pre-SCOP - Superfamily: Thiamin diphosphate-binding fold (THDP-binding) (52518)

Lineage

Root

1.	Class	Alpha and beta proteins (a/b) [51349] (51349)
2.	Fold	Thiamin diphosphate-binding fold (THDP-binding) (52517) 3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily

Thiamin diphosphate-binding fold (THDP-binding) (52518)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
Superfamily

Family Children

Pyruvate oxidase and decarboxylase Pyr module (88724)
the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology
TK-like Pyr module (88735)
different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
Branched-chain alpha-keto acid dehydrogenase Pyr module (88741)
parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
PFOR Pyr module (88746)
domains VI, I and II are arranged in the same way as the TK PP, Pyr and C domains
Pyruvate oxidase and decarboxylase PP module (88749)
the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology
TK-like PP module (88760)
different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
Branched-chain alpha-keto acid dehydrogenase PP module (88766)
parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
PFOR PP module (88771)
domains VI, I and II are arranged in the same way as the TK PP, Pyr and C domains