The Constraints Protein-Protein Interactions Place on Sequence Divergence

Sarah A. Teichmann

sat@mrc-lmb.cam.ac.uk

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.


Tab-delimited table of each Saccharomyces cerevisiae sequence, its sequence identity to the matching Schizosaccharomyces pombe protein, and whether the protein is in a stable complex or transient interaction. 1 means yes for each attribute, 0 means no.

Stable complexes are in the Comprehensive Yeast Genome Database (CYGD) catalogue of complexes.

The proteins in this list were excluded from the stable complexes, because they did not qualify as such upon manual inspection.

Proteins in transient interactions are either identified in complexes by mass spectrometry1,2, or in the

CYGD physical interaction table, excluding yeast-two-hybrid experiments.

Table with different names of S. cerevisiae proteins.


References

1. Gavin, A.C. et al. (2002) Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature, 415, 141-7.

2. Ho, Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature, 415, 180-3.