITIHPDATLGEADALCAKFRISGVPVTDGA---GKLLGIVTNRDMAFE-TDRSRQVREVMTPM-PLVTGQVGISGVDAMELLRRHKIEKLPLVDGDGILKGLITVKDFVKAEQYPHAAKDAKGRLLVGAAVGASPEALDRAQALAEAGVDFLVVDTSHGHNSNALSWMSKIKSSVG--IDVVGGNVATRDGAQALIDAGVDGIKVGVGPGSICTTRVVAGIGVPQVTAIYEASLAAR-------AAGVPLIGDGGLQYSGDIGKALAAGADTVMLGSLLAGCEESPGELQFINGKQFKSYRGMGSLGAMQSRGQGRSYSKDRYFQAEVASDDKL-VPEGIEGQVPYRGPLANVLHQLVGGLRQTMGYVGAATIEEMESKGRFVRITSAGLKESHPHDI  Q9L0I7  
Q9PAR5     :           TYDDVSLVPSHSTV--LPKDVNLETRLTR-------NIRLKLPVLSAAMDTVTEARLAIVMAQLGGIGIIHKNLTIEQQVAEVTKVKKYESGVIRDPITVDPETSIRDVLALTRAKNISGVPVVDKGQ----LIGLVTHRDMRFE-SELDDPVRHIMTKKEALVTVKEGADSQEVLQLLHKHRIEKILVVNDAFELRGLITVKDIQKKSDYPNAAKDAVTRLLVGAAVGVGGETERRVETLAAAGVDVIIVDTAHGYSQGVLDRVAWIK-RYFPQLQVIGGNIVTGDAALALMDAGADAVKVGVGPGSICTTRMVAGVGVPQITAVQMVSDALQDR----------IPLIADGGIRYSGDIGKALAAGASTVMIGGLFAGTEEAPGDVELFQGRTYKSYRGMGSLAAMEKGSKDRYFQEASDVDKL-VPEGIEGRVPYRGSVSGIVHQLMGGLRATMGYVGCATIEEMRTKPQFVKITGAGQVESHVHDVQITKEPPNY  Q9PAR5  
IMDH_MYCTU :           TFDDVLLLPAAS--DVVPATADTSSQLTK-------KIRLKVPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVVDD---DGALVGIITNRDMRFEVDQSK-QVAEVMTK-APLITAQEGVSASAALGLLRRNKIEKLPVVDGRGRLTGLITVKDFVKTEQHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKSEVGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEAVAACRP------AGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQYKSYRGMGSLGAMRGRGGATSYSKDRYFADDALSEDKL-VPEGIEGRVPFRGPLSSVIHQLTGGLRAAMGYTGSPTIEVLQ-QAQFVRITPAGLKESHPHDVAMTVEAPNYYAR  IMDH_MYCTU  
IMDH_MYCLE :           TFDDVLLLPAAS--DVVPATADISSQLTK-------KIRLKVPLVSSAMDTVTEARMAIAMARAGGMGVLHRNLPVGEQAGQVETVKRSEAGMVTDPVTCRPDNTLAQVGALCARFRISGLPVVDDS---GALAGIITNRDMRFEVDQSK-QVAEVMTK-TPLITAAEGVSADAALGLLRRNKIEKLPVVDGHGRLTGLITVKDFVKTEQHPLATKDNDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLIVDTAHAHNRLVLDMVGKLKVEIGDRVQVIGGNVATRSAAAALVEAGADAVKVGVGPGSTCTTRVVAGVGAPQITAILEAVAACGP------AGVPVIADGGLQYSGDIAKALAAGASTTMLGSLLAGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRGGDKSYSKDRYFADDALSEDKL-VPEGIEGRVPFRGPLSSVIHQLVGGLRAAMGYTGSPTIEVLQ-QAQFVRITPAGLKESHPHDVAMTVEAPNYYPR  IMDH_MYCLE  
