- Microbial ribonucleases (53932)
single helix packs against antiparallel beta-sheet
- SARS Nsp1-like (999406)
complex alpha+beta fold; contains mixed beta-sheet barrel, n=6, S=10
- SP0830-like (999400)
duplication: two beta-alpha-beta(2)-alpha-beta-alpha motifs are organized in ferredoxin-like subdomains swapped with the extra C-terminal helices
- YegP-like (999394)
comprises two subunits or tandem repeats of beta(3)-alpha-beta motifs; these assemble with the formation of a single beta-sheet and swapping of the C-terminal strands
- RplX-like (999377)
beta(2)-alpha-beta-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order: 213; some structural similarity to the PurS subunit/repeat (scop_cf 109622)
- NMB0513-like (999371)
alpha(3)-beta(2)-alpha-beta(2); some similarity to the "winged helix" DNA-binding domain fold
- NRDP1 C-terminal domain-like (999365)
alpha-beta-alpha(3)-beta(3); a pseudo barrel beta-sheet of an SH3-like topology, surrounded by helices
- NE1680-like (999358)
beta(2)-alpha-beta-alpha-beta; 2 layers, a/b; antiparallel sheet, order 3124
- PH1570-like (999352)
duplication: two beta(4)-alpha structural repeats, related by pseudo twofold symmetry; two extra helices in the linker region; single 8-standed antiparallel beta-sheet, order: 12348765
- MM3350-like (999346)
beta(2)-alpha-beta(4); antiparallel beta-sheet; order: 216534; similar to a ubiquitin-like fold with the extra C-terminal strand inserted in the middle of the beta-sheet
- PSTPO5379-like (999340)
complex fold; consists of two alpha+beta subdomains, one is inserted in the other
- FlaG-like (999334)
alpha(2)-beta(3)-alpha; 2 layers: a/b; antiparallel beta-sheet, order: 123; partial similatity to the dsRBD-like fold(sop_cf 54767)
- AMPKBI-like (999328)
comprises 3 short helices and 3-stranded meander beta-sheet; makes extensive intermolecular interactions
- SpoVG-like (999316)
beta(5)-alpha; comprises a coiled antiparallel beta-sheet (order: 12345) packed against the C-terminal helix; the extensions of strands 4 and 5 form an isolated beta-hairpin
- PG1857-like (999307)
alpha-beta-alpha-beta(2)-alpha(3); 3 layers, a/b/a; antiparallel beta-sheet, order: 132
- PB2 C-terminal domain-like (999301)
alpha-beta-alpha-X-alpha-beta(2); 3 layers, a/b/a; antiparallel beta-sheet, order 132; connection between helices 2 and 3 runs over the edge of the beta-sheet
- gpW/gp25-like (999295)
alpha(2)-beta(3); similar to one structural repeat of the Creatinase/aminopeptidase family and the C-terminal subdomain of PanC
- PA1123-like (999289)
irregular array of short helices and two three-stranded beta-sheets
- TTHC002-like (999283)
alpha-beta-alpha-beta(3); forms dimer with a single beta-sheet, folded in a barrel-like shape
- SMI1/KNR4-like (999277)
alpha(4)-beta(4)-alpha; 3 layers: a/b/a; antiparallel beta-sheet, order 1234(meander)
- Rv2827c C-terminal domain-like (999265)
multihelical array flanked by two three-stranded mixed beta-sheets
- Phosphoprotein oligomerization domain-like (999259)
intertwinned homodimer of beta(2)-alpha-beta(2) motifs; 3 layers: b/a/b; each antiparallel beta-sheet is formed by the N-terminal beta-hairpin of one subunit and the C-terminal beta-hairpin of the other subunit; order 1243
- BTG domain-like (999253)
alpha(2)-beta-alpha(2)-beta(3); four-helical bundle, capped at one end by a antiparallel beta-sheet, order:1234
- YqaI-like (999243)
dimeric zinc-less 'zinc finger'-like fold; similar to the C-terminal strand-swapped B-box domain (scop_cf 57844)
- Shew3726-like (999237)
beta(3)-alpha(n)-beta; 2 layers, a/b; mixed beta-sheet, order 1234, strands 3 and 4 are parallel with a left-handed crossover connection
- Acetoacetate decarboxylase-like (999231)
complex fold: contains a 3-layer beta-sheet structure, which is folded in two conjoint barrels capped by helices; one rounded barrel has 7 strands, the other flattened barrel has 9 strands
- NMB0488-like (999223)
duplication: two beta(3)-alpha motifs are related by pseudo twofold symmetry; single antiparrallel beta-sheet, order:321456, shaped into a half-barrel; helical linker region
- Taf5 N-terminal domain-like (999217)
multihelical cluster with a C-terminal beta-alpha(2)-beta motif; one central buried helix; parallel beta-ribbon
- Jann2411-like (999207)
unusual fold; consists of seven alpha-helices and three beta-hairpins
- BH3703-like (999201)
alpha-beta(3)-alpha-beta(2)-alpha(2); antiparallel beta-sheet, order:32145; duplication: two alpha-beta(2) structural repeats are arranged with pseudo twofold symmetry
- Lp2179-like (999195)
beta(2)-alpha-beta(4)-alpha-beta; contains two antiparallel beta-sheets (orders: 127 and 3456) packed against the longer C-terminal helix
- PG1388-like (999189)
consists of 2 alpha+beta subdomains, each having a meander beta-sheet; d1: alpha(2)-beta(7); d2: alpha(2)-beta(2)-alpha(2)-beta(2)
- YdfO-like (999183)
duplication: two alpha(2)-beta(3) motifs are related by pseudo twofold symmetry; single antiparrallel beta-sheet, order:321456
- ycgL-like (999177)
beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel beta-sheet, order:3124
- NosL/MerB-like (999171)
unusual fold; comprises two structural repeats of beta(2)-alpha-beta motifs, forming separate beta-sheets; probable duplication
- GINS/PriA/YqbF domain (999161)
beta(4)-alpha-beta; 3-stranded antiparallel beta-sheet (strands 4,1 and 5) are covered on the same side by the helix and beta hairpin of strands 2 and 3; similarity to the L9 N-domain-like fold (scop_cf 55657) and the PsaD fold (scop_sf 64243)
- ATP12-like (999140)
contains an N-terminal beta-sheet that forms a beta-triangle structure; the remainder is a multihelical array of long and short helices
- CPE0013-like (999130)
beta(2)-alpha-beta(3); mixed, mostly antiparallel beta-sheet, folded in a half-barrel; order:31254; strand 3 is parallel to strand 1 and is shorter than the rest
