Fold Children

• Microbial ribonucleases (53932)

  single helix packs against antiparallel beta-sheet

• SARS Nsp1-like (999406)

  complex alpha+beta fold; contains mixed beta-sheet barrel, n=6, S=10

• SP0830-like (999400)

  duplication: two beta-alpha-beta(2)-alpha-beta-alpha motifs are organized in ferredoxin-like subdomains swapped with the extra C-terminal helices

• YegP-like (999394)

  comprises two subunits or tandem repeats of beta(3)-alpha-beta motifs; these assemble with the formation of a single beta-sheet and swapping of the C-terminal strands

• RplX-like (999377)

  beta(2)-alpha-beta-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order: 213; some structural similarity to the PurS subunit/repeat (scop_cf 109622)

• NMB0513-like (999371)

  alpha(3)-beta(2)-alpha-beta(2); some similarity to the "winged helix" DNA-binding domain fold

• NRDP1 C-terminal domain-like (999365)

  alpha-beta-alpha(3)-beta(3); a pseudo barrel beta-sheet of an SH3-like topology, surrounded by helices

• NE1680-like (999358)

  beta(2)-alpha-beta-alpha-beta; 2 layers, a/b; antiparallel sheet, order 3124

• PH1570-like (999352)

  duplication: two beta(4)-alpha structural repeats, related by pseudo twofold symmetry; two extra helices in the linker region; single 8-standed antiparallel beta-sheet, order: 12348765

• MM3350-like (999346)

  beta(2)-alpha-beta(4); antiparallel beta-sheet; order: 216534; similar to a ubiquitin-like fold with the extra C-terminal strand inserted in the middle of the beta-sheet

• PSTPO5379-like (999340)

  complex fold; consists of two alpha+beta subdomains, one is inserted in the other

• FlaG-like (999334)

  alpha(2)-beta(3)-alpha; 2 layers: a/b; antiparallel beta-sheet, order: 123; partial similatity to the dsRBD-like fold(sop_cf 54767)

• AMPKBI-like (999328)

  comprises 3 short helices and 3-stranded meander beta-sheet; makes extensive intermolecular interactions

• SpoVG-like (999316)

  beta(5)-alpha; comprises a coiled antiparallel beta-sheet (order: 12345) packed against the C-terminal helix; the extensions of strands 4 and 5 form an isolated beta-hairpin

• PG1857-like (999307)

  alpha-beta-alpha-beta(2)-alpha(3); 3 layers, a/b/a; antiparallel beta-sheet, order: 132

• PB2 C-terminal domain-like (999301)

  alpha-beta-alpha-X-alpha-beta(2); 3 layers, a/b/a; antiparallel beta-sheet, order 132; connection between helices 2 and 3 runs over the edge of the beta-sheet

• gpW/gp25-like (999295)

  alpha(2)-beta(3); similar to one structural repeat of the Creatinase/aminopeptidase family and the C-terminal subdomain of PanC

• PA1123-like (999289)

  irregular array of short helices and two three-stranded beta-sheets

• TTHC002-like (999283)

  alpha-beta-alpha-beta(3); forms dimer with a single beta-sheet, folded in a barrel-like shape

• SMI1/KNR4-like (999277)

  alpha(4)-beta(4)-alpha; 3 layers: a/b/a; antiparallel beta-sheet, order 1234(meander)

• Rv2827c C-terminal domain-like (999265)

  multihelical array flanked by two three-stranded mixed beta-sheets

• Phosphoprotein oligomerization domain-like (999259)

  intertwinned homodimer of beta(2)-alpha-beta(2) motifs; 3 layers: b/a/b; each antiparallel beta-sheet is formed by the N-terminal beta-hairpin of one subunit and the C-terminal beta-hairpin of the other subunit; order 1243

• BTG domain-like (999253)

  alpha(2)-beta-alpha(2)-beta(3); four-helical bundle, capped at one end by a antiparallel beta-sheet, order:1234

• YqaI-like (999243)

  dimeric zinc-less 'zinc finger'-like fold; similar to the C-terminal strand-swapped B-box domain (scop_cf 57844)

• Shew3726-like (999237)

  beta(3)-alpha(n)-beta; 2 layers, a/b; mixed beta-sheet, order 1234, strands 3 and 4 are parallel with a left-handed crossover connection

• Acetoacetate decarboxylase-like (999231)

  complex fold: contains a 3-layer beta-sheet structure, which is folded in two conjoint barrels capped by helices; one rounded barrel has 7 strands, the other flattened barrel has 9 strands

• NMB0488-like (999223)

  duplication: two beta(3)-alpha motifs are related by pseudo twofold symmetry; single antiparrallel beta-sheet, order:321456, shaped into a half-barrel; helical linker region

• Taf5 N-terminal domain-like (999217)

  multihelical cluster with a C-terminal beta-alpha(2)-beta motif; one central buried helix; parallel beta-ribbon

• Jann2411-like (999207)

  unusual fold; consists of seven alpha-helices and three beta-hairpins

• BH3703-like (999201)

  alpha-beta(3)-alpha-beta(2)-alpha(2); antiparallel beta-sheet, order:32145; duplication: two alpha-beta(2) structural repeats are arranged with pseudo twofold symmetry

• Lp2179-like (999195)

  beta(2)-alpha-beta(4)-alpha-beta; contains two antiparallel beta-sheets (orders: 127 and 3456) packed against the longer C-terminal helix

• PG1388-like (999189)

  consists of 2 alpha+beta subdomains, each having a meander beta-sheet; d1: alpha(2)-beta(7); d2: alpha(2)-beta(2)-alpha(2)-beta(2)

• YdfO-like (999183)

  duplication: two alpha(2)-beta(3) motifs are related by pseudo twofold symmetry; single antiparrallel beta-sheet, order:321456

• ycgL-like (999177)

  beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel beta-sheet, order:3124

• NosL/MerB-like (999171)

  unusual fold; comprises two structural repeats of beta(2)-alpha-beta motifs, forming separate beta-sheets; probable duplication

• GINS/PriA/YqbF domain (999161)

  beta(4)-alpha-beta; 3-stranded antiparallel beta-sheet (strands 4,1 and 5) are covered on the same side by the helix and beta hairpin of strands 2 and 3; similarity to the L9 N-domain-like fold (scop_cf 55657) and the PsaD fold (scop_sf 64243)

• ATP12-like (999140)

  contains an N-terminal beta-sheet that forms a beta-triangle structure; the remainder is a multihelical array of long and short helices

• CPE0013-like (999130)

  beta(2)-alpha-beta(3); mixed, mostly antiparallel beta-sheet, folded in a half-barrel; order:31254; strand 3 is parallel to strand 1 and is shorter than the rest

• YehR-like (999124)

  beta(3)-alpha-beta(2)-alpha(3)-beta; 2 layers, a/b; antiparallel beta-sheet, order: 612354

