Fold Children

• Toxins' membrane translocation domains (56836)

  multi-helical domains of various folds which is thought to unfold in the membrane

• MgtE membrane domain-like (999903)

  5 transmembrane helices; bundle, right-handed twist

• Cation efflux protein transmembrane domain-like (999897)
• ATP synthase B chain-like (999891)

  long single helix, part of the stator subcomplex

• MAPEG domain-like (999885)

  4 helices, bundle; left-handed superhelix

• ATP synthase D chain-like (999873)

  non-globular, mostly helical component of the stator subcomplex

• Photosystem II antenna protein-like (999867)

  6 transmembrane helices arranged in three antiparallel pairs (hairpins), segregated by cofactors; there can be insertions of different small subdomains in different exposed loops

• SNF-like (999858)

  12 transmembrane helices; duplication: consists of two structurally similar halves

• MetI-like (999852)

  core: 5 transmembrane helices; flattened bundle

• Proton glutamate symport protein (118214)

  multihelical membrane protein; partial structural duplication in the C-terminal region; oligomeric state: trimer

• Connexin43 (118219)

  mostly unstructured; 2 helices, hairpin

• Family A G protein-coupled receptor-like (81322)

  core: up-and-down bundle of seven transmembrane helices tilted 20 degrees with respect to the plane of the membrane

• Single transmembrane helix (81407)

  not a true fold

• Bacterial photosystem II reaction centre, L and M subunits (81484)

  five transmembrane helices forming a sheet-like structure

• Cytochrome c oxidase subunit I-like (81443)

  12 transmembrane helices in an approximate threefold rotational symmetric arrangement

• Cytochrome c oxidase subunit III-like (81453)

  core: 7 transmembrane helices organized into two bundles, one formed by the first two helices and the other by the rest

• Transmembrane helix hairpin (81334)

  two antiparallel transmembrane helices

• F1F0 ATP synthase subunit A (81337)

  core: up-and-down bundle of four transmembrane helices

• Aquaporin-like (81339)

  core: 8 helices, 2 short helices are surrounded by 6 long transmembrane helices

• Ammonium transporter (111351)

  11 transmembrane helices; duplication: consist of 2 structural repeats of five helices each plus extra C-terminal helix

• MFS general substrate transporter (103472)

  12 transmembrane helices; duplication: the N- and C-terminal halves are structurally similar

• Clc chloride channel (81341)

  core: 18 transmembrane helices

• Voltage-gated potassium channels (81325)

  oligomeric transmembrane alpha-helical proteins

• Small-conductance potassium channel (81328)

  oligomeric transmembrane alpha-helical protein

• Gated mechanosensitive channel (81331)

  oligomeric transmembrane alpha-helical protein

• Neurotransmitter-gated ion-channel transmembrane pore (90111)

  heteropentameric transmembrane alpha-helical protein; 4 transmembrane helices per subunit

• Mechanosensitive channel protein MscS (YggB), transmembrane region (82860)

  oligomeric fold; 3 transmembrane helices per subunit

• Multidrug resistance efflux transporter EmrE (103480)

  oligomeric fold; 3 transmembrane helices per subunit

• V-type ATP synthase subunit C (103485)

  9 transmembrane helices

• Preprotein translocase SecY subunit (103490)

  10 transmembrane helices forming of a gated channel

• Photosystem I subunits PsaA/PsaB (81559)

  core:11 transmembrane helices

• Photosystem I reaction center subunit X, PsaK (81564)

  core: hairpin of two transmembrane helices

• Photosystem I reaction center subunit XI, PsaL (81569)

  core: three transmembrane helices, bundle

• ABC transporter involved in vitamin B12 uptake, BtuC (81346)

  multihelical; complex architecture with several transmembrane helices

• ABC transporter transmembrane region (90122)

  multihelical; complex architecture with several transmembrane helices

• Multidrug efflux transporter AcrB transmembrane domain (82865)

  12 transmembrane helices; duplication: the N- and C-terminal halves of the whole proteins are structurally similar

• a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (81649)

  core: three transmembrane helices, up-and-down bundle

• Heme-binding four-helical bundle (81344)

  core: four transmembrane helices, up-and-down bundle, binds one or two heme groups in between the helices

• 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (81525)

  membrane-associated alpha-helical protein; no transmembrane helices

• Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (81532)

  membrane-associated alpha-helical protein; no transmembrane helices

• Mitochondrial ATP synthase coupling factor 6 (111356)

  2 helices, hairpin

• Calcium ATPase, transmembrane domain M (81666)

  core: multihelical; consists of three transmembrane regions of 2, 2 and 6 helices, separated by cytoplasmic domains

• Light-harvesting complex subunits (56917)

  membrane all-alpha fold

• Mitochondrial carrier (103505)

  membrane all-alpha fold; 6-helical "barrel" with internal binding cavity

• Chlorophyll a-b binding protein (103510)

  membrane all-alpha fold; three transmembrane helices

• Rhomboid-like (144090)

  6 transmembrane helices

• Transmembrane beta-barrels (56924)

  not a true fold, gathers together transmembrane barrels of different (n,S)

• Outer membrane efflux proteins (OEP) (56953)

  subunit fold contains tandem repeat of alpha-beta hairpin-alpha(2) motif
  trimeric fold contains barrel (n=12, S=18) formed by beta-hairpins, two from each subunit, and a bundle of helices with a channel running through it

• HlyD-like secretion proteins (111368)

  consists of three domains: beta-barrel (res. 29-38,170-259; scop_cf 50412); barrel-sandwich hybrid (39-72,135-169; scop_sf 51230) and long alpha-hairpin (73-134; scop_cf 46556)

• Leukocidin-like (56958)

  subunit fold contains beta-sandwich of Ig-like (grerk-key) topology and a beta-ribbon arm that forms an oligomeric transmembrane barrel

• Lipovitellin-phosvitin complex; beta-sheet shell regions (56967)

  contains several large open beta-sheets

• Aerolisin/ETX pore-forming domain (56972)

  3 domains: (1) alpha+beta; (2&3) all-beta

• Perfringolysin (56977)

  2 domains: (1) alpha+beta; (2) all-beta, similar to the CalB domain fold but the two last strands are transposed

• Viral glycoprotein, central and dimerisation domains (56982)

  2 intertwined domains; all-beta and alpha+beta

• VP4 membrane interaction domain (111378)

  2 domains; d1: complexed all-beta fold; d2: coiled-coil (trimeric) helical region

• Head and neck region of the ectodomain of NDV fusion glycoprotein (69921)

  3 intertwined all-beta domains

• OmpH-like (111383)

  trimer; one subunit consists of an alpha/beta oligomerization subdomain [3-stranded parallel beta-sheet, order 213], and an antiparallel coiled coil

• Anthrax protective antigen (56987)

  4 domains; I (res. 14-225) and II (226-487) are beta-sandwiches of similar gamma-crystallin like topologies; III (488-594) has a beta-grasp like fold; IV (595-735) has an Ig-like fold