- YehR-like (999124)
beta(3)-alpha-beta(2)-alpha(3)-beta; 2 layers, a/b; antiparallel beta-sheet, order: 612354
- Ava3019-like (999118)
alpha(2)-beta-alpha-beta(4); 2 layers, a/b; antiparallel beta-sheet, order: 32145; similarity to the insert domain of Glucose 6-phosphate dehydrogenase-like family (sop_fa 55376)
- BLRF2-like (999112)
homodimer of alpha(2)-beta motif; also includes extra N-terminal helix of variable position
- EscU C-terminal domain-like (999106)
alpha-beta(3)-alpha-beta-alpha(2); 3 layers, a/b/a; mixed beta-sheet, order: 4123, strand 2 is antiparallel to the rest
- YonK-like (999089)
intertwined dimer of beta(3)-alpha-beta subunits; assembles further in octamer with formation of a wide 16-stranded beta-barrel
- Lysozyme-like (53954)
common alpha+beta motif for the active site region
- Cysteine proteinases (54000)
consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
- His-Me finger endonucleases (54059)
core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures
- RNase A-like (54075)
contains long curved beta-sheet and 3 helices
- EndoU-like (142876)
comprises several helices and two three-stranded antiparallel beta-sheets; similar architecture to the RNase A-like fold (scop_cf 54075)
- Prion-like (54097)
beta-alpha-beta-alpha(2); antiparallel beta-ribbon
- LysM domain (54105)
beta-alpha(2)-beta; antiparallel strands
- gpW/XkdW-like (64209)
alpha-beta(2)-alpha; antiparallel hairpin
- Hypothetical protein MTH677 (110782)
alpha-beta(2)-alpha; 2 layers a/b; antiparallel beta-hairpin
- GTF2I-like repeat (117772)
alpha(2)-beta-alpha-beta-alpha; 2 layers: a/b; antiparallel beta-ribbon
- Urease, gamma-subunit (54110)
alpha(3)-beta(2); antiparallel hairpin
- IL8-like (54116)
beta(3)-alpha
- DNA-binding domain (54170)
beta(3)-alpha; 2 layers: alpha/beta
- Penicillin-binding protein 2x (pbp-2x), c-terminal domain (54183)
alpha1-beta3; 2 layers: alpha/beta; order 132
- Dodecin subunit-like (88797)
beta-alpha-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 132
- Ribosomal proteins S24e, L23 and L15e (54188)
beta-(alpha)-beta-alpha-beta(2); 3 layers: alpha/beta/alpha; antiparallel beta-sheet: order 1243
- Ribosome binding domain-like (100965)
beta-(2)-alpha(2)-beta(2); 2 layers: beta/alpha; antiparallel beta-sheet: order 1243; topological similarity to the common core of ribosomal proteins L23 and L15e
- TFB5-like (142896)
beta-alpha-beta(2)-alpha; 2 layers, a/b; antiparallel sheet, order: 132; dimerises in solution (PDB 2jnj) via extended N-terminal strand
- Obg GTP-binding protein C-terminal domain (102740)
beta-(2)-alpha(3)-beta(2); 2 layers: beta/alpha; mixed beta-sheet: order 1234; strands 2 and 3 a parallel to each other
- HIT-like (54196)
alpha-beta(3)-alpha-beta(2); 3 layers: alpha/beta/alpha
- Secretion chaperone-like (69634)
alpha-beta(3)-alpha-beta(2)-alpha; 2 layers: alpha/beta
- DNA-binding domain of intron-encoded endonucleases (64495)
beta(2)-alpha(2)-beta; 2 layers; 3-stranded antiparallel beta-sheet, order 213; HTH motif; also includes the extra N-terminal, DNA minor groove-binding helix
- MotA C-terminal domain-like (69651)
alpha-beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta
- YktB/PF0168-like (142912)
alpha-beta(4)-alpha-beta(2)-alpha-beta-alpha; 2 layers, a/b; antiparallel beta-sheet, order: 1234756; half-barrel shape; topological similarity to the MotA C-terminal domain-like fold (scop_cf 69651) and the Secretion chaperone-like fold (scop_cf 69634)
- Mago nashi protein (89816)
beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta; antiparallel beta-sheet, order: 651234
- WGR domain-like (142920)
beta(4)-alpha-X-beta; 2 layers, a/b; antiparallel beta-sheet, order 51234; the beta-hairpin insetrion in strand 1 results in the formation of a beta-triangle structure
- Ribosomal protein S5 domain 2-like (54210)
core: beta(3)-alpha-beta-alpha; 2 layers: alpha/beta; left-handed crossover
- beta-Grasp (ubiquitin-like) (54235)
core: beta(2)-alpha-beta(2); mixed beta-sheet 2143
- WWE domain (117838)
beta(2)-alpha-beta(4); antiparallel folded beta-sheet (half-barrel), order 216543
- FAD-linked reductases, C-terminal domain (54372)
alpha+beta sandwich
- Cystatin-like (54402)
Core: alpha-beta(4); helix packs against coiled antiparallel beta-sheet
- Nuclease A inhibitor (NuiA) (82601)
alpha-beta-alpha-beta-alpha(2)-beta(3); antiparallel beta-sheet; order: 15432
- Colicin D/E5 nuclease domain (102823)
alpha(2)-beta(4)-alpha, 2 layers: alpha/beta, antiparallel beta sheet, meander
- RelE-like (143010)
beta-alpha(2)-beta(4), 2 layers; a/b, antiparallel beta-sheet; order 15432
- Hypothetical protein SAV1430 (110835)
beta(3)-alpha-beta(2)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet, order: 12543
- Ns1 effector domain-like (143020)
beta-X-beta(5)-alpha-beta-alpha; 2 layers: a/b; bifurcated beta-sheet; order 23654[1,7]
- YbaB-like (82606)
core: alpha-beta(3)-alpha, 2 layers:alpha/beta, three-stranded antiparallel beta sheet, strand order 123
- Kinetochore globular domain-like (143025)
core: alpha-beta(3)-alpha; variant: alpha-beta(4)-alpha(2)
- L35p-like (143033)
core: alpha-beta(3)-alpha; 2layers a/b
- Cell division protein ZapA-like (102828)
core: beta(2)-alpha(2), 2 layers: alpha/beta; long C-terminal helix forms dimeric parallel and tetrameric antiparallel coiled coils
- ssDNA-binding transcriptional regulator domain (54446)
helix-swapped dimer of beta(4)-alpha motifs
- Photosystem I subunit PsaD (64233)
beta-BETA(2)-beta-alpha-beta(2); antiparallel sheet: order 2134 packed against helix and BETA-hairpin on the same side; irregular C-terminal tail
- MHC antigen-recognition domain (54451)
dimeric
- UBC-like (54494)
alpha-beta(4)-alpha(3); core: meander beta-sheet plus one helix 2
- SAND domain-like (63762)
core: three short helices packed against a barrel-like beta-sheet; some similarity to the SH3-like fold
- Coronavirus NSP8-like (143075)