• Ava3019-like (999118)

  alpha(2)-beta-alpha-beta(4); 2 layers, a/b; antiparallel beta-sheet, order: 32145; similarity to the insert domain of Glucose 6-phosphate dehydrogenase-like family (sop_fa 55376)

• BLRF2-like (999112)

  homodimer of alpha(2)-beta motif; also includes extra N-terminal helix of variable position

• EscU C-terminal domain-like (999106)

  alpha-beta(3)-alpha-beta-alpha(2); 3 layers, a/b/a; mixed beta-sheet, order: 4123, strand 2 is antiparallel to the rest

• YonK-like (999089)

  intertwined dimer of beta(3)-alpha-beta subunits; assembles further in octamer with formation of a wide 16-stranded beta-barrel

• Lysozyme-like (53954)

  common alpha+beta motif for the active site region

• Cysteine proteinases (54000)

  consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

• His-Me finger endonucleases (54059)

  core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures

• RNase A-like (54075)

  contains long curved beta-sheet and 3 helices

• EndoU-like (142876)

  comprises several helices and two three-stranded antiparallel beta-sheets; similar architecture to the RNase A-like fold (scop_cf 54075)

• Prion-like (54097)

  beta-alpha-beta-alpha(2); antiparallel beta-ribbon

• LysM domain (54105)

  beta-alpha(2)-beta; antiparallel strands

• gpW/XkdW-like (64209)

  alpha-beta(2)-alpha; antiparallel hairpin

• Hypothetical protein MTH677 (110782)

  alpha-beta(2)-alpha; 2 layers a/b; antiparallel beta-hairpin

• GTF2I-like repeat (117772)

  alpha(2)-beta-alpha-beta-alpha; 2 layers: a/b; antiparallel beta-ribbon

• Urease, gamma-subunit (54110)

  alpha(3)-beta(2); antiparallel hairpin

• IL8-like (54116)

  beta(3)-alpha

• DNA-binding domain (54170)

  beta(3)-alpha; 2 layers: alpha/beta

• Penicillin-binding protein 2x (pbp-2x), c-terminal domain (54183)

  alpha1-beta3; 2 layers: alpha/beta; order 132

• Dodecin subunit-like (88797)

  beta-alpha-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 132

• Ribosomal proteins S24e, L23 and L15e (54188)

  beta-(alpha)-beta-alpha-beta(2); 3 layers: alpha/beta/alpha; antiparallel beta-sheet: order 1243

• Ribosome binding domain-like (100965)

  beta-(2)-alpha(2)-beta(2); 2 layers: beta/alpha; antiparallel beta-sheet: order 1243; topological similarity to the common core of ribosomal proteins L23 and L15e

• TFB5-like (142896)

  beta-alpha-beta(2)-alpha; 2 layers, a/b; antiparallel sheet, order: 132; dimerises in solution (PDB 2jnj) via extended N-terminal strand

• Obg GTP-binding protein C-terminal domain (102740)

  beta-(2)-alpha(3)-beta(2); 2 layers: beta/alpha; mixed beta-sheet: order 1234; strands 2 and 3 a parallel to each other

• HIT-like (54196)

  alpha-beta(3)-alpha-beta(2); 3 layers: alpha/beta/alpha

• Secretion chaperone-like (69634)

  alpha-beta(3)-alpha-beta(2)-alpha; 2 layers: alpha/beta

• DNA-binding domain of intron-encoded endonucleases (64495)

  beta(2)-alpha(2)-beta; 2 layers; 3-stranded antiparallel beta-sheet, order 213; HTH motif; also includes the extra N-terminal, DNA minor groove-binding helix

• MotA C-terminal domain-like (69651)

  alpha-beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta

• YktB/PF0168-like (142912)

  alpha-beta(4)-alpha-beta(2)-alpha-beta-alpha; 2 layers, a/b; antiparallel beta-sheet, order: 1234756; half-barrel shape; topological similarity to the MotA C-terminal domain-like fold (scop_cf 69651) and the Secretion chaperone-like fold (scop_cf 69634)

• Mago nashi protein (89816)

  beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta; antiparallel beta-sheet, order: 651234

• WGR domain-like (142920)

  beta(4)-alpha-X-beta; 2 layers, a/b; antiparallel beta-sheet, order 51234; the beta-hairpin insetrion in strand 1 results in the formation of a beta-triangle structure

• Ribosomal protein S5 domain 2-like (54210)

  core: beta(3)-alpha-beta-alpha; 2 layers: alpha/beta; left-handed crossover

• beta-Grasp (ubiquitin-like) (54235)

  core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

• WWE domain (117838)

  beta(2)-alpha-beta(4); antiparallel folded beta-sheet (half-barrel), order 216543

• FAD-linked reductases, C-terminal domain (54372)

  alpha+beta sandwich

• Cystatin-like (54402)

  Core: alpha-beta(4); helix packs against coiled antiparallel beta-sheet

• Nuclease A inhibitor (NuiA) (82601)

  alpha-beta-alpha-beta-alpha(2)-beta(3); antiparallel beta-sheet; order: 15432

• Colicin D/E5 nuclease domain (102823)

  alpha(2)-beta(4)-alpha, 2 layers: alpha/beta, antiparallel beta sheet, meander

• RelE-like (143010)

  beta-alpha(2)-beta(4), 2 layers; a/b, antiparallel beta-sheet; order 15432

• Hypothetical protein SAV1430 (110835)

  beta(3)-alpha-beta(2)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet, order: 12543

• Ns1 effector domain-like (143020)

  beta-X-beta(5)-alpha-beta-alpha; 2 layers: a/b; bifurcated beta-sheet; order 23654[1,7]

• YbaB-like (82606)

  core: alpha-beta(3)-alpha, 2 layers:alpha/beta, three-stranded antiparallel beta sheet, strand order 123

• Kinetochore globular domain-like (143025)

  core: alpha-beta(3)-alpha; variant: alpha-beta(4)-alpha(2)

• L35p-like (143033)

  core: alpha-beta(3)-alpha; 2layers a/b

• Cell division protein ZapA-like (102828)

  core: beta(2)-alpha(2), 2 layers: alpha/beta; long C-terminal helix forms dimeric parallel and tetrameric antiparallel coiled coils

• ssDNA-binding transcriptional regulator domain (54446)

  helix-swapped dimer of beta(4)-alpha motifs

• Photosystem I subunit PsaD (64233)

  beta-BETA(2)-beta-alpha-beta(2); antiparallel sheet: order 2134 packed against helix and BETA-hairpin on the same side; irregular C-terminal tail

• MHC antigen-recognition domain (54451)

  dimeric

• UBC-like (54494)

  alpha-beta(4)-alpha(3); core: meander beta-sheet plus one helix 2

• SAND domain-like (63762)

  core: three short helices packed against a barrel-like beta-sheet; some similarity to the SH3-like fold

