Lineage

Root
1. Class Alpha and beta proteins (a/b) [51349] (51349)
2. Fold Thiamin diphosphate-binding fold (THDP-binding) (52517)

3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

3. Superfamily Thiamin diphosphate-binding fold (THDP-binding) (52518)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
Superfamily

Family

Pyruvate oxidase and decarboxylase PP module (88749)

the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology

Protein Children