core: alpha-beta(2)-alpha-beta(4)-alpha-beta; bifurcated barrel-like beta-sheet
- ParB/Sulfiredoxin (110848)
beta*-alpha-beta(2)-alpha-beta-alpha; mixed beta sheet forms a partly open barrel: (n*=4, S*=8)
- Gamma-glutamyl cyclotransferase-like (110856)
beta-alpha-beta(4)-alpha-beta(2); contains beta-sheet barrel (n=5, S=8)
- BB1717-like (143080)
complex fold with a bifurcated beta-sheet structure surrounded by helices; contains beta-sheet barrel, closed (n=5, S=8)
- AF0104/ALDC/Ptd012-like (117855)
duplication: consists of two similar beta-alpha-beta(4) motifs
- NSFL1 (p97 ATPase) cofactor p47, SEP domain (102847)
beta(3)-alpha(2)-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other
- TTHA1013/TTHA0281-like (143099)
beta(3)-alpha-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other; topological similarity to the SEP domain fold (scop_cf 102847); dimerises via the long C-terminal strand with the formation of a single beta-sheet
- Diaminopimelate epimerase-like (54505)
mixed beta-sheet folds into a barrel (n=8, S=14) around the central helix
- GFP-like (54510)
beta-sheet folds into a barrel (n=11, S=14) around the central helix
- Tubby C-terminal domain-like (54517)
beta-sheet folds into a barrel (n=12, S=12) around the central helix
- Pili subunits (54522)
contains very long N-terminal helix, which end is packed against beta-sheet
- Mitochondrial glycoprotein MAM33-like (54528)
core: beta(7)-alpha(2); N- and C-terminal extensions form a coiled coil subdomain
- NAP-like (143112)
core: central meander 4-stranded beta-sheet (order: 1234) transversed by a C-terminal helix
- Polo-box domain (82614)
beta(6)-alpha; antiparallel beta-sheet, meander
- mRNA decapping enzyme DcpS N-terminal domain (102859)
beta(3)-alpha-beta(3)-alpha; 3 layers a/b/a
- Inhibitor of vertebrate lysozyme, Ivy (89871)
alpha(2)-beta(5)-alpha(2); 3 layers a/b/a; meander beta-sheet
- FKBP-like (54533)
core: beta(2)-alpha-beta(2); antiparallel beta-sheet
- Ribosomal protein S16 (54564)
beta(4)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet, order: 51234
- Ribosomal protein S19 (54569)
alpha-beta-X-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 123
- YefM-like (143119)
core: beta-alpha(2)-beta(2)-alpha; mixed beta-sheet, order:123, strands 1 and 2 are parallel; forms compact dimer with a single beta-sheet;
- Ribosomal protein L31e (54574)
beta-alpha-beta-(alpha)-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 1342
- Allophycocyanin linker chain (domain) (54579)
beta(2)-alpha-beta; 2 layers: alpha/beta
- Cdc48 domain 2-like (54584)
beta-alpha-beta(3); 2 layers: alpha/beta
- Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase (54592)
beta-alpha-beta(3); 2 layers: alpha/beta
- Chromosomal protein MC1 (102874)
beta(2)-alpha-beta(3); 2 layers: alpha/beta
- beta-hairpin-alpha-hairpin repeat (74651)
multiple repeats of beta(2)-alpha(2) motif
- Proguanylin (89889)
beta(2)-alpha(3)-beta; two layers: alpha/beta; antiparallel sheet: order 213
- SecB-like (54610)
beta(4)-alpha(2); two layers: alpha/beta; antiparallel sheet: order 1432
- MesJ substrate recognition domain-like (82828)
beta-alpha(2)-beta(3); 2 layers: a/b; antiparallel beta-sheet, order:1432
- FYSH domain (89894)
beta(2)-alpha(2)-beta(2)-alpha-beta; two layers: alpha/beta; antiparallel sheet: order 51234
- VSV matrix protein (75403)
beta-alpha(2)-beta(4)-alpha-beta(2); two layers: alpha/beta; bifurcated coiled beta-sheet: order of the first 5 strands: 23154
- DNA-binding domain of Mlu1-box binding protein MBP1 (54615)
beta(4)-alpha(2)-beta(2)-alpha; antiparallel sheet: order 123465
- Heme-binding protein A (HasA) (54620)
beta-alpha-beta(6)-alpha(2); antiparallel sheet: order 165432
- Chalcone isomerase (54625)
beta(3)-alpha(2)-beta-alpha(2)-beta3; 2 layers alpha/beta; antiparallel sheet: order 1234567
- Coproporphyrinogen III oxidase (102885)
alpha-beta(6)-alpha(2)-beta-alpha(n); 3 layers alpha/beta/alpha; antiparallel sheet: order 1234567
- Hypothetical protein Ta1206 (102890)
beta(4)-alpha-beta(2)-alpha(2); mixed, predominately antiparallel beta-sheet, order: 123465, strands 4 and 5 are parallel to each other
- CBS-domain (54630)
core: beta-alpha-beta(4); 2 layers: alpha/beta
- Thioesterase/thiol ester dehydrase-isomerase (54636)
core: beta-alpha-beta(4); 2 layers: alpha/beta
- DLC (54647)
core: beta-alpha(2)-beta-X-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 1342
- CI-2 family of serine protease inhibitors (54653)
alpha+beta sandwich; loop across free side of beta-sheet
- Integrin beta tail domain (69686)
alpha-beta-loop-beta(3); loop across free side of beta-sheet
- alpha/beta-Hammerhead (54664)
core: beta-BETA-alpha-beta-BETA-beta-alpha; contains a beta-hammerhead motif similar to that in barrel-sandwich hybrids
- POZ domain (54694)
core: beta(2)-alpha(2)-beta(2)-alpha(2); 2 layers a/b; mixed sheet: 2143
- EF-Ts domain-like (54712)
beta(2)-alpha(n)-beta; 2 layers a/b; antiparallel sheet: 123
- Fe,Mn superoxide dismutase (SOD), C-terminal domain (54718)
alpha-beta(2)-alpha-beta-alpha(2); 3 strands of antiparallel sheet: 213
- ClpS-like (54735)
beta-alpha(2)-beta-alpha-beta; 2 layers, alpha/beta
- Hypothetical protein MTH1880 (75411)
beta-alpha-beta(2)-alpha(2); 3 layers, alpha/beta/alpha; antiparallel beta-sheet: order 123
- Ribosomal L11/L12e N-terminal domain (54746)
beta-alpha(2)-beta(2); 2 layers, alpha/beta; antiparallel beta-sheet: order 123
- Anti-LPS factor/recA domain (54751)
alpha-beta(3)-alpha(2); 2 layers, alpha/beta
- Signal recognition particle alu RNA binding heterodimer, SRP9/14 (54761)
(beta)-alpha-beta(3)-alpha; 2 layers, alpha/beta
- dsRBD-like (54767)
alpha-beta(3)-alpha; 2 layers: alpha/beta
- 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain (110920)
duplication: consists of two beta(3)-alpha repeats; 3 layers, beta/alpha/beta
- SRP19 (69694)