• Coronavirus NSP8-like (143075)

  core: alpha-beta(2)-alpha-beta(4)-alpha-beta; bifurcated barrel-like beta-sheet

• ParB/Sulfiredoxin (110848)

  beta*-alpha-beta(2)-alpha-beta-alpha; mixed beta sheet forms a partly open barrel: (n*=4, S*=8)

• Gamma-glutamyl cyclotransferase-like (110856)

  beta-alpha-beta(4)-alpha-beta(2); contains beta-sheet barrel (n=5, S=8)

• BB1717-like (143080)

  complex fold with a bifurcated beta-sheet structure surrounded by helices; contains beta-sheet barrel, closed (n=5, S=8)

• AF0104/ALDC/Ptd012-like (117855)

  duplication: consists of two similar beta-alpha-beta(4) motifs

• NSFL1 (p97 ATPase) cofactor p47, SEP domain (102847)

  beta(3)-alpha(2)-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other

• TTHA1013/TTHA0281-like (143099)

  beta(3)-alpha-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other; topological similarity to the SEP domain fold (scop_cf 102847); dimerises via the long C-terminal strand with the formation of a single beta-sheet

• Diaminopimelate epimerase-like (54505)

  mixed beta-sheet folds into a barrel (n=8, S=14) around the central helix

• GFP-like (54510)

  beta-sheet folds into a barrel (n=11, S=14) around the central helix

• Tubby C-terminal domain-like (54517)

  beta-sheet folds into a barrel (n=12, S=12) around the central helix

• Pili subunits (54522)

  contains very long N-terminal helix, which end is packed against beta-sheet

• Mitochondrial glycoprotein MAM33-like (54528)

  core: beta(7)-alpha(2); N- and C-terminal extensions form a coiled coil subdomain

• NAP-like (143112)

  core: central meander 4-stranded beta-sheet (order: 1234) transversed by a C-terminal helix

• Polo-box domain (82614)

  beta(6)-alpha; antiparallel beta-sheet, meander

• mRNA decapping enzyme DcpS N-terminal domain (102859)

  beta(3)-alpha-beta(3)-alpha; 3 layers a/b/a

• Inhibitor of vertebrate lysozyme, Ivy (89871)

  alpha(2)-beta(5)-alpha(2); 3 layers a/b/a; meander beta-sheet

• FKBP-like (54533)

  core: beta(2)-alpha-beta(2); antiparallel beta-sheet

• Ribosomal protein S16 (54564)

  beta(4)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet, order: 51234

• Ribosomal protein S19 (54569)

  alpha-beta-X-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 123

• YefM-like (143119)

  core: beta-alpha(2)-beta(2)-alpha; mixed beta-sheet, order:123, strands 1 and 2 are parallel; forms compact dimer with a single beta-sheet;

• Ribosomal protein L31e (54574)

  beta-alpha-beta-(alpha)-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 1342

• Allophycocyanin linker chain (domain) (54579)

  beta(2)-alpha-beta; 2 layers: alpha/beta

• Cdc48 domain 2-like (54584)

  beta-alpha-beta(3); 2 layers: alpha/beta

• Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase (54592)

  beta-alpha-beta(3); 2 layers: alpha/beta

• Chromosomal protein MC1 (102874)

  beta(2)-alpha-beta(3); 2 layers: alpha/beta

• beta-hairpin-alpha-hairpin repeat (74651)

  multiple repeats of beta(2)-alpha(2) motif

• Proguanylin (89889)

  beta(2)-alpha(3)-beta; two layers: alpha/beta; antiparallel sheet: order 213

• SecB-like (54610)

  beta(4)-alpha(2); two layers: alpha/beta; antiparallel sheet: order 1432

• MesJ substrate recognition domain-like (82828)

  beta-alpha(2)-beta(3); 2 layers: a/b; antiparallel beta-sheet, order:1432

• FYSH domain (89894)

  beta(2)-alpha(2)-beta(2)-alpha-beta; two layers: alpha/beta; antiparallel sheet: order 51234

• VSV matrix protein (75403)

  beta-alpha(2)-beta(4)-alpha-beta(2); two layers: alpha/beta; bifurcated coiled beta-sheet: order of the first 5 strands: 23154

• DNA-binding domain of Mlu1-box binding protein MBP1 (54615)

  beta(4)-alpha(2)-beta(2)-alpha; antiparallel sheet: order 123465

• Heme-binding protein A (HasA) (54620)

  beta-alpha-beta(6)-alpha(2); antiparallel sheet: order 165432

• Chalcone isomerase (54625)

  beta(3)-alpha(2)-beta-alpha(2)-beta3; 2 layers alpha/beta; antiparallel sheet: order 1234567

• Coproporphyrinogen III oxidase (102885)

  alpha-beta(6)-alpha(2)-beta-alpha(n); 3 layers alpha/beta/alpha; antiparallel sheet: order 1234567

• Hypothetical protein Ta1206 (102890)

  beta(4)-alpha-beta(2)-alpha(2); mixed, predominately antiparallel beta-sheet, order: 123465, strands 4 and 5 are parallel to each other

• CBS-domain (54630)

  core: beta-alpha-beta(4); 2 layers: alpha/beta

• Thioesterase/thiol ester dehydrase-isomerase (54636)

  core: beta-alpha-beta(4); 2 layers: alpha/beta

• DLC (54647)

  core: beta-alpha(2)-beta-X-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 1342

• CI-2 family of serine protease inhibitors (54653)

  alpha+beta sandwich; loop across free side of beta-sheet

• Integrin beta tail domain (69686)

  alpha-beta-loop-beta(3); loop across free side of beta-sheet

• alpha/beta-Hammerhead (54664)

  core: beta-BETA-alpha-beta-BETA-beta-alpha; contains a beta-hammerhead motif similar to that in barrel-sandwich hybrids

• POZ domain (54694)

  core: beta(2)-alpha(2)-beta(2)-alpha(2); 2 layers a/b; mixed sheet: 2143

• EF-Ts domain-like (54712)

  beta(2)-alpha(n)-beta; 2 layers a/b; antiparallel sheet: 123

• Fe,Mn superoxide dismutase (SOD), C-terminal domain (54718)

  alpha-beta(2)-alpha-beta-alpha(2); 3 strands of antiparallel sheet: 213

• ClpS-like (54735)

  beta-alpha(2)-beta-alpha-beta; 2 layers, alpha/beta

• Hypothetical protein MTH1880 (75411)

  beta-alpha-beta(2)-alpha(2); 3 layers, alpha/beta/alpha; antiparallel beta-sheet: order 123

• Ribosomal L11/L12e N-terminal domain (54746)

  beta-alpha(2)-beta(2); 2 layers, alpha/beta; antiparallel beta-sheet: order 123

• Anti-LPS factor/recA domain (54751)

  alpha-beta(3)-alpha(2); 2 layers, alpha/beta

• Signal recognition particle alu RNA binding heterodimer, SRP9/14 (54761)