Q9PNN3     :           TFEDVLLRPGYSEV--LPKEVKIHTKLTK-------NITLNMPLISAAMDTVTEHRAAIMMARLGGLGVIHKNMDIASQVREVKRVKKSESGVIIDPIFVSPKASVAEALEIMAEYRISGVPVVDEDKK---LIGILTNRDLRFE-SDFSNLVENVMTKM-PLITAPKGCTLDDAEKIFSTNKVEKLPIVDEQGRLEGLITIKDLKKRKEYPDANKDNFGRLRVGAAIGVGQM-DRVDALVEAGVDVVVLDSAHGHSKGIIDTVKAIKAKY-PNLDLIAGNIATAAAAKALCEAGVDAVKVGIGPGSICTTRIVSGVGVPQISAIDECVEEANKF------GVPVIADGGIKYSGDIAKALAVGASSVMIGSLLAGTDESPGELFTYQGRQYKSYRGMGSLGAMQKGSSDRYFQQGTAQDKLVPEGIEGRVPYVGSIRSVVHQLLGGLRSSMGYVGAKDIEDFQKRAEFVEITTAGLKESHVHDVTITHEAPNY  Q9PNN3  
O96387     :                          CMPGYIDFALSDIDLTNNMTDNITLKTPVISSPMDTVTGHKMSIALALSGGLGVIHNNMSIEKQIEEVKKVKRFENGFIFDPYTFSPEHTVADVLETKNRVGYKSYPITVDGKVGSKLVGIITGIDY-LYLTNKSMKIGDIMT--TDVVTGSYPINLSDANKVLCDEKKSVLPIVNKNNELIALVCRNDMHKNRIFPHASKSQNKQLIVGASISTREHDLERANQLIKNMIDVICIDSSQGNSIYQIDTIKKIKSAHPD-IPIIGGNVVTSQQAKNLIDAGADVLRIGMGSGSICTTQDVCAVGRAQGTAVYHV----SKYAHTRN--IKTIADGGIKNSGNIVKALSLGADFVMLGNLLAATEESCSEYYFENNVRLKIYRGMGSMEAMYNKGFNSKSRYLVDERKNEYTDENIDEIKVSQGVSASLVDKGSVLNLIPHLFKAVKHGFQSMGIRNIPELHSK  O96387  
IMDH_STRPY :          YTFDDVLLIPAESHV--LPNEVDLKTKLA-------DNLTLNIPIITAAMDTVTGSKMAIAIARAGGLGVIHKNMSITEQAEEVRKVKRSENGVIIDPFFLTPEHKVSEAEELMQRYRISGVPIVET-LANRKLVGIITNRDMRF-ISDYNAPISEHMTS-EHLVTAAVGTDLETAERILHEHRIEKLPLVDNSGRLSGLITIKDIEKVIEFPHAAKDEFGRLLVAAAVGVTSDTFERAEALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPNRTLI-AGNIATAEGARALYDAGVDVVKVGIGPGSICTTRVVAGVGVPQVTAIYDAAAVAREYGK------TIIADGGIKYSGDIVKALAAGGNAVMLGSMFAGTDEAPGETEIYQGRKFKTYRGMGSIAAMKKGSSDRYFQGSVNEANKLVPEGIEGRVAYKGAASDIVFQMLGGIRSGMGYVGAGDIQELHENAQFVEMSGAGLIESHPHDVQITNEAPNY  IMDH_STRPY  
IMD1_MOUSE :           TYNDFLILPGF--IDFIADEVDLTSALTR-------KITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKIQHGFSGIPITATGTMGSKLVGIVTSRD--IDFLAEKDHTTLLSEVMTPRVELVVAPAGVTLKEANEILQRSKKGKLPIVNDQDELVAIIARTDLKKNRDYPLASKDSHKQLLCGAAVGTREDDKYRLDLLTQAGADVIVHDSSQGNSVYQIAMVHYIKQKY-PHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVA----EYARRFG--VPVIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGIGSLDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGAQSLSVLRSMMYSGELKFEKRTMSAQIEGGVH  IMD1_MOUSE  
IMDH_METJA :          YTFDDVLLVPNASWVE--PKDTDVSTDL--------AGLKLNIPIVSAAMDTVTEKEMAIALARLGGLGVIHRNMSIEEQVHQVQAVKKADEVVIKDVITVSPDDTVGEAINVMETYSISGLPVVDN---EDKLVGIITHRDVKAIEDKTK-KVKDVMT--KDVVCAKEDVEEEEALELMYANRVERLPIVDDENRLIGIITLRDILKRRKYPQAARDKKGRLLVAAACGPHDF-ERAKALIEAEVDAIAIDCAHAHNMRVVENVKKFKEMLEGTDIKLIVGNIATKEAAEDLIKAGADVLKVGIGPGSICTTRVVAGVGVPQLTAVAEVADVAKEHN---------VPIIADGGIRYSGDIAKAIAAGADAVMLGSLLAGTDEAPGQLMVINGRKYKQYRGMGSLGAMTGGVGAGADRYFQAPAKSHMKHVKLVPEGVEGAVPYKGPVSEVVFQLIGGLRASMGYCGAKNLKEMQEKARFVIITPSGQVESHPHDIIITNEAPNY  IMDH_METJA  
