| Sarah Teichmann | |
Computational Genomics
Current Status of the Structural Annotation of the Mycoplasma genitalium Genome |
Using computational methods, we are trying to gain a better understanding of how cells and organisms work and how they have evolved. Our analyses and calculations involve the gene and protein sequences from genome projects as well as proteomics and functional genomics data. Most of our work is done from a structural perspective so that we can draw on the evolutionary information inherent in the growing number of protein structures. In particular, we are currently interested in gaining insight into the organisation of protein domains in genome sequences, in metabolic pathways and in protein-protein interactions. This will allow us to start mapping out how protein families have evolved in the context of their functional and structural neighbours.
Glycogen
Catabolism in Escherichia coli Publications with downloadable files and supplementary information The
Theoretical & Computational Biology Group at the MRC LMB |
Structural
Studies Division |