beta-alpha-beta(2)-alpha; 2 layers: alpha/beta
- SufE/NifU (82648)
alpha(2)-beta(3)-alpha(3); 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123
- DNA-binding protein Tfx (89914)
alpha(3)-beta-alpha(2)-beta(2); 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123
- Eukaryotic type KH-domain (KH-domain type I) (54790)
beta-alpha(2)-beta(2)-alpha; 2 layers: alpha/beta
- Alpha-lytic protease prodomain-like (54805)
core: alpha-beta(2)-(alpha)-beta; 2 layers: alpha/beta
- Nucleotidyltransferase (81302)
core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order of core strands: 123
- Nqo5-like (143242)
core: alpha-beta(2)-alpha-beta(3); 2 layers, a/b; mixed beta-sheet, order 12534, strands 2 and 5 are parallel
- Ribosomal protein S3 C-terminal domain (54820)
alpha(2)-beta(4); 2 layers: alpha/beta; antiparallel beta-sheet: order 2143
- Transcription factor NusA, N-terminal domain (69704)
alpha-beta(3)-alpha-beta-alpha; bifurcated coiled beta-sheet
- Enolase N-terminal domain-like (54825)
beta(3)-alpha(3); meander and up-and-down bundle
- Ribosomal protein L22 (54842)
beta-alpha(3)-beta(2); 2 layers: alpha/beta; related to the enolase/MLE N-domain fold by a circular permutation
- Prokaryotic ribosomal protein L17 (64262)
alpha-beta-alpha(3)-beta(2); 2 layers: alpha/beta;
- GroEL-intermediate domain like (54848)
3-helical bundle packed against 3-stranded mixed beta-sheet
- PX domain (64267)
beta(3)-alpha(4); meander beta-sheet packed against array of helices; contains Pro-rich stretch
- DsrC, the gamma subunit of dissimilatory sulfite reductase (69720)
beta(3)-alpha(5); meander beta-sheet packed against array of helices
- DNA damage-inducible protein DinI (54856)
beta-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed sheet 213; crossing loops
- HSP90 C-terminal domain (110941)
alpha-beta(3)-alpha(3); 2 layers, a/b; mixed beta-sheet, order:132; crossing loops
- Ferredoxin-like (54861)
alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2
- PurS-like (109622)
consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold
- Dystroglycan, domain 2 (111005)
beta-alpha-beta-X-beta(2)-alpha(2)-beta; antiparallel beta-sheet, order 24153; topological similarity to the ferredoxin-like fold (scop_cf 54861)
- Pseudouridine synthase (100877)
consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold
- Folate-binding domain (103024)
duplication: consists of two beta(2)-alpha-beta(3)-alpha subdomains swapped with the first strands
- THUMP domain (143436)
contains mixed 8-stranded beta-sheet, folded into a half-barrel and covered with 4 helices on the outside; order 32148756; strands 5, 6 and 7 are parallel
- AMMECR1-like (143446)
duplication; contains two beta(2)-alpha-beta(2) structural repeats, swapped with C-terminal strands; extra N-terminal helix and C-terminal strand
- YehU-like (118000)
beta-alpha(2)-beta(2)-alpha; 3 layers, alpha/beta/alpha; antiparallel beta-sheet: order 123
- Hypothetical protein YwqG (103031)
duplication: contains two similar beta-x-beta(4) motifs swapped with the first strands
- VC0467-like (143455)
complex fold; contains bifurcated beta-sheet structure folded into pseudo barrel
- Lesion bypass DNA polymerase (Y-family), little finger domain (100878)
beta-alpha-beta(2)-alpha-beta; antiparallel beta-sheet: order 1423; "reversed" ferredoxin-like topology
- ImmE5-like (143468)
alpha-beta(2)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order 213
- Ribosomal protein L30p/L7e (55128)
core: beta-alpha-beta-alpha-beta; antiparallel beta-sheet: order 312; some similarity to the ferredoxin-like fold
- Chorismate lyase-like (64287)
duplication of alpha(2)-beta(3) motif; antiparallel beta sheet, order 123654
- TM1622-like (143476)
alpha-beta(3)-alpha-beta(4)-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order: 1237654
- Probable bacterial effector-binding domain (55135)
duplication of beta-alpha-beta(2) motif: antiparallel beta sheet forms barrel (n=6, S=12)
- CheC-like (103038)
duplication: tandem repeat of two intertwined alpha-beta-(X)-beta(2) motifs
- LigT-like (55143)
duplication of beta-alpha-beta-alpha-beta motif: antiparallel beta sheet forms barrel (n=6, S=8) similar to the barrel of prokaryotic DNA topoisomerases I and III
- Pepsin inhibitor-3 (55148)
duplication of beta(3)-alpha(2) motif: meander beta sheets form barrel-like structure
- CYTH-like phosphatases (55153)
duplication of beta-alpha-beta(3) motif: antiparallel beta sheet forms wide barrel (n=8, S=16) with a channel running through it
- Antiparallel beta/alpha barrel (PT-barrel) (143491)
tandem repeat of five alpha(2)-beta(2) motifs; antiparallel beta-sheet barrel, closed; n=10, S=10; order 123456789A; there is a channel along the barrel axis
- eIF1-like (55158)
beta(2)-alpha-beta(2)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet: order 51243
- Hedgehog/DD-peptidase (55165)
alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta
- Alpha-L RNA-binding motif (55173)
alpha(2)-beta(2)-loop-beta; 2 layers: alpha/beta
- RRF/tRNA synthetase additional domain-like (55185)
core: alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta
- LuxS/MPP-like metallohydrolase (63410)
core: beta-alpha-beta(2)-alpha(2); 2 layers: alpha/beta
- IF3-like (55199)
beta-alpha-beta-alpha-beta(2); 2 layers; mixed sheet 1243, strand 4 is antiparallel to the rest
- PUG domain-like (143502)
alpha(2)-beta-alpha(2)-beta(2)-alpha; cluster of helices with a small antiparallel beta-sheet on one side; order 132; topological similarity to the fold of an extended R3H domain (PDB 1whr)
- Ribosome binding protein Y (YfiA homologue) (69753)
beta-alpha-beta(3)-alpha; 2 layers; mixed sheet 1234, strand 3 is antiparallel to the rest
- TolA/TonB C-terminal domain (74652)
beta(2)-alpha-beta; 2 layers, alpha/beta; left-handed beta-alpha-beta unit in non-swapped monomer
- Yeast killer toxins (55220)