  (beta)-alpha-beta(3)-alpha; 2 layers, alpha/beta

• dsRBD-like (54767)

  alpha-beta(3)-alpha; 2 layers: alpha/beta

• 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain (110920)

  duplication: consists of two beta(3)-alpha repeats; 3 layers, beta/alpha/beta

• SRP19 (69694)

  beta-alpha-beta(2)-alpha; 2 layers: alpha/beta

• SufE/NifU (82648)

  alpha(2)-beta(3)-alpha(3); 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123

• DNA-binding protein Tfx (89914)

  alpha(3)-beta-alpha(2)-beta(2); 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123

• Eukaryotic type KH-domain (KH-domain type I) (54790)

  beta-alpha(2)-beta(2)-alpha; 2 layers: alpha/beta

• Alpha-lytic protease prodomain-like (54805)

  core: alpha-beta(2)-(alpha)-beta; 2 layers: alpha/beta

• Nucleotidyltransferase (81302)

  core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order of core strands: 123

• Nqo5-like (143242)

  core: alpha-beta(2)-alpha-beta(3); 2 layers, a/b; mixed beta-sheet, order 12534, strands 2 and 5 are parallel

• Ribosomal protein S3 C-terminal domain (54820)

  alpha(2)-beta(4); 2 layers: alpha/beta; antiparallel beta-sheet: order 2143

• Transcription factor NusA, N-terminal domain (69704)

  alpha-beta(3)-alpha-beta-alpha; bifurcated coiled beta-sheet

• Enolase N-terminal domain-like (54825)

  beta(3)-alpha(3); meander and up-and-down bundle

• Ribosomal protein L22 (54842)

  beta-alpha(3)-beta(2); 2 layers: alpha/beta; related to the enolase/MLE N-domain fold by a circular permutation

• Prokaryotic ribosomal protein L17 (64262)

  alpha-beta-alpha(3)-beta(2); 2 layers: alpha/beta;

• GroEL-intermediate domain like (54848)

  3-helical bundle packed against 3-stranded mixed beta-sheet

• PX domain (64267)

  beta(3)-alpha(4); meander beta-sheet packed against array of helices; contains Pro-rich stretch

• DsrC, the gamma subunit of dissimilatory sulfite reductase (69720)

  beta(3)-alpha(5); meander beta-sheet packed against array of helices

• DNA damage-inducible protein DinI (54856)

  beta-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed sheet 213; crossing loops

• HSP90 C-terminal domain (110941)

  alpha-beta(3)-alpha(3); 2 layers, a/b; mixed beta-sheet, order:132; crossing loops

• Ferredoxin-like (54861)

  alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2

• PurS-like (109622)

  consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold

• Dystroglycan, domain 2 (111005)

  beta-alpha-beta-X-beta(2)-alpha(2)-beta; antiparallel beta-sheet, order 24153; topological similarity to the ferredoxin-like fold (scop_cf 54861)

• Pseudouridine synthase (100877)

  consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold

• Folate-binding domain (103024)

  duplication: consists of two beta(2)-alpha-beta(3)-alpha subdomains swapped with the first strands

• THUMP domain (143436)

  contains mixed 8-stranded beta-sheet, folded into a half-barrel and covered with 4 helices on the outside; order 32148756; strands 5, 6 and 7 are parallel

• AMMECR1-like (143446)

  duplication; contains two beta(2)-alpha-beta(2) structural repeats, swapped with C-terminal strands; extra N-terminal helix and C-terminal strand

• YehU-like (118000)

  beta-alpha(2)-beta(2)-alpha; 3 layers, alpha/beta/alpha; antiparallel beta-sheet: order 123

• Hypothetical protein YwqG (103031)

  duplication: contains two similar beta-x-beta(4) motifs swapped with the first strands

• VC0467-like (143455)

  complex fold; contains bifurcated beta-sheet structure folded into pseudo barrel

• Lesion bypass DNA polymerase (Y-family), little finger domain (100878)

  beta-alpha-beta(2)-alpha-beta; antiparallel beta-sheet: order 1423; "reversed" ferredoxin-like topology

• ImmE5-like (143468)

  alpha-beta(2)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order 213

• Ribosomal protein L30p/L7e (55128)

  core: beta-alpha-beta-alpha-beta; antiparallel beta-sheet: order 312; some similarity to the ferredoxin-like fold

• Chorismate lyase-like (64287)

  duplication of alpha(2)-beta(3) motif; antiparallel beta sheet, order 123654

• TM1622-like (143476)

  alpha-beta(3)-alpha-beta(4)-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order: 1237654

• Probable bacterial effector-binding domain (55135)

  duplication of beta-alpha-beta(2) motif: antiparallel beta sheet forms barrel (n=6, S=12)

• CheC-like (103038)

  duplication: tandem repeat of two intertwined alpha-beta-(X)-beta(2) motifs

• LigT-like (55143)

  duplication of beta-alpha-beta-alpha-beta motif: antiparallel beta sheet forms barrel (n=6, S=8) similar to the barrel of prokaryotic DNA topoisomerases I and III

• Pepsin inhibitor-3 (55148)

  duplication of beta(3)-alpha(2) motif: meander beta sheets form barrel-like structure

• CYTH-like phosphatases (55153)

  duplication of beta-alpha-beta(3) motif: antiparallel beta sheet forms wide barrel (n=8, S=16) with a channel running through it

• Antiparallel beta/alpha barrel (PT-barrel) (143491)

  tandem repeat of five alpha(2)-beta(2) motifs; antiparallel beta-sheet barrel, closed; n=10, S=10; order 123456789A; there is a channel along the barrel axis

• eIF1-like (55158)

  beta(2)-alpha-beta(2)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet: order 51243

• Hedgehog/DD-peptidase (55165)

  alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta

• Alpha-L RNA-binding motif (55173)

  alpha(2)-beta(2)-loop-beta; 2 layers: alpha/beta

• RRF/tRNA synthetase additional domain-like (55185)

  core: alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta

• LuxS/MPP-like metallohydrolase (63410)

  core: beta-alpha-beta(2)-alpha(2); 2 layers: alpha/beta

• IF3-like (55199)

  beta-alpha-beta-alpha-beta(2); 2 layers; mixed sheet 1243, strand 4 is antiparallel to the rest

• PUG domain-like (143502)

  alpha(2)-beta-alpha(2)-beta(2)-alpha; cluster of helices with a small antiparallel beta-sheet on one side; order 132; topological similarity to the fold of an extended R3H domain (PDB 1whr)

• Ribosome binding protein Y (YfiA homologue) (69753)

  beta-alpha-beta(3)-alpha; 2 layers; mixed sheet 1234, strand 3 is antiparallel to the rest

• TolA/TonB C-terminal domain (74652)

  beta(2)-alpha-beta; 2 layers, alpha/beta; left-handed beta-alpha-beta unit in non-swapped monomer