IMDH_DROME :           TYNDFLILPGY--IDFTAEEVDLSSPLTK-------SLTLRAPLVSSPMDTVTESEMAIAMALCGGIGIIHHNCTPEYQALEVHKVKKYKHGFMRDPSVMSPTNTVGDVLEARRKNGFTGYPVTENGKLGGKLLGMVTSRDIDFRENQPEVLLADIMT--TELVTAPNGINLPTANAILEKSKKGKLPIVNQAGELVAMIARTDLKKARSYPNASKDSNKQLLVGAAIGTRSEDKARLALLVANGVDVIILDSSQGNSVYQVEMIKYIKETYPELQVIG-GNVVTRAQAKNLIDAGVDGLRVGMGSGSICITQEVMACGCPQATAVYQV----STYARQFG--VPVIADGGIQSIGHIVKAIALGASAVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMERGDAKGAAMSRYYHNEMDKMKVAQGVSGSIVDKGSVLRYLPYLECGLQHSCQDIGANSINKLRDMIYN  IMDH_DROME  
Q9CIY6     :           TFDDVLLIPAESHV--LPNEVSMKTKLAK-------NLTLNIPIISAAMDTVTDSKMAISMARQGGLGVVHKNMSVEEQAEEIHKVKRSESGVITDPFFLTPNHKIEEAENLMATYRISGVPIVDT-LENRKLVGIITNRDLRF-ITDYNQQIKNMMTS-ENLITAPVGTTLDTAARILQEHKIEKLPLVDEAGKLAGLITIKDIERVIEFPNAAKDEQGRLLVAGAVGVSSDTFERAEALFAAGADAIVIDTAHGHSAGVLRKIREIRNHFPDRTLI-AGNIATGEGARALFEAGVDVVKVGIGPGSICTTRVVAGVGVPQITAIYD-AANVAREFGKT-----IIADGGIKYSGDIVKALAAGGDAVMLGSMLAGTDESPGEFEIFQGRKFKTYRGMGSLAAMKKGSKDRYFQGAVNEANKLVPEGIEGRVAYKGTATDIVFQMLGGLKAGMGYTGAADITALHDSAQFIEMSGAGLKESHPHDVQITKEAPNY  Q9CIY6  
IMDH_HELPJ :           TFEDVLMVPRKSSV--LPKDVSLKSRLTK-------NIGLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIQTQVKEITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGVPVVDD---KGLLIGILTNRDVRFE-TDLSKKVGDVMTKM-PLVTAHVGISLDEASDLMHKHKIEKLPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQL-DRAEMLVKAGVDALVLDSAHGHSANILHTLEEIKKSL--VVDVIVGNVVTKEATSDLISAGADAVKVGIGPGSICTTRIVAGVGMPQVSAIDNCVEVASKF------DIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQEGVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY  IMDH_HELPJ  
IMDH_HELPY :           TFEDVLMVPRKSSV--LPKDVSLKSRLTK-------NIRLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIQTQVKEITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGVPVVDD---KGLLIGILTNRDVRFE-TDLSKKVGDVMTKM-PLVTAHVGISLDEASDLMHKHKIEKLPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQL-DRAEMLVKAGVDALVLDSAHGHSANILHTLEEIKKSL--VVDVIVGNVVTKEATSDLISAGADAIKVGIGPGSICTTRIVAGVGMPQVSAIDNCVEVASKF------DIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQEGVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY  IMDH_HELPY  