beta-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta; left-handed crossover connection
- Cell division protein MinE topological specificity domain (55228)
dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta
- Hypothetical protein YoaG (103062)
dimer of beta(2)-alpha motifs ; 2 layers, alpha/beta; reverse MinE topology
- Nucleocapsid protein dimerization domain (103067)
dimer of alpha-beta(2)-alpha motifs ; 2 layers, alpha/beta
- Cyanase C-terminal domain (55233)
intertwined dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta
- Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains (82713)
Intertwined pseudo hexamer of an alpha+beta motif
- RuBisCO, small subunit (55238)
alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta
- DCoH-like (55247)
beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
- TRCF domain-like (143516)
beta-alpha(3)-beta(2)-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed beta sheet, order 12354, strands 1 and 2 are parallel; some topological similarity to the DCoH-like fold (scop_cf 55247)
- Hypothetical protein Yml108w (100886)
beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta; mixed beta-sheet 2143, strands 1 and 4 are parallel
- MutS N-terminal domain-like (55266)
beta(2)-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta
- GYF/BRK domain-like (55276)
beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
- GTP cyclohydrolase I feedback regulatory protein, GFRP (69760)
beta(2)-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta, antiparallel beta-sheet: order 342165
- RL5-like (55281)
beta-alpha-beta(2)-alpha-beta(3)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet: order 231654
- RPB5-like RNA polymerase subunit (55286)
core: beta-alpha-beta-alpha-beta(2); 2 layers, alpha/beta
- Bacillus chorismate mutase-like (55297)
core: beta-alpha-beta-alpha-beta(2); mixed beta-sheet: order: 1423, strand 4 is antiparallel to the rest
- YjbQ-like (111037)
beta(2)-alpha-beta(2)-alpha(2)-beta(3); contains a beta-sandwich: 7 strands in 2 sheets; trimerizes with orthogonally packed beta-sheets
- Tautomerase/MIF (55330)
(beta-alpha-beta)2; 2 layers: alpha/beta; mixed beta-sheet
generally forms trimers with three closely packed beta-sheets
- FwdE/GAPDH domain-like (55346)
core: alpha-beta-alpha-beta(3); mixed sheet: 2134, strand 2 is parallel to strand 1
- Hypothetical protein PF0899 (111056)
alpha-beta-alpha-beta(4); 2 layers: a/b; mixed beta-sheet, order 23145, strands 1 and 3 are parallel; similar to the GAPDH C-terminal domain-like fold (scop_cf 55346)
- Major capsid protein gp5 (56562)
unusual fold; contains PF0899-like core, decorated with additional structure
- MK0786-like (143559)
alpha(2)-beta(4); 2 layers: a/b; antiparallel beta-sheet, order 1234 (meander)
- YkuJ-like (143566)
alpha-beta(4)-alpha; 2 layers a/b; antiparallel beta-sheet, order 1234
- N domain of copper amine oxidase-like (55382)
alpha-beta(5)-alpha; 2 layers: alpha/beta; meander antiparallel sheet
- Aha1/BPI domain-like (55393)
core: [beta]-alpha-beta(5)-alpha; 2 layers: alpha/beta; antiparallel beta-sheet, meander
- Subtilisin inhibitor (55398)
alpha+beta sandwich
- RNA bacteriophage capsid protein (55404)
6-standed beta-sheet followed with 2 helices; meander
- eIF4e-like (55417)
beta(2)-alpha-beta(2)-alpha-beta(2)-alpha-beta-2; 2 layers: alpha/beta; antiparallel sheet: 21356478
- CO dehydrogenase flavoprotein C-domain-like (55423)
core: beta(3,4)-alpha(3); alpha+beta sandwich
- SRF-like (55454)
alpha-beta(2)-alpha; dimer; 3 layers a/b/a; antiparallel beta-sheet
- Origin of replication-binding domain, RBD-like (55463)
alpha-beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel sheet 41325
- SARS receptor-binding domain-like (143586)
core: 3 layers, a/b/a; antiparallel beta-sheet of 5 strands, order 13542
- Hut operon positive regulatory protein HutP (111063)
alpha(2)-beta-alpha(2)-beta(3); 3 layers: a/b/a; antiparallel beta-sheet: order 1234
- Hypothetical protein yfbM (111068)
beta-alpha(2)-beta-alpha(2)-beta(2)-alpha(n)-beta; 3 layers: a/b/a; antiparallel beta-sheet, order: 21543
- TTHA1528-like (143591)
beta-alpha-beta(3)-alpha-beta-alpha(2)-beta; 3 layers: a/b/a; mixed beta-sheet, order: 143256, parallel strands' pairs are 1-4 and 2-5
- YojJ-like (143596)
alpha-beta-X-beta-alpha-beta(2)-alpha-beta(3); 3 layers: a/b/a; 7-stranded mixed beta-sheet, order 2431567; strands 1 and 3 are parallel to each other
- STIV B116-like (143601)
subunit fold consists of mixed 5-stranded beta-sheet, order:31452, strand 5 is antiparallel to the rest, with 3 helices on one side; dimerises with the formation of a single 10-stranded beta-sheet; strand 2 is in the dimer interface
- Bacillus phage protein (111073)
alpa-beta(3)-alpha-beta(3)-alpha; 3 layers: b/a/b, 3-helical bundle flanked by two 3-stranded meander beta-sheets
- FMN-dependent nitroreductase-like (55468)
core: (alpha-beta-alpha-beta)2; 3 layers a/b/a; antiparallel beta-sheet: 1243
- N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 (55480)
alpha-beta-alpha(2)-beta(3)-alpha; 3 layers a/b/a; antiparallel beta-sheet: 4123
- Zincin-like (55485)
contains mixed beta sheet with connection over free side of the sheet
- SH2-like (55549)
3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices
- HPr-like (55593)
beta-alpha-beta(2)-alpha-beta-alpha; 2 layers: a/b; antiparallel sheet 1423
- TrkA C-terminal domain-like (116725)
beta-X-beta(2)-X-beta-alpha; pseudo barrel capped by helix at one end; topological similarity to the HPr-like fold
- Hypothetical protein YjiA, C-terminal domain (90001)
beta-alpha-beta(4)-alpha; 2 layers: a/b; antiparallel sheet 15234; topological similarity to the HPr-like fold
- YggU-like (69785)
beta(2)-loop-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243; some similarity to the Homing endonuclease-like fold
- Homing endonuclease-like (55603)