• Yeast killer toxins (55220)

  beta-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta; left-handed crossover connection

• Cell division protein MinE topological specificity domain (55228)

  dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta

• Hypothetical protein YoaG (103062)

  dimer of beta(2)-alpha motifs ; 2 layers, alpha/beta; reverse MinE topology

• Nucleocapsid protein dimerization domain (103067)

  dimer of alpha-beta(2)-alpha motifs ; 2 layers, alpha/beta

• Cyanase C-terminal domain (55233)

  intertwined dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta

• Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains (82713)

  Intertwined pseudo hexamer of an alpha+beta motif

• RuBisCO, small subunit (55238)

  alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta

• DCoH-like (55247)

  beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta

• TRCF domain-like (143516)

  beta-alpha(3)-beta(2)-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed beta sheet, order 12354, strands 1 and 2 are parallel; some topological similarity to the DCoH-like fold (scop_cf 55247)

• Hypothetical protein Yml108w (100886)

  beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta; mixed beta-sheet 2143, strands 1 and 4 are parallel

• MutS N-terminal domain-like (55266)

  beta(2)-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta

• GYF/BRK domain-like (55276)

  beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta

• GTP cyclohydrolase I feedback regulatory protein, GFRP (69760)

  beta(2)-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta, antiparallel beta-sheet: order 342165

• RL5-like (55281)

  beta-alpha-beta(2)-alpha-beta(3)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet: order 231654

• RPB5-like RNA polymerase subunit (55286)

  core: beta-alpha-beta-alpha-beta(2); 2 layers, alpha/beta

• Bacillus chorismate mutase-like (55297)

  core: beta-alpha-beta-alpha-beta(2); mixed beta-sheet: order: 1423, strand 4 is antiparallel to the rest

• YjbQ-like (111037)

  beta(2)-alpha-beta(2)-alpha(2)-beta(3); contains a beta-sandwich: 7 strands in 2 sheets; trimerizes with orthogonally packed beta-sheets

• Tautomerase/MIF (55330)

  (beta-alpha-beta)2; 2 layers: alpha/beta; mixed beta-sheet
  generally forms trimers with three closely packed beta-sheets

• FwdE/GAPDH domain-like (55346)

  core: alpha-beta-alpha-beta(3); mixed sheet: 2134, strand 2 is parallel to strand 1

• Hypothetical protein PF0899 (111056)

  alpha-beta-alpha-beta(4); 2 layers: a/b; mixed beta-sheet, order 23145, strands 1 and 3 are parallel; similar to the GAPDH C-terminal domain-like fold (scop_cf 55346)

• Major capsid protein gp5 (56562)

  unusual fold; contains PF0899-like core, decorated with additional structure

• MK0786-like (143559)

  alpha(2)-beta(4); 2 layers: a/b; antiparallel beta-sheet, order 1234 (meander)

• YkuJ-like (143566)

  alpha-beta(4)-alpha; 2 layers a/b; antiparallel beta-sheet, order 1234

• N domain of copper amine oxidase-like (55382)

  alpha-beta(5)-alpha; 2 layers: alpha/beta; meander antiparallel sheet

• Aha1/BPI domain-like (55393)

  core: [beta]-alpha-beta(5)-alpha; 2 layers: alpha/beta; antiparallel beta-sheet, meander

• Subtilisin inhibitor (55398)

  alpha+beta sandwich

• RNA bacteriophage capsid protein (55404)

  6-standed beta-sheet followed with 2 helices; meander

• eIF4e-like (55417)

  beta(2)-alpha-beta(2)-alpha-beta(2)-alpha-beta-2; 2 layers: alpha/beta; antiparallel sheet: 21356478

• CO dehydrogenase flavoprotein C-domain-like (55423)

  core: beta(3,4)-alpha(3); alpha+beta sandwich

• SRF-like (55454)

  alpha-beta(2)-alpha; dimer; 3 layers a/b/a; antiparallel beta-sheet

• Origin of replication-binding domain, RBD-like (55463)

  alpha-beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel sheet 41325

• SARS receptor-binding domain-like (143586)

  core: 3 layers, a/b/a; antiparallel beta-sheet of 5 strands, order 13542

• Hut operon positive regulatory protein HutP (111063)

  alpha(2)-beta-alpha(2)-beta(3); 3 layers: a/b/a; antiparallel beta-sheet: order 1234

• Hypothetical protein yfbM (111068)

  beta-alpha(2)-beta-alpha(2)-beta(2)-alpha(n)-beta; 3 layers: a/b/a; antiparallel beta-sheet, order: 21543

• TTHA1528-like (143591)

  beta-alpha-beta(3)-alpha-beta-alpha(2)-beta; 3 layers: a/b/a; mixed beta-sheet, order: 143256, parallel strands' pairs are 1-4 and 2-5

• YojJ-like (143596)

  alpha-beta-X-beta-alpha-beta(2)-alpha-beta(3); 3 layers: a/b/a; 7-stranded mixed beta-sheet, order 2431567; strands 1 and 3 are parallel to each other

• STIV B116-like (143601)

  subunit fold consists of mixed 5-stranded beta-sheet, order:31452, strand 5 is antiparallel to the rest, with 3 helices on one side; dimerises with the formation of a single 10-stranded beta-sheet; strand 2 is in the dimer interface

• Bacillus phage protein (111073)

  alpa-beta(3)-alpha-beta(3)-alpha; 3 layers: b/a/b, 3-helical bundle flanked by two 3-stranded meander beta-sheets

• FMN-dependent nitroreductase-like (55468)

  core: (alpha-beta-alpha-beta)2; 3 layers a/b/a; antiparallel beta-sheet: 1243

• N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 (55480)

  alpha-beta-alpha(2)-beta(3)-alpha; 3 layers a/b/a; antiparallel beta-sheet: 4123

• Zincin-like (55485)

  contains mixed beta sheet with connection over free side of the sheet

• SH2-like (55549)

  3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices

• HPr-like (55593)

  beta-alpha-beta(2)-alpha-beta-alpha; 2 layers: a/b; antiparallel sheet 1423

• TrkA C-terminal domain-like (116725)

  beta-X-beta(2)-X-beta-alpha; pseudo barrel capped by helix at one end; topological similarity to the HPr-like fold

• Hypothetical protein YjiA, C-terminal domain (90001)

  beta-alpha-beta(4)-alpha; 2 layers: a/b; antiparallel sheet 15234; topological similarity to the HPr-like fold

• YggU-like (69785)

  beta(2)-loop-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243; some similarity to the Homing endonuclease-like fold

• Homing endonuclease-like (55603)

  alpha-beta(2)-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243

• T-fold (55619)

  beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
  tunnel-shaped: its known members form wide oligomeric barrels different sizes

• Cell cycle regulatory proteins (55636)

  beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1243
  can form strand-exchange dimers

