Supra-domains – evolutionary units larger than single protein domains

Christine Vogel¹*, Carlo Berzuini^2,3 Matthew Bashton¹, Julian Gough⁴ and Sarah A. Teichmann¹*

¹MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK,

²MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR, UK,

³Dipartimento di Informatica e Sistemistica, University of Pavia, 27100 Pavia, Italy

and ⁴Genome Exploration Research Group, RIKEN Genomic Sciences Centre, W121 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan & Department of Structural Biology, Fairchild bldg, D109, Stanford, CA 94305-5126, U.S.A.

*Corresponding authors: cvogel {at} mrc-lmb.cam.ac.uk, sat {at} mrc-lmb.cam.ac.uk

Coverage

	Number	Sequences %	Domain architectures %	Domain combinations %
Two-domain combinations
All	9,398	44	72
in PDB	616	30	31	63
not in PDB	8,782	18	55	37
Supra	2,368	40	54
in PDB	491	29	31	62
not in PDB	1,877			28
Over-represented	1,203	38	47	84
in PDB	456	29	31	61
not in PDB	747	11	25	23
Top 200 most duplicated	200	28	27
in PDB	161			48
not in PDB	39			8
Top 200 most versatile	200	12	30
in PDB	99			31
not in PDB	101			8
Three-domain combinations
All	4,323	12	30
in PDB	217	7	10
not in PDB	4106	7	24
Supra	935	10	22
in PDB	150	6	10
not in PDB	785	5	15
Over-represented	166	3	9
in PDB	37	2	5
not in PDB	129	1	6
Top 200 most duplicated	200
in PDB	107	6	10
not in PDB	93	3	7
Top 200 most versatile	200
in PDB	45	4	8
not in PDB	155	2	8