alpha-beta(2)-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243
- T-fold (55619)
beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
tunnel-shaped: its known members form wide oligomeric barrels different sizes
- Cell cycle regulatory proteins (55636)
beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1243
can form strand-exchange dimers
- BLIP-like (55647)
alpha(2)-beta(4); 2 layers: alpha/beta
- Ribosomal protein L9 C-domain (55652)
alpha-beta-alpha(2)-beta(2); 2 layers: alpha/beta
- MbtH/L9 domain-like (55657)
beta(2)-alpha-beta-alpha; 3 layers: alpha/beta/alpha
- Tombusvirus P19 core protein, VP19 (103144)
beta(2)-alpha-beta(2)-alpha; 2 layers: alpha/beta; antiparallel sheet: order 2134
- Ribonuclease PH domain 2-like (55665)
beta(2)-alpha-beta(2)-alpha; 3 layers: alpha/beta/alpha; antiparallel sheet: order 2134
- Regulatory factor Nef (55670)
alpha(2)-beta(4)-alpha; 3 layers: alpha/beta/alpha
- CytB endotoxin-like (55675)
core: beta-alpha(2)-beta-alpha(2)-beta(4); 3 layers: a/b/a
- Class II aaRS and biotin synthetases (55680)
contains large mixed beta-sheet
- Subdomain of clathrin and coatomer appendage domain (55710)
beta-alpha-beta-alpha-beta(4)-alpha; 3 layers: a/b/a; bifurcated antiparallel beta-sheet
- SCP-like (55717)
alpha-beta(3)-(crossover)-beta-(alpha)-beta; 3 layers: a/b/a; antiparallel beta-sheet of 5 strands; order: 32145
- Ta1353-like (103164)
core: beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel beta-sheet of 5 strands; order: 51423;
- Mog1p/PsbP-like (55723)
(beta-hairpin)-beta(3)-alpha-beta(4)-alpha; 3 layers: a/b/a; antiparallel beta-sheet of 7 strands; order: 1237654
- Acyl-CoA N-acyltransferases (Nat) (55728)
3 layers: a/b/a; contains mixed beta-sheet
- Gelsolin-like (55752)
3 layers: a/b/a; contains mixed beta-sheet
- PHP14-like (143723)
beta(3)-alpha-beta(2)-alpha-beta; 3 layers, a/b/a; mixed beta-sheet, half-barrel, order: 132456; strands 2 and 5 are antiparallel to the rest
- Profilin-like (55769)
core: 2 alpha-helices and 5-stranded antiparallel sheet: order 21543; 3 layers: alpha/beta/alpha
- Ligand-binding domain in the NO signalling and Golgi transport (111125)
an N-terminal helical bundle and the C-terminal alpha-beta(2)-alpha-beta(2) subdomain enclose a ligand-binding cavity
- Phage tail protein-like (143748)
alpha-beta-X-beta(2)-alpha-beta(2); 2 layers: a/b; mixed beta-sheet: order 12354, strands 1 and 2 are parallel
- PR-1-like (55796)
alpha-beta-alpha-beta-alpha(2)-beta(2); 3 layers, alpha/beta/alpha; mixed sheet: order 1342
- Phoshotransferase/anion transport protein (55803)
beta-alpha(2)-beta(3)-alpha(3); 3 layers, alpha/beta/alpha; mixed sheet: order 1342; loop crossing
- Nudix (55810)
beta(2)-alpha-beta(3)-alpha; 3 layers: alpha/beta/alpha; mixed sheet
contains beta-grasp motif
- 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain (55815)
core: alpha-beta(2)-alpha-beta(2)-alpha-beta; 3 layers; mixed sheet: order 31425
- YrdC/RibB (55820)
core: alpha-beta(2)-alpha-beta-alpha(2)-beta(2)-alpha-beta-alpha-beta; 3 layers; mixed twisted sheet of 7 strands; order 7126354; strands 7 and 1 are parallel to each other
- GIY-YIG endonuclease (82770)
beta(2)-alpha(2)-beta-alpha-(beta); strand 4 is very short; 3 layers; antiparallel (mixed) beta-sheet; order 312(4)
- YbaK/ProRS associated domain (55825)
core: alpha-beta-alpha-beta(2)-(alpha-beta)2-alpha-beta(2)-alpha-beta; 3 layers; bifurcated mixed sheet
- Thymidylate synthase/dCMP hydroxymethylase (55830)
contains large mixed beta-sheet
- Thymidylate synthase-complementing protein Thy1 (69795)
complex alpha+beta fold; contains antiparallel 5-stranded beta-sheet: order 12354
- N-acetylmuramoyl-L-alanine amidase-like (55845)
contains mixed beta-sheet
- Cytochrome b5-like heme/steroid binding domain (55855)
beta-alpha-beta(2)-alpha(1,2)-(beta)-alpha(2)-beta; 3 layers: a/b/a; antiparallel beta-sheet, order: 1532(4)
- DUSP-like (143790)
alpha-beta-alpha-X-beta-alpha-beta; three-helical bundle capped at one end by antiparallel beta-sheet, order: 213
- DNA topoisomerase I domain (55868)
beta(2)-alpha-beta-(alpha)-beta(2); left-handed crossover between strands 2 & 3
- ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (55873)
8-stranded mixed beta-sheet; 2 layers: alpha/beta
- Sporulation response regulatory protein Spo0B (55889)
core: alpha-beta-alpha-beta(2)-(alpha)-beta(2)
- Ribonuclease Rh-like (55894)
alpha+beta fold
- YlxR-like (64375)
alpha+beta fold; could have evolved from a glucocorticoid receptor-like zinc finger domain
- YggX-like (111147)
beta(2)-alpha(3); contains zinc-less 'zinc finger'-like fold (scop_cf 57715; see also scop_cf 64375)
- L28p-like (143799)
unusual fold consisting of three beta-hairpins, that form a paper clip-like structure, and two helices; could have evolved from a glucocorticoid receptor-like zinc finger domain (scop_cf 57715)
- Ornithine decarboxylase C-terminal domain (55903)
complex alpha+beta motif
- Pentein, beta/alpha-propeller (55908)
duplication: composed of 5 alpha-beta(2)-alpha-beta units arranged around pseudo fivefold axis
- Creatinase/aminopeptidase (55919)
duplication: composed of two very similar alpha+beta folds
- Glutamine synthetase/guanido kinase (55930)
duplication: common core consists of two beta-alpha-beta2-alpha repeats
- TBP-like (55944)
beta-alpha-beta(4)-alpha
- XisI-like (143846)
alpha-beta(4)-alpha-beta-alpha; 2 layers, a/b; antiparallel beta-sheet, order 1234, meander; the open side of beta-sheet provides dimerization interface
- S-adenosylmethionine synthetase (55972)
duplication: consists of 3 similar intertwined domains
structural repeat: beta-alpha-beta(2)-alpha-beta; two layers, alpha/beta
- DNA clamp (55978)
contains two helices and two beta sheets
duplication: fold has internal pseudo two-fold symmetry
- Hypothetical protein TM0160 (103255)
duplication: consists of two beta(3)-alpha(2) structural repeats; single barrel-like beta-sheet
