Comparison of the Small Molecule Metabolic Pathways and Enzymes of Escherichia coli and Saccharomyces cerevisiae

Oliver Jardine¹, Julian Gough, Cyrus Chothia and Sarah A. Teichmann²*

¹Department of Crystallography, Birkbeck College, Malet Street, London WC1E 7HX, UK
email: o.jardine@mail.cryst.bbk.ac.uk

²Department of Biochemistry and Molecular Biology, University College London,
Darwin Building, Gower Street, London, WC1E 6BT, UK
email: sat@mrc-lmb.cam.ac.uk

*To whom correspondance should be addressed.
Current address: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK

Supplementary Information

A number of public data sources were used in this project. The table below gives the types of data used and the links to the respective internet sites.

Data	Source	Reference
Annotated genomes	NCBI-Genbank	Benson et al. (2000)
Pathways	KEGG	Kanehisa & Goto (2000)
Additional pathway information	MetaCyc WIT	Karp et al. (2000) Overbeek et al. (2000)
EC numbers	ENZYME	Bairoch (2000)
Protein-protein interactions	MIPS	Mewes et al. (2000)

The links below provide access to the actual lists of data used in the project, as well as the results.

1. Pathway names and numbers

2. Pathway lists

3. Domain assignments

4. EC numbers

5. Consecutive enzymes

6. Cases of non-orthologous displacement

7. Cases of gene fusion

8. Common enzymes and domain similarities