pre-SCOP - Family: FAD/NAD-linked reductases, N-terminal and central domains (51943)

Lineage

Root

1.	Class	Alpha and beta proteins (a/b) [51349] (51349)
2.	Fold	FAD/NAD(P)-binding domain (51904) core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander
3.	Superfamily	FAD/NAD(P)-binding domain (51905) Superfamily

Family

FAD/NAD-linked reductases, N-terminal and central domains (51943)

duplication: both domains have similar folds and functions
most members of the family contain common C-terminal alpha+beta domain

Protein Children

Glutathione reductase (51944)
Trypanothione reductase (51947)
Mammalian thioredoxin reductase (63947)
Thioredoxin reductase (51950)
lacks the "interface" C-terminal alpha+beta domain
Apoptosis-inducing factor (AIF) (75126)
Alkyl hydroperoxide reductase subunit F (AhpF), C-terminal domains (51953)
NADH peroxidase (51955)
NADH-dependent ferredoxin reductase, BphA4 (51957)
Putidaredoxin reductase (102185)
Dihydrolipoamide dehydrogenase (51959)
NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase (82313)
Flavocytochrome c sulfide dehydrogenase, FCSD, flavin-binding subunit (51966)
has a smaller C-terminal alpha+beta domain instead the "interface" domain
Phenylacetone monooxygenase (110440)
NADH oxidase /nitrite reductase (117442)
Flavin-dependent monoxygenase SPBP16F5.08c (117444)