- Molybdenum cofactor-binding domain (56002)
beta(2)-alpha-beta-alpha-beta; 2 layers: a/b; mixed sheet: order 1243: crossing loops
- Nitrite and sulphite reductase 4Fe-4S domain-like (56013)
beta-alpha-beta-alpha-beta(3)-alpha(2,3); mixed sheet: order 12345; left-handed crossover connection between strands 1 and 2
- DeoB insert domain-like (143855)
alpha-beta-X-beta(2)-alpha-beta(2); 2 layers, a/b; mixed beta-sheet of 5 strands, order 12345; strands 2 and 5 are antiparallel to the rest
- The spindle assembly checkpoint protein mad2 (56018)
core: alpha(2)-beta(2)-alpha-beta; mixed sheet: order 213
- Phospholipase D/nuclease (56023)
beta-alpha-beta-alpha-beta-alpha-beta(4)-alpha; mixed sheet: order 1765234
- CorA soluble domain-like (143864)
beta(2)-alpha-beta-alpha(2)-beta(4)-alpha(3); 3 layers: a/b/a; mixed beta-sheet, order 2137654; strands 3 and 7 are parallel
- Monooxygenase (hydroxylase) regulatory protein (56028)
corner-like structure formed by two sheets and filled in with 2-3 helices
- PurM C-terminal domain-like (56041)
3 layers: alpha/beta/alpha; partial topological similarity to the ferredoxin-like fold
- PF0523-like (143869)
beta-alpha-beta-alpha(3)-beta-alpha-beta-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order 4132; some similarity to the PurM C-terminal domain-like fold (scop_cf 56041)
- Chorismate synthase, AroC (103262)
duplication: consists of two DCoH-like beta(2)-alpha-beta(2)-alpha structural repeats; 3 layers, beta/alpha/beta
- Hsp33 domain (64396)
3 layers: beta/alpha/beta; buried helix
- MTH1598-like (69818)
beta(2)-alpha-beta-alpha-beta(4); 3 layers: beta/alpha/beta; some similarity to the Hsp33 fold
- Protein-L-isoaspartyl O-methyltransferase, C-terminal domain (68929)
beta-alpha-beta(4)-alpha-beta(2); 3 layers: beta/alpha/beta; buried helix
- OsmC-like (82783)
swapped dimer of beta(3)-alpha-beta(2)-alpha(2)-beta subunits; mixed beta-sheet; order: 321[4][5][6]; buried helix
- Hypothetical protein HI1480 (103276)
beta-alpha(4)-beta-alpha-beta; segregated alpha-helical and beta-sheet subdomains; dimeric beta-sheet barrel: n=6, S=10
- ERH-like (143874)
beta(2)-alpha(2)-beta(2)-alpha; antiparallel beta-sheet, order:2134; helices are arranged in a bundle rather than packed agains beta-sheet; dimerises via with the formation of a flattened beta-barel: closed n=8, S=10
- Ribosomal protein S8 (56046)
consists of 2 different alpha+beta subdomains arranged in a 4-layer structure: b/a/b/a
- Ribosomal protein L6 (56052)
consists of two beta-sheets and one alpha-helix packed around single core
- NE0471 N-terminal domain-like (143879)
beta(3)-alpha(n)-beta(3)-alpha; the two meander beta-sheets and helices are packed against the same core
- RGC domain-like (143884)
consists of two beta-sheets and four helices eclosing a cental cavity
- Smc hinge domain (75552)
consists of 2 different alpha+beta subdomains; forms subdomain-swapped dimers
- DNA mismatch repair protein MutL (118115)
consists of two different alpha+beta (sub)domains; d1: [beta(3)-alpha-(insert of d2)-alpha(2)-beta; 2 layers, a/b; antiparallel sheet, order: 1234]; d2: [beta-alpha-beta(2)-alpha(2); 2 layers, a/b; antiparallel sheet, order: 132]
- ATP-grasp (56058)
Consists of two subdomains with different alpha+beta folds
shares functional and structural similarities with the PIPK and protein kinase superfamilies
- SAICAR synthase-like (56103)
consists of two alpha+beta subdomains
- Protein kinase-like (PK-like) (56111)
consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
- FAD-binding/transporter-associated domain-like (56175)
consists of two alpha+beta subdomains
- Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain (56193)
consists of two alpha+beta subdomains
- Methenyltetrahydromethanopterin cyclohydrolase (56198)
consists of two alpha+beta subdomains
- Prim-pol domain (56746)
consists of two alpha+beta domains
- Hect, E3 ligase catalytic domain (56203)
consists of two alpha+beta domains; the N-terminal domain is array of helices and beta-hairpins; the C-terminal domain is an a/b sandwich with one left-handed beta-alpha(n)-beta unit; conformational flexibility of domain orientation
- Nitrile hydratase alpha chain (56208)
4 layers a/b/b/a; inside is a sandwich of two 2-stranded beta-sheets
- 4'-phosphopantetheinyl transferase (56213)
beta-alpha(3)-beta(2) motif
- DNase I-like (56218)
contains beta-sandwich; duplication of alpha+beta motif
- Aldehyde ferredoxin oxidoreductase, N-terminal domain (56227)
contains sandwich; duplication of alpha+beta motif with single mixed sheet
motif: beta(2)-alpha-beta(3)-alpha-beta; strand order 216345, strands 1 and 6 are parallel
- Ntn hydrolase-like (56234)
4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
- DmpA/ArgJ-like (56265)
duplication of beta(3)-alpha-beta-alpha motif; 4 layers: alpha/beta/beta/alpha
- Pyruvoyl-dependent histidine and arginine decarboxylases (56270)
duplication of beta-alpha-beta(2) motif; 4 layers: alpha/beta/beta/alpha; contains "silk" beta-sandwich
- S-adenosylmethionine decarboxylase (56275)
duplication of beta-alpha-beta(4)-alpha-beta-alpha-beta(2) motif; 4 layers a/b/b/a; antiparallel beta-sheets: order 23451687
- Metallo-hydrolase/oxidoreductase (56280)
duplication of beta(4)-alpha-beta-alpha motif; 4 layers a/b/b/a; mixed beta-sheets
- PP2C-like (81607)
4 layers: alpha/beta/beta/alpha; antiparallel beta sheets
- Metallo-dependent phosphatases (56299)
4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication
- Carbon-nitrogen hydrolase (56316)
4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication
- CNF1/YfiH-like putative cysteine hydrolases (64437)
4 layers: alpha/beta/beta/alpha; mixed beta sheets
- ADC synthase (56321)
duplication: contains four repeats of alpha-beta(2)-beta motif arranged in a 4 layer core structure: alpha/beta/beta/alpha; orthogonally packed beta-sheets