• BLIP-like (55647)

  alpha(2)-beta(4); 2 layers: alpha/beta

• Ribosomal protein L9 C-domain (55652)

  alpha-beta-alpha(2)-beta(2); 2 layers: alpha/beta

• MbtH/L9 domain-like (55657)

  beta(2)-alpha-beta-alpha; 3 layers: alpha/beta/alpha

• Tombusvirus P19 core protein, VP19 (103144)

  beta(2)-alpha-beta(2)-alpha; 2 layers: alpha/beta; antiparallel sheet: order 2134

• Ribonuclease PH domain 2-like (55665)

  beta(2)-alpha-beta(2)-alpha; 3 layers: alpha/beta/alpha; antiparallel sheet: order 2134

• Regulatory factor Nef (55670)

  alpha(2)-beta(4)-alpha; 3 layers: alpha/beta/alpha

• CytB endotoxin-like (55675)

  core: beta-alpha(2)-beta-alpha(2)-beta(4); 3 layers: a/b/a

• Class II aaRS and biotin synthetases (55680)

  contains large mixed beta-sheet

• Subdomain of clathrin and coatomer appendage domain (55710)

  beta-alpha-beta-alpha-beta(4)-alpha; 3 layers: a/b/a; bifurcated antiparallel beta-sheet

• SCP-like (55717)

  alpha-beta(3)-(crossover)-beta-(alpha)-beta; 3 layers: a/b/a; antiparallel beta-sheet of 5 strands; order: 32145

• Ta1353-like (103164)

  core: beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel beta-sheet of 5 strands; order: 51423;

• Mog1p/PsbP-like (55723)

  (beta-hairpin)-beta(3)-alpha-beta(4)-alpha; 3 layers: a/b/a; antiparallel beta-sheet of 7 strands; order: 1237654

• Acyl-CoA N-acyltransferases (Nat) (55728)

  3 layers: a/b/a; contains mixed beta-sheet

• Gelsolin-like (55752)

  3 layers: a/b/a; contains mixed beta-sheet

• PHP14-like (143723)

  beta(3)-alpha-beta(2)-alpha-beta; 3 layers, a/b/a; mixed beta-sheet, half-barrel, order: 132456; strands 2 and 5 are antiparallel to the rest

• Profilin-like (55769)

  core: 2 alpha-helices and 5-stranded antiparallel sheet: order 21543; 3 layers: alpha/beta/alpha

• Ligand-binding domain in the NO signalling and Golgi transport (111125)

  an N-terminal helical bundle and the C-terminal alpha-beta(2)-alpha-beta(2) subdomain enclose a ligand-binding cavity

• Phage tail protein-like (143748)

  alpha-beta-X-beta(2)-alpha-beta(2); 2 layers: a/b; mixed beta-sheet: order 12354, strands 1 and 2 are parallel

• PR-1-like (55796)

  alpha-beta-alpha-beta-alpha(2)-beta(2); 3 layers, alpha/beta/alpha; mixed sheet: order 1342

• Phoshotransferase/anion transport protein (55803)

  beta-alpha(2)-beta(3)-alpha(3); 3 layers, alpha/beta/alpha; mixed sheet: order 1342; loop crossing

• Nudix (55810)

  beta(2)-alpha-beta(3)-alpha; 3 layers: alpha/beta/alpha; mixed sheet
  contains beta-grasp motif

• 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain (55815)

  core: alpha-beta(2)-alpha-beta(2)-alpha-beta; 3 layers; mixed sheet: order 31425

• YrdC/RibB (55820)

  core: alpha-beta(2)-alpha-beta-alpha(2)-beta(2)-alpha-beta-alpha-beta; 3 layers; mixed twisted sheet of 7 strands; order 7126354; strands 7 and 1 are parallel to each other

• GIY-YIG endonuclease (82770)

  beta(2)-alpha(2)-beta-alpha-(beta); strand 4 is very short; 3 layers; antiparallel (mixed) beta-sheet; order 312(4)

• YbaK/ProRS associated domain (55825)

  core: alpha-beta-alpha-beta(2)-(alpha-beta)2-alpha-beta(2)-alpha-beta; 3 layers; bifurcated mixed sheet

• Thymidylate synthase/dCMP hydroxymethylase (55830)

  contains large mixed beta-sheet

• Thymidylate synthase-complementing protein Thy1 (69795)

  complex alpha+beta fold; contains antiparallel 5-stranded beta-sheet: order 12354

• N-acetylmuramoyl-L-alanine amidase-like (55845)

  contains mixed beta-sheet

• Cytochrome b5-like heme/steroid binding domain (55855)

  beta-alpha-beta(2)-alpha(1,2)-(beta)-alpha(2)-beta; 3 layers: a/b/a; antiparallel beta-sheet, order: 1532(4)

• DUSP-like (143790)

  alpha-beta-alpha-X-beta-alpha-beta; three-helical bundle capped at one end by antiparallel beta-sheet, order: 213

• DNA topoisomerase I domain (55868)

  beta(2)-alpha-beta-(alpha)-beta(2); left-handed crossover between strands 2 & 3

• ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (55873)

  8-stranded mixed beta-sheet; 2 layers: alpha/beta

• Sporulation response regulatory protein Spo0B (55889)

  core: alpha-beta-alpha-beta(2)-(alpha)-beta(2)

• Ribonuclease Rh-like (55894)

  alpha+beta fold

• YlxR-like (64375)

  alpha+beta fold; could have evolved from a glucocorticoid receptor-like zinc finger domain

• YggX-like (111147)

  beta(2)-alpha(3); contains zinc-less 'zinc finger'-like fold (scop_cf 57715; see also scop_cf 64375)

• L28p-like (143799)

  unusual fold consisting of three beta-hairpins, that form a paper clip-like structure, and two helices; could have evolved from a glucocorticoid receptor-like zinc finger domain (scop_cf 57715)

• Ornithine decarboxylase C-terminal domain (55903)

  complex alpha+beta motif

• Pentein, beta/alpha-propeller (55908)

  duplication: composed of 5 alpha-beta(2)-alpha-beta units arranged around pseudo fivefold axis

• Creatinase/aminopeptidase (55919)

  duplication: composed of two very similar alpha+beta folds

• Glutamine synthetase/guanido kinase (55930)

  duplication: common core consists of two beta-alpha-beta2-alpha repeats

• TBP-like (55944)

  beta-alpha-beta(4)-alpha

• XisI-like (143846)

  alpha-beta(4)-alpha-beta-alpha; 2 layers, a/b; antiparallel beta-sheet, order 1234, meander; the open side of beta-sheet provides dimerization interface

• S-adenosylmethionine synthetase (55972)

  duplication: consists of 3 similar intertwined domains
  structural repeat: beta-alpha-beta(2)-alpha-beta; two layers, alpha/beta

• DNA clamp (55978)

  contains two helices and two beta sheets
  duplication: fold has internal pseudo two-fold symmetry