Q9P8J2     :           TYNDFLILPGL--VNFPSSAVSLETKLTK-------KITLKSPFVSSPMDTVTEENMAIHMALLGGIGIIHHNCTAEEQAEMVRKVKKYENGFINDPVVISPEVTVGEVKKMGEVLGFTSFPVTENGKVGGKLVGIITSRDIQFH-EDNKSPVSEVMT--KDLVVGKKGISLTDGNELLRSSKKGKLPIVDAEGNLVSLISRTDLQKNQDYPNASKSFHSKQLLCGAAIGTIDADRERLDKLVEAGLDVVVLDSSNGSSVFQLNMIKWIKEKY-PELQVIAGNVVTREQAALLIEAGADALRIGMGSGSICITQEVMACGRPQGTAVYGVTEFANKF------GVPCIADGGIGNIGHITKALALGASCVMMGGLLAGTAETPDDYFYRDGKRLKTYRGMGSIDAMQQTNTNANASTSRYFSEADKVLVAQGVSGSVVDKGSITKFVPYLYNGLQHSLQDIGIKSIDELRENVDNGEIRFEFRTASAQFEGGVH  Q9P8J2  
Q9RT87     :           TFDDVLLQPRHSQV--LPHEVDVSAQLTR-------RVRLNIPFVSAAMDTVTETNMAIAMAREGGIGVVHKNMSIDAQAEMIRKVKRSESGMIVDPITLPPSATVRDADRLMGEYRISGVPVT---APDGKLLGIITNRDMRF-IDDLDVPLGDVMTR-EHLVTVPVGTDLEQARELFKLNRIEKL-LVTEGEYLRGLITIKDIEKSVKYPNAAKDDLGRLRVAAAIGVSADLMDRAGALVQAGADVLVLDSAHGHSQGILNALSRVKEQF--DVDVIAGNVATRSGARDLILAGADAVKVGIGPGSICTTRVVTGVGVPQVTAIFEASAAA----MEAG--IPVIADGGIKQTGDVPKAIAAGASVVMMGSMLAGTDEAPGETILRDGRRYKSYRGMGSLGAMDQGSADRYFQGGSRKF-VPEGIEGIIAYRGTAGEVIYQFVGGLKSSMGYCGAPDLTTLRDTAQFVRITGASLVESHPHGVTITKEAPNY  Q9RT87  
IMH3_CANAL :           TYNDFLILPGL--INFPSSAVSLETKLTK-------KITLKSPFVSSPMDTVTEENMAIHMALLGGIGIIHHNCTSEEQAEMVRKVKKYENGFINDPVVISPEVTVGEVKKMGEVLGFTSFPVTENGKVGGKLVGIITSRDIQFH-EDNKSPVSEVMT--KDLVVGKKGISLTDGNELLRSSKKGKLPIVDAEGNLVSLISRTDLQKNQDYPNASKSFHSKQLLCGAAIGTIDADRERLDKLVEAGLDVVVLDSSNGSSVFQLNMIKWIKEKY-PELQVIAGNVVTREQAALLIEAGADALRIGMGSGSICITQEVMACGRPQGTAVYGVTEFANKF------GVPCIADGGIGNIGHITKALALGASCVMMGGLLAGTAETPGDYFYRDGKRLKTYRGMGSIDAMQQTNTNANASTSRYFSEADKVLVAQGVSGSVVDKGSITKFVPYLYNGLQHSLQDIGIKSIDELRENVDNGEIRFEFRTASAQFEGGVH  IMH3_CANAL  
O14344     :           TFNDFLILPGY--IDFVPNNVSLETRISR-------NIVLKTPFMSSPMDTVTEDQMAIYMALLGGIGVIHHNCTPEEQAAMVRKVKKYENGFILDPVVFSPQHTVGDVLKIKETKGFSGIPITENGKLRGKLVGIVTSRDVQFH-KDTNTPVTEVMTPREELITTAEGISLERANEMLRKSKKGKLPVVDKDDNLVALLSLTDLMKN--LHFPLASKTSDTKQLMVAAAIGTRDDDRTRLALLAEAGLDAVVIDSSQGNSCFQIEMIKWIKKTY-PKIDVIAGNVVTREQTASLIAAGADGLRVGMGSGSACITQEVMACGRPQATAIAQVAEFASQF------GIGVIADGGIQNVGHMVKSLSLGATAVMMGGLLAGTTESPGEYYVREGQRYKSYRGMGSIAA  O14344  
Q9RHZ0     :           TFDDVLLLPAESNV--VPSEVDTSAQFTR-------NTRLGIPLASAAMDTVTEARMAIAMARQGGIGVLHRNLSSQEQAEQVEIVKRSESGMVTDPVTANPDMTIQEVDDLCARFRISGLPVVNE---DGTLLGICTNRDMRFERDYSR-KVSDIMTAM-PLVVAKEGVSKEEALDLLSTNKVEKLPIVDKNNKLVGLITVKDFVKTEQFPNSSKDASGRLLVAAGIGTGEESYERAGLLVDAGVDVLIVDSAHAHNNRVLEMVSRVKNDFGSKIDVVGGNLATRSAAKAMIEAGADAIKVGIGPGSICTTRVVAGVGAPQITAIMEAAT------VASAAGVPLIADGGMQYSGDVAKALAAGADSVMLGSMFAGTLEAPGDIVIVGGKQYKRYRGMGSMGAMQGRGLSGEKRSYSKDRYFQADVRSEDKL-VPEGVEGKVPYRGEIGQITHQIVGGLRAAMGYTGSATIEELKTK-QFVRITTAGLAESHPH  Q9RHZ0  
