Christine Vogel1*, Carlo Berzuini2,3
Matthew Bashton1, Julian Gough4 and Sarah A. Teichmann1*
1MRC Laboratory of Molecular
Biology, Hills Road, Cambridge CB2 2QH, UK,
2MRC Biostatistics Unit,
Institute of Public Health, Cambridge CB2 2SR, UK,
3Dipartimento di Informatica
e Sistemistica, University of Pavia, 27100 Pavia, Italy
and 4Genome
Exploration Research Group, RIKEN Genomic Sciences Centre, W121 1-7-22
Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan & Department of
Structural Biology, Fairchild bldg, D109, Stanford, CA 94305-5126, U.S.A.
*Corresponding authors: cvogel {at} mrc-lmb.cam.ac.uk, sat {at} mrc-lmb.cam.ac.uk
Versatility measure in average number of domain partners
Average number of domain partners
|
Single domains
|
All two-domain combinations
|
Two-domain supra-domains
|
Over-represented two-domain supra-domains
|
Top 200 most versatile
supra-domains
|
Top 200 most duplicated
supra-domains
|
|||||
Whole domain/combination
|
|||||||||||
N- and C-terminus
|
20.7
|
3.0
|
|
5.5
|
|
7.2
|
|
14.0
|
|
12.8
|
|
N-terminus
|
10.4
|
1.5
|
|
2.8
|
|
3.7
|
|
7.5
|
|
7.0
|
|
C-terminus
|
10.3
|
1.4
|
|
2.7
|
|
3.5
|
|
6.5
|
|
5.6
|
|
PCC
(N- vs C-terminus)
|
0.989
|
0.832
|
|
0.801
|
|
0.805
|
|
0.847
|
|
0.884
|
|
N-terminal domain
|
|||||||||||
N- and C-terminus
|
|
78.1
|
22.0
|
94.0
|
30.1
|
76.1
|
33.0
|
95.4
|
63.0
|
80.8
|
51.3
|
N-terminus
|
|
39.6
|
11.0
|
48.4
|
15.1
|
39.1
|
16.5
|
49.8
|
32.5
|
41.4
|
26.2
|
C-terminus
|
|
38.5
|
11.0
|
45.6
|
15.0
|
36.9
|
16.4
|
45.6
|
30.4
|
39.4
|
25.1
|
C-terminal domain
|
|||||||||||
N- and C-terminus
|
|
82.3
|
21.8
|
101.1
|
29.6
|
76.9
|
32.4
|
94.5
|
60.1
|
78.7
|
50.5
|
N-terminus
|
|
43.5
|
11.1
|
54.0
|
15.0
|
40.5
|
16.4
|
49.6
|
30.8
|
40.1
|
25.6
|
C-terminus
|
|
38.8
|
10.8
|
47.1
|
14.6
|
36.4
|
16.0
|
44.9
|
29.3
|
37.8
|
24.9
|
PCC
(N- vs C-terminal domain)
|
|
-0.107
|
|
-0.044
|
|
-0.015
|
|
0.189
|
|
0.1.74
|
|