• Hypothetical protein TM0160 (103255)

  duplication: consists of two beta(3)-alpha(2) structural repeats; single barrel-like beta-sheet

• Molybdenum cofactor-binding domain (56002)

  beta(2)-alpha-beta-alpha-beta; 2 layers: a/b; mixed sheet: order 1243: crossing loops

• Nitrite and sulphite reductase 4Fe-4S domain-like (56013)

  beta-alpha-beta-alpha-beta(3)-alpha(2,3); mixed sheet: order 12345; left-handed crossover connection between strands 1 and 2

• DeoB insert domain-like (143855)

  alpha-beta-X-beta(2)-alpha-beta(2); 2 layers, a/b; mixed beta-sheet of 5 strands, order 12345; strands 2 and 5 are antiparallel to the rest

• The spindle assembly checkpoint protein mad2 (56018)

  core: alpha(2)-beta(2)-alpha-beta; mixed sheet: order 213

• Phospholipase D/nuclease (56023)

  beta-alpha-beta-alpha-beta-alpha-beta(4)-alpha; mixed sheet: order 1765234

• CorA soluble domain-like (143864)

  beta(2)-alpha-beta-alpha(2)-beta(4)-alpha(3); 3 layers: a/b/a; mixed beta-sheet, order 2137654; strands 3 and 7 are parallel

• Monooxygenase (hydroxylase) regulatory protein (56028)

  corner-like structure formed by two sheets and filled in with 2-3 helices

• PurM C-terminal domain-like (56041)

  3 layers: alpha/beta/alpha; partial topological similarity to the ferredoxin-like fold

• PF0523-like (143869)

  beta-alpha-beta-alpha(3)-beta-alpha-beta-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order 4132; some similarity to the PurM C-terminal domain-like fold (scop_cf 56041)

• Chorismate synthase, AroC (103262)

  duplication: consists of two DCoH-like beta(2)-alpha-beta(2)-alpha structural repeats; 3 layers, beta/alpha/beta

• Hsp33 domain (64396)

  3 layers: beta/alpha/beta; buried helix

• MTH1598-like (69818)

  beta(2)-alpha-beta-alpha-beta(4); 3 layers: beta/alpha/beta; some similarity to the Hsp33 fold

• Protein-L-isoaspartyl O-methyltransferase, C-terminal domain (68929)

  beta-alpha-beta(4)-alpha-beta(2); 3 layers: beta/alpha/beta; buried helix

• OsmC-like (82783)

  swapped dimer of beta(3)-alpha-beta(2)-alpha(2)-beta subunits; mixed beta-sheet; order: 321[4][5][6]; buried helix

• Hypothetical protein HI1480 (103276)

  beta-alpha(4)-beta-alpha-beta; segregated alpha-helical and beta-sheet subdomains; dimeric beta-sheet barrel: n=6, S=10

• ERH-like (143874)

  beta(2)-alpha(2)-beta(2)-alpha; antiparallel beta-sheet, order:2134; helices are arranged in a bundle rather than packed agains beta-sheet; dimerises via with the formation of a flattened beta-barel: closed n=8, S=10

• Ribosomal protein S8 (56046)

  consists of 2 different alpha+beta subdomains arranged in a 4-layer structure: b/a/b/a

• Ribosomal protein L6 (56052)

  consists of two beta-sheets and one alpha-helix packed around single core

• NE0471 N-terminal domain-like (143879)

  beta(3)-alpha(n)-beta(3)-alpha; the two meander beta-sheets and helices are packed against the same core

• RGC domain-like (143884)

  consists of two beta-sheets and four helices eclosing a cental cavity

• Smc hinge domain (75552)

  consists of 2 different alpha+beta subdomains; forms subdomain-swapped dimers

• DNA mismatch repair protein MutL (118115)

  consists of two different alpha+beta (sub)domains; d1: [beta(3)-alpha-(insert of d2)-alpha(2)-beta; 2 layers, a/b; antiparallel sheet, order: 1234]; d2: [beta-alpha-beta(2)-alpha(2); 2 layers, a/b; antiparallel sheet, order: 132]

• ATP-grasp (56058)

  Consists of two subdomains with different alpha+beta folds
  shares functional and structural similarities with the PIPK and protein kinase superfamilies

• SAICAR synthase-like (56103)

  consists of two alpha+beta subdomains

• Protein kinase-like (PK-like) (56111)

  consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

• FAD-binding/transporter-associated domain-like (56175)

  consists of two alpha+beta subdomains

• Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain (56193)

  consists of two alpha+beta subdomains

• Methenyltetrahydromethanopterin cyclohydrolase (56198)

  consists of two alpha+beta subdomains

• Prim-pol domain (56746)

  consists of two alpha+beta domains

• Hect, E3 ligase catalytic domain (56203)

  consists of two alpha+beta domains; the N-terminal domain is array of helices and beta-hairpins; the C-terminal domain is an a/b sandwich with one left-handed beta-alpha(n)-beta unit; conformational flexibility of domain orientation

• Nitrile hydratase alpha chain (56208)

  4 layers a/b/b/a; inside is a sandwich of two 2-stranded beta-sheets

• 4'-phosphopantetheinyl transferase (56213)

  beta-alpha(3)-beta(2) motif

• DNase I-like (56218)

  contains beta-sandwich; duplication of alpha+beta motif

• Aldehyde ferredoxin oxidoreductase, N-terminal domain (56227)

  contains sandwich; duplication of alpha+beta motif with single mixed sheet
  motif: beta(2)-alpha-beta(3)-alpha-beta; strand order 216345, strands 1 and 6 are parallel

• Ntn hydrolase-like (56234)

  4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing

• DmpA/ArgJ-like (56265)

  duplication of beta(3)-alpha-beta-alpha motif; 4 layers: alpha/beta/beta/alpha

• Pyruvoyl-dependent histidine and arginine decarboxylases (56270)

  duplication of beta-alpha-beta(2) motif; 4 layers: alpha/beta/beta/alpha; contains "silk" beta-sandwich

• S-adenosylmethionine decarboxylase (56275)

  duplication of beta-alpha-beta(4)-alpha-beta-alpha-beta(2) motif; 4 layers a/b/b/a; antiparallel beta-sheets: order 23451687

• Metallo-hydrolase/oxidoreductase (56280)

  duplication of beta(4)-alpha-beta-alpha motif; 4 layers a/b/b/a; mixed beta-sheets

• PP2C-like (81607)

  4 layers: alpha/beta/beta/alpha; antiparallel beta sheets

• Metallo-dependent phosphatases (56299)

  4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication

• Carbon-nitrogen hydrolase (56316)

  4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication

• CNF1/YfiH-like putative cysteine hydrolases (64437)