IMD2_HUMAN :           TYNDFLILPGY--IDFTADQVDLTSALTK-------KITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRD--IDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIG-GNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKV----SEYARRFG--VPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSL  IMD2_HUMAN  
IMD2_MOUSE :           TYNDFLILPGY--IDFTADQVDLTSALTK-------KITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRD--IDFLKEEEHDRFLEEIMTKREDLVVAPAGVTLKEANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLALAGVDVVVLDSSQGNSIFQINMIKYIKEKY-PSLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKV----SEYARRFG--VPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMTYSGELKFEKRTSSAQVEGGVHSL  IMD2_MOUSE  
IMH2_YEAST :           TYNDFLVLPGL--VDFPSSEVSLQTKLTR-------NITLNTPFVSSPMDTVTESEMAIFMALLGGIGFIHHNCTPEDQADMVRRVKNYENGFINNPIVISPTTTVGEAKSMKERFGFSGFPVTEDGKRNGKLMGIVTSRDIQF-VEDNSLLVQDVMT--KNPVTGAQGITLSEGNEILKKIKKGKLLIVDDNGNLVSMLSRTDLMKNQ---NYPLASKSATTKQLLCGAAIGTIDADKERLRLLVEAGLDVVILDSSQGNSIFQLNMIKWIKETFPD-LEIIAGNVATREQAANLIAAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVCEFANQF------GIPCMADGGVQNIGHITKALALGSSTVMMGGMLAGTTESPGEYFYQDGKRLKAYRGMGSIDAMQKTGTKGNASTSRY-FSESDSVLVAQGVSGAVVDKGSIKKFIPYLYNGLQHSCQDIGYKSLTLLKENVQSGKVRFEFRTASAQLEGGVHNL  IMH2_YEAST  
IMD2_MESAU :           TYNDFLILPGY--IDFTADQVDLTSALTK-------KITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRD--IDFLKEEEHDRFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLALAGVDVVVLDSSQGNSIFQINMIKYMKEKYPNLQVIG-GNVVTAAQAKNLIDAGVDALRVGMGCGSICITQEVLACGRPQATAVYKV----SEYARRFG--VPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSL  IMD2_MESAU  
Q9UVL0     :           TYNDIIILPGY--IDFEVNSVSLESHITK-------KIVLKTPFMSSPMDTVTESDMAINLALLGGIGVIHHNCTIEEQTEMVRKVKKFENGFITSPIVLSLNHRVRDVRRIKEELGFSGIPITDTGQLNGKLLGIVTSRDIQFH-NNDESFLSEVMT--KDLVTGSEGIRLEEANEILRSCKKGKLPIVDKEGNLTALLSRSDLMKNLHFPLASKLPDS-KQLICAAAVGTRPDDRIRLKHLVEAGLDIVVLDSSQGNSIYQINMIKWIKKEF-PNLEVIAGNVVTREQAANLISAGADALRVGMGSGSICITQEIMAVGRPQATAVYAVSEFASKF------GVPTIADGGIENIGHITKALALGASAVMMGNLLAGTTESPGQYYYRDGQRLKSYRGMGSIDAME----HLSGKNK  Q9UVL0  