- Sulfolobus fructose-1,6-bisphosphatase-like (111248)
4 layers: a/b/b/a; antiparallel beta sheets; similarities to ferredoxin-like fold (scop_cf 54861) in the N-terminal part (1-120) and to the Bacterial S-adenosylmethionine decarboxylase subunit (scop_fa 997656) in the C-terminal part (121-340)
- LDH C-terminal domain-like (56326)
unusual fold, defines family
- DNA breaking-rejoining enzymes (56348)
core: alpha3-beta3-alpha4; one side of beta-sheet is exposed
- Replication modulator SeqA, C-terminal DNA-binding domain (82807)
consists of seven alpha-helices and three-stranded beta-sheet
- SMAD MH1 domain (56365)
consists of four alpha-helices and three beta-ribbons
- YopH tyrosine phosphatase N-terminal domain (64448)
consists of four alpha-helices and two beta-hairpins
- Rotavirus NSP2 fragment, N-terminal domain (75573)
consists of six alpha-helices and two beta-hairpins
- Ribosome inactivating proteins (RIP) (56370)
contains mixed beta-sheet
- ADP-ribosylation (56398)
unusual fold
- Peptide deformylase (56419)
alpha-beta(5)-alpha; 3 layers: a/b/a; meander beta-sheet wraps around the C-terminal alpha-helix
- LCCL domain (69847)
unusual fold
- Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (56424)
unusual fold
- C-type lectin-like (56435)
unusual fold
- Hemolytic lectin CEL-III, C-terminal domain (111264)
unusual fold
- SRCR-like (56486)
unusual fold; disulfide-rich; core: beta-x-alpha-beta-loop-beta
- Fibrinogen C-terminal domain-like (56495)
unusual fold
- gp120 core (56501)
unusual fold
- Methionine synthase activation domain-like (56506)
unusual fold; core: beta-alpha(2)-beta(2)-alpha(2)-beta-alpha-beta; antiparallel beta-sheet: order 12354
- UbiD C-terminal domain-like (143967)
alpha-beta(2)-alpha-beta-alpha-beta(2); 3 layers, a/b/a; mixed beta-sheet, order: 12354, strands 2,3 and 5 are parallel to each other
- Hypothetical protein TM0875 (90063)
unusual fold; core: beta(2)-loop-beta(2)-alpha-beta; mixed beta-sheet: order 51243; parallel strands 2 and 4
- Metal cation-transporting ATPase, ATP-binding domain N (81661)
unusual fold; core: beta-alpha(2)-beta(3)-alpha(2)-beta(2); 6-stranded antiparallel beta-sheet, order: 165432
- Suppressor of Fused, N-terminal domain (103358)
unusual fold; bifurcated beta-sheet; left-handed beta-alpha-beta unit
- Nitric oxide (NO) synthase oxygenase domain (56511)
unusual fold
- Penicillin binding protein dimerisation domain (56518)
unusual fold
- Oxidoreductase molybdopterin-binding domain (56523)
unusual fold; contains 3 layers of beta-sheet structure and a beta-grasp like motif
- FAH (56528)
unusual fold; contains 3 layers of beta-sheet structure
- Aromatic aminoacid monoxygenases, catalytic and oligomerization domains (56533)
unusual fold
- Substrate-binding domain of HMG-CoA reductase (56541)
unusual fold
- Argininosuccinate synthetase, C-terminal domain (69863)
unusual fold
- Hypothetical protein PH1602 (103364)
complex alpha+beta fold; contains a region of similarity to the ferredoxin-like fold
- IlvD/EDD N-terminal domain-like (143974)
contains a large cluster of helices and a mixed beta-sheet of 4 strands; order 2134, strands 3 and 4 are parallel
- DNA methylase specificity domain (116733)
comprises the N-terminal, double beta-helix like structure and C-terminal alpha-hairpin
- GCM domain (90072)
consists of two different alpha+beta subdomains; 2 zinc-binding sites
- Conserved core of transcriptional regulatory protein vp16 (56547)
unusual fold
- Insert subdomain of RNA polymerase alpha subunit (56552)
unusual fold; contains a left-handed beta-alpha-beta unit
- Baseplate structural protein gp11 (56557)
unusual fold; trimer
- Receptor-binding domain of short tail fibre protein gp12 (88873)
unusual fold; trimer
- Outer capsid protein sigma 3 (64464)
unusual fold
- Phosphoprotein M1, C-terminal domain (118172)
consists of 6 helices and one beta-hairpin
- L,D-transpeptidase pre-catalytic domain-like (143984)
unusual fold, made of four helices and four 2-3 stranded beta-sheets
- YbiA-like (143989)
consists of six alpha-helices and two two-stranded beta-sheets
- NinB (103369)
unusual fold; intertwined dimer; consists of two different structural domains
- AF2331-like (143994)
interlocked dimer of beta-alpha-beta(2)-alpha-beta-(alpha) subunits; 3 layers: b/b/a
- SSo0622-like (111277)
alpha(2)-beta(2)-alpha-beta-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel beta-sheet: order 21354; strands 1,3 and 5 and the C-terminal helix are longer than other secondary structures
- Putative modulator of DNA gyrase, PmbA/TldD (111282)
consists of two different alpha+beta domains; d1: [duplication of alpha-beta(3)-alpha motif; 2 layers: a/b; antiparallel beta-sheet, order: 321456; strands 1, 2, 4 and 5 are twice longer than other secondary structures]; d2 [ complex fold; contains beta-barrel (n=5, S=10)]
- Oxysterol-binding protein-like (143999)
core: large meander beta-sheet of 12 strands wrapped around the N-terminal (distorted) alpha-hairpin; some similarity to transmembrane beta-barrel proteins
- ORC1-binding domain (144004)
complex fold, composed of an alpha hairpin, meander beta-sheet and a five-stranded barrel of unusual topology
- CofE-like (144009)
consists of two different domains; d1: beta-alpha-beta-alpha-beta(2)-alpha-beta, mixed sheet of 5 strands, order:15234, strands 2 and 3 are parralel; d2 is inserted in d1 after strand 2 and comprises a helix-turn-helix motif and two 3-stranded sheets
- Peptidoglycan deacetylase N-terminal noncatalytic region (144014)
consists of two different domains, d1: [alpha-beta(2)-alpha-beta(3); 3 layers: a/b/a; mixed beta-sheet, order 12345, strands 2 and 3 are parallel to each other with a left-handed crossover connection], d2: alpha-beta(3)-alpha; 2 layers; antiparallel beta-sheet, order 123]
- Non-globular alpha+beta subunits of globular proteins (56567)
not a true fold