  4 layers: alpha/beta/beta/alpha; mixed beta sheets

• ADC synthase (56321)

  duplication: contains four repeats of alpha-beta(2)-beta motif arranged in a 4 layer core structure: alpha/beta/beta/alpha; orthogonally packed beta-sheets

• Sulfolobus fructose-1,6-bisphosphatase-like (111248)

  4 layers: a/b/b/a; antiparallel beta sheets; similarities to ferredoxin-like fold (scop_cf 54861) in the N-terminal part (1-120) and to the Bacterial S-adenosylmethionine decarboxylase subunit (scop_fa 997656) in the C-terminal part (121-340)

• LDH C-terminal domain-like (56326)

  unusual fold, defines family

• DNA breaking-rejoining enzymes (56348)

  core: alpha3-beta3-alpha4; one side of beta-sheet is exposed

• Replication modulator SeqA, C-terminal DNA-binding domain (82807)

  consists of seven alpha-helices and three-stranded beta-sheet

• SMAD MH1 domain (56365)

  consists of four alpha-helices and three beta-ribbons

• YopH tyrosine phosphatase N-terminal domain (64448)

  consists of four alpha-helices and two beta-hairpins

• Rotavirus NSP2 fragment, N-terminal domain (75573)

  consists of six alpha-helices and two beta-hairpins

• Ribosome inactivating proteins (RIP) (56370)

  contains mixed beta-sheet

• ADP-ribosylation (56398)

  unusual fold

• Peptide deformylase (56419)

  alpha-beta(5)-alpha; 3 layers: a/b/a; meander beta-sheet wraps around the C-terminal alpha-helix

• LCCL domain (69847)

  unusual fold

• Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (56424)

  unusual fold

• C-type lectin-like (56435)

  unusual fold

• Hemolytic lectin CEL-III, C-terminal domain (111264)

  unusual fold

• SRCR-like (56486)

  unusual fold; disulfide-rich; core: beta-x-alpha-beta-loop-beta

• Fibrinogen C-terminal domain-like (56495)

  unusual fold

• gp120 core (56501)

  unusual fold

• Methionine synthase activation domain-like (56506)

  unusual fold; core: beta-alpha(2)-beta(2)-alpha(2)-beta-alpha-beta; antiparallel beta-sheet: order 12354

• UbiD C-terminal domain-like (143967)

  alpha-beta(2)-alpha-beta-alpha-beta(2); 3 layers, a/b/a; mixed beta-sheet, order: 12354, strands 2,3 and 5 are parallel to each other

• Hypothetical protein TM0875 (90063)

  unusual fold; core: beta(2)-loop-beta(2)-alpha-beta; mixed beta-sheet: order 51243; parallel strands 2 and 4

• Metal cation-transporting ATPase, ATP-binding domain N (81661)

  unusual fold; core: beta-alpha(2)-beta(3)-alpha(2)-beta(2); 6-stranded antiparallel beta-sheet, order: 165432

• Suppressor of Fused, N-terminal domain (103358)

  unusual fold; bifurcated beta-sheet; left-handed beta-alpha-beta unit

• Nitric oxide (NO) synthase oxygenase domain (56511)

  unusual fold

• Penicillin binding protein dimerisation domain (56518)

  unusual fold

• Oxidoreductase molybdopterin-binding domain (56523)

  unusual fold; contains 3 layers of beta-sheet structure and a beta-grasp like motif

• FAH (56528)

  unusual fold; contains 3 layers of beta-sheet structure

• Aromatic aminoacid monoxygenases, catalytic and oligomerization domains (56533)

  unusual fold

• Substrate-binding domain of HMG-CoA reductase (56541)

  unusual fold

• Argininosuccinate synthetase, C-terminal domain (69863)

  unusual fold

• Hypothetical protein PH1602 (103364)

  complex alpha+beta fold; contains a region of similarity to the ferredoxin-like fold

• IlvD/EDD N-terminal domain-like (143974)

  contains a large cluster of helices and a mixed beta-sheet of 4 strands; order 2134, strands 3 and 4 are parallel

• DNA methylase specificity domain (116733)

  comprises the N-terminal, double beta-helix like structure and C-terminal alpha-hairpin

• GCM domain (90072)

  consists of two different alpha+beta subdomains; 2 zinc-binding sites

• Conserved core of transcriptional regulatory protein vp16 (56547)

  unusual fold

• Insert subdomain of RNA polymerase alpha subunit (56552)

  unusual fold; contains a left-handed beta-alpha-beta unit

• Baseplate structural protein gp11 (56557)

  unusual fold; trimer

• Receptor-binding domain of short tail fibre protein gp12 (88873)

  unusual fold; trimer

• Outer capsid protein sigma 3 (64464)

  unusual fold

• Phosphoprotein M1, C-terminal domain (118172)

  consists of 6 helices and one beta-hairpin

• L,D-transpeptidase pre-catalytic domain-like (143984)

  unusual fold, made of four helices and four 2-3 stranded beta-sheets

• YbiA-like (143989)

  consists of six alpha-helices and two two-stranded beta-sheets

• NinB (103369)

  unusual fold; intertwined dimer; consists of two different structural domains

• AF2331-like (143994)

  interlocked dimer of beta-alpha-beta(2)-alpha-beta-(alpha) subunits; 3 layers: b/b/a

• SSo0622-like (111277)

  alpha(2)-beta(2)-alpha-beta-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel beta-sheet: order 21354; strands 1,3 and 5 and the C-terminal helix are longer than other secondary structures

• Putative modulator of DNA gyrase, PmbA/TldD (111282)

  consists of two different alpha+beta domains; d1: [duplication of alpha-beta(3)-alpha motif; 2 layers: a/b; antiparallel beta-sheet, order: 321456; strands 1, 2, 4 and 5 are twice longer than other secondary structures]; d2 [ complex fold; contains beta-barrel (n=5, S=10)]

• Oxysterol-binding protein-like (143999)

  core: large meander beta-sheet of 12 strands wrapped around the N-terminal (distorted) alpha-hairpin; some similarity to transmembrane beta-barrel proteins

• ORC1-binding domain (144004)

  complex fold, composed of an alpha hairpin, meander beta-sheet and a five-stranded barrel of unusual topology

• CofE-like (144009)

  consists of two different domains; d1: beta-alpha-beta-alpha-beta(2)-alpha-beta, mixed sheet of 5 strands, order:15234, strands 2 and 3 are parralel; d2 is inserted in d1 after strand 2 and comprises a helix-turn-helix motif and two 3-stranded sheets

• Peptidoglycan deacetylase N-terminal noncatalytic region (144014)

  consists of two different domains, d1: [alpha-beta(2)-alpha-beta(3); 3 layers: a/b/a; mixed beta-sheet, order 12345, strands 2 and 3 are parallel to each other with a left-handed crossover connection], d2: alpha-beta(3)-alpha; 2 layers; antiparallel beta-sheet, order 123]

• Non-globular alpha+beta subunits of globular proteins (56567)

  not a true fold