Q9GZH3     :           TYNDFNILPGF---------INFGVHDVSLETNITKDLKIKAPLVSSPMDTVTESGMAIVMALYGGIGIIHGNFPKPEDQAAEVLKVKRFKQGYVMQPHCLSRDSTAFDMIQIKKKYGYTGAPVTEDGRVGSKLIGMVTSRDFDFITMDVAGQKGTPISDIMVSVDQLHLGHINDAPELSQKKLKEHRLGKLPIVNDNGELCALLCRSDLLKARDYPMASYDSKGQLLCGAAVNTRGESQYTVDRVVEAGVDVLIIDSSNGSSTYQISMLRYIKEKH-PHVQVIAGNVVTRAQAKLLIDQGADGLRIGMGSGSICITQDVMAVGRAQGTAVYDVA----RYANQRG--IPIVADGGIRDVGYITKAISLGASAVMMGGLLAATTEAPG----------EYFWGPGGS-------FNFSESDQIKVAQGVSATMKDRGSCHKFIPYLIRGVQHGMQDIGVRSLRDFREKVDNGIVKFERRSTNAQLEGGVHSL  Q9GZH3  
Q9KH33     :           TFDDVLLQPGHSEV--MPGQTNIATRIAQ-------DIELNVPILSAAMDTVTESRLAIAMAQAGGMGVIHRNLTPVQQAEEVRQVKKFESGMVVNPVTIGPDATLAEALSLDEGPRHFRASPVVEKSHR--LVGILTNRDVRF-ASDPEQKIYELMTR-ENLVTVKDGVQQHEAKRLLHTHRIEKXLVVDADSRFVGLITVKDIEKSQLNPHASKDAQGRLRAAAAISVGDDGYERAERLIDAGVDLLVVDTAHGHS--QRVLDAVTRVKKLSNSVRIMAGNVATYDGTRALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLAAIMSAVQAAQDQ------NIPIIADGGIKFSGDLAKAIAAGASAAMIGSLLAGTDESPGEVYLYQGRSFKAYRGMGSVGAMARGSADRYFQAEVRDTLKL-VPEGIEGXVPYKGPVSGVLHQLAGGLKAAMGYVGGADLKDFQERATFVRISGAGLRESHAHDVTITPR  Q9KH33  
IMH3_YEAST :           TYNDFLVLPGL--VNFPSSAVSLQTKLTK-------KITLNTPFVSSPMDTVTEADMAIYMALLGGIGFIHHNCTPKEQASMVKKVKMFENGFINSPIVISPTTTVGEVKVMKRKFGFSGFPVTEDGKCPGKLVGLVTSRDIQF-LEDDSLVVSEVMT--KNPVTGIKGITLKEGNEILKQTKKGKLLIVDDNGNLVSMLSRADLMKNQ---NYPLASKSATTKQLLCGAAIGTIEADKERLRLLVEAGLDVVILDSSQGNSVFQLNMIKWIKETFPD-LEIIAGNVATREQAANLIAAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVCQFANQF------GVPCMADGGVQNIGHITKALALGSSTVMMGGMLAGTTESPGEYFYKDGKRLKAYRGMGSIDAMQKTGNKGNASTSRY-FSESDSVLVAQGVSGAVVDKGSIKKFIPYLYNGLQHSCQDIGCESLTSLKENVQNGEVRFEFRTASAQLEGGVHNL  IMH3_YEAST  
IMH1_YEAST :           TYNDFLILPGL--VDFASSEVSLQTKLTR-------NITLNIPLVSSPMDTVTESEMATFMALLGGIGFIHHNCTPEDQADMVRRVKNYENGFINNPIVISPTTTVGEAKSMKEKYGFAGFPVTTDGKRNAKLVGVITSRDIQF-VEDNSLLVQDVMT--KNPVTGAQGITLSEGNEILKKIKKGRLLVVDEKGNLVSMLSRTDLMKNQ---NYPLASKSANTKQLLCGASIGTMDADKERLRLLVKAGLDVVILDSSQGNSIFELNMLKWVKESF-PGLEVIAGNVVTREQAANLIAAGADGLRIGMGTGSICITQEVMACGRPQGTAVYNVCEFANQF------GVPCMADGGVQNIGHITKALALGSSTVMMGGMLAGTTESPGEYFYQDGKRLKAYRGMGSIDAMQKTGTKGNASTSRY-FSESDSVLVAQGVSGAVVDKGSIKKFIPYLYNGLQHSCQDIGCRSLTLLKNNVQRGKVRFEFRTASAQLEGGVHNL  IMH1_YEAST  
IMDH_LEIDO :           TYNDFIILPGF--IDFGAADVNISGQFTK-------RIRLHIPIVSSPMDTITENEMAKTMALMGGVGVLHNNCTVERQVEMVKSVKAYRNGFISKPKSVPPNTPISNIIRIKEEKGISGILVTENGDPHGKLLGIVCTKD--IDYVKNKDTPVSAVMTRREKMTVERAPIQLEEAMDVLNRSRYGYLPIVNENDEVVNLCSRRDAVRARDYPHSTLDKSGRLICAAATSTRPEDKRRVAALADVGVDVLVLDSSQGNTIYQIAFIKWVKSTY-PHLEVVAGNVVTQDQAKNLIDAGADGIRIGMGSGSICITQEVLACGRPQGTAVYKVA----QYCASRG--VPCTADGGLRQVGDICKALAIGANCAMLGGMLSGTTETPGEYFFKGGVRLKVYRGMGSLEAMSQGKE--SGKRYLSENEAVQVAQGVSGNVVDKGSAA  IMDH_LEIDO  
IMDH_PYRFU :          YTFDDVLLIPQPTEVE--PKDVDVSTQITP-------NVKLNIPILSAAMDTVTEWEMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKRAERFIVEDVITIAPDETIDYALFLMEKHGIDGLPVVEEDR----VVGIITKKDIAAREGRT---VKELMT--REVITVPESVDVEEALKIMMENRIDRLPVVNEDGKLVGLITMSDLVARKKYKNAVRNEKGELLVAAAVSPFDLR-RAIELDRAGVDVIVVDTAHAHNLKAIKAMKEMRQKVSADFIV--GNIANPKAVDDL--TFADAVKVGIGPGSICTTRIVAGVGVPQITA-IAMVADR---AQEYGLY--VIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNY  IMDH_PYRFU  
Q9UY49     :          YTFDDVLLIPQATEVE--PKDVDVSTQITP-------NVKLNIPILSAAMDTVTEWEMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEK----VVGIISKK----DIAAREGKLVKELMT--KDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIR-RAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKVDADFIV--GNIANPKAVDDL--TFADAVKVGIGPGSICTTRIVAGVGVPQITA-IAMVADR---AQEYGLY--VIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNY  Q9UY49  
Q9HQU4     :           TFDDVLLRPAESRVE--PDDADVATRV-------STNVELEVPVLSAAMDTVTESRLAIAMAREGGLGVLHQNMDTDRVVAEVERVKRADE-LVIDRENVVTAAPEQTVEAVDEMMDRSDVSGAPVVDDDDTVRGIISATDIRPY-LEVGESDA-VREAMT--DEVITAPEDITARDALELMYEHKIERVPIVNDEQHLVGLVTMQGILERREHGSAARDQNGRLRVGVAVGPFD-TERATAVDEAGADVLFIDCAHAHN------LNVIDSAREIKASVDADVVVGNVGTREAAEAVVDFADGIKVGIGPGSICTTRVVTGSGMPQITAVSQVADVAAPAG---------VPVIADGGIRYSGDAAKAIAAGADAVMLGSYFAGTDEAPGRVITMNGKKYKQYRGMGSVGAMQSGGSDRYLKDDDEDEEYVPEGVEAATPYKGSLASELHQLVGGIQSGMGYVGAESIPAFKADAEFVRVSAAGQTEGHPHDVMITDEAPNYSPQ  Q9HQU4  
IMDH_TRYBB :           SFNDFIILPGF--IDFDSSKVNVSGQFTK-------NILLHLPLVSSPMDTVTESSMARAMALMGGIGVIHNNCTVEQQARMVRSVKLYRNGFIMKPKSVSPDVPVSTIRNIKSEKGISGILVTEGGKYDGKLLGIVCTKDIDF-VKDASAPVSQYMTRRENMTVERYPIKLEEAMDVLNRSRHGYLPVLNDKDEVVCLCSRRDAVRARDYPNSSLDRNGHLLCAAATSTREADKGRVAALSEAGIDVLVLDSSQGNTIYQVSFIRWVKKTY-PHLEVVAGNVVTQDQAKNLIDAGADSLRIGMGSGSICITQEVLACGRPQATAIYKVA----RYAASRG--VPCVADGGLRNVGDVCKALAVGANVAMLGSMIAGTSETPGEYFFKDGMRLKGYRGMGSIDAMLQGRE--SGKRYLSENETLQVAQGVAGAVLD  IMDH_TRYBB  
IMDH_PYRHO :