Lineage

Root

Class

Alpha and beta proteins (a/b) [51349] (51349)

Fold Children

  • TIM beta/alpha-barrel (51350)

    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites

  • YerB-like (995811)

    3 layers: b/b/a; central mixed beta-sheet of 9 strands, order 541329678; strands 3 and 7 are antiparallel to the rest; an unusual "over the other end" connection between strands 3 and 4

  • CdCA1 repeat-like (995805)

    contains two parallel beta-strands of four strands each; the sheets contact each other with edges at a right angle

  • EreA/ChaN-like (995798)

    Core: 3 layers: a/b/a; parallel beta-sheet of 5 strands, order:51423;

  • CobE/GbiG C-terminal domain-like (995779)

    3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32154; strand 5 is antiparallel to the rest

  • AtpF-like (995773)

    3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134

  • NAD(P)-binding Rossmann-fold domains (51734)

    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar

  • FAD/NAD(P)-binding domain (51904)

    core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

  • Nucleotide-binding domain (51970)

    3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like

  • MurCD N-terminal domain (51983)

    3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; incomplete Rossmann-like fold; binds UDP group

  • 7-stranded beta/alpha barrel (51988)

    variant of beta/alpha barrel; parallel beta-sheet barrel, closed, n=7, S=8; strand order 1234567; some members may have fewer strands

  • PFL-like glycyl radical enzymes (51997)

    contains: barrel, closed; n=10, S=10; accommodates a hairpin loop inside the barrel

  • The "swivelling" beta/beta/alpha domain (52008)

    3 layers: b/b/a; the central sheet is parallel, and the other one is antiparallel; there are some variations in topology
    this domain is thought to be mobile in most multi-domain proteins known to contain it

  • Barstar-like (52037)

    2 layers, a/b; parallel beta-sheet of 3 strands, order 123

  • MurF and HprK N-domain-like (63417)

    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1234; structural similarity of the MurF and HprK extends beyond the core.

  • Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) (52046)

    2 curved layers, a/b; parallel beta-sheet; order 1234...N; there are sequence similarities between different superfamilies

  • Ribosomal proteins L15p and L18e (52079)

    core: three turns of irregular (beta-beta-alpha)n superhelix

  • SpoIIaa-like (52086)

    core: 4 turns of a (beta-alpha)n superhelix

  • ClpP/crotonase (52095)

    core: 4 turns of (beta-beta-alpha)n superhelix

  • BRCT domain (52112)

    3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134

  • Lumazine synthase (52120)

    3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134

  • Uracil-DNA glycosylase-like (52140)

    3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134

  • Creatininase (102214)

    3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134

  • DNA polymerase III psi subunit (102219)

    3 layers, a/b/a; parallel beta-sheet of 4 strands, order 2134

  • Initiation factor IF2/eIF5b, domain 3 (52155)

    3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134

  • Aminoacid dehydrogenase-like, N-terminal domain (53222)

    core: 3 layers: a/b/a; parallel beta-sheet of 4 strands; 2134

  • Toprim domain (110454)

    3 layers, a/b/a; parallel beta-sheet of 4 strands, order 2134

  • Ribosomal protein L13 (52160)

    3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 3214

  • Ribosomal protein L4 (52165)

    3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 1423

  • Nqo1 FMN-binding domain-like (142018)

    3 layers, a/b/a; parallel beta-sheet of 4 strands, order 3214

  • Flavodoxin-like (52171)

    3 layers, a/b/a; parallel beta-sheet of 5 strand, order 21345

  • Methylglyoxal synthase-like (52334)

    3 layers, a/b/a; parallel beta-sheet of 5 strands, order 32145

  • Ferredoxin reductase-like, C-terminal NADP-linked domain (52342)

    3 layers, a/b/a; parallel beta-sheet of 5 strands, order 32145

  • Adenine nucleotide alpha hydrolase-like (52373)

    core: 3 layers, a/b/a ; parallel beta-sheet of 5 strands, order 32145

  • Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain (52417)

    3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like

  • Cryptochrome/photolyase, N-terminal domain (52424)

    3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like

  • DsrEFH-like (75168)

    3 layers: a/b/a, core: parallel beta-sheet of 5 strands, order 43215

  • PIN domain-like (88722)

    3 layers, a/b/a; core: parallel beta-sheet of 5 strands, order 32145

  • Ribose/Galactose isomerase RpiB/AlsB (89622)

    3 layers: a/b/a, core: parallel beta-sheet of 5 strands, order 21354; topological similarity to a part of the arginase/deacetylase fold

  • alpha/beta knot (75216)

    core: 3 layers: a/b/a, parallel beta-sheet of 5 strands, order 21435; contains a deep trefoil knot

  • PreATP-grasp domain (52439)

    3 layers: a/b/a; parallel or mixed beta-sheet of 4 to 6 strands
    possible rudiment form of Rossmann-fold domain

  • DHS-like NAD/FAD-binding domain (52466)

    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

  • Tubulin nucleotide-binding domain-like (52489)

    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456

  • Isochorismatase-like hydrolases (52498)

    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456

  • Dipeptide transport protein (63991)

    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; also contains a C-terminal alpha+beta subdomain

  • Homo-oligomeric flavin-containing Cys decarboxylases, HFCD (52506)

    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456

  • HAD-like (56783)

    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456

  • NagB/RpiA/CoA transferase-like (100949)

    core: 3 layers: a/b/a; parallel or mixed beta-sheet of 6 strands, order 321456

  • Hypothetical protein MTH777 (MT0777) (75180)

    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456

  • Thiamin pyrophosphokinase, catalytic domain (63998)

    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 432156

  • Undecaprenyl diphosphate synthase (64004)

    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 342156

  • F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) (102323)

    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213456

  • Thiamin diphosphate-binding fold (THDP-binding) (52517)

    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

  • P-loop containing nucleoside triphosphate hydrolases (52539)

    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

  • PTS IIb component (52727)

    3 layers: a/b/a, parallel beta-sheet of 6 strands, order 324156

  • DNA polymerase III chi subunit (102399)

    3 layers, a/b/a; parallel beta-sheet of 7 strands, order 7165243

  • Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) (52732)

    3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3214567

  • CofD-like (142337)

    3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3214567; topological similarity to the CobT-like fold (scop_cf 52732)

  • MCP/YpsA-like (102404)

    3 layers: a/b/a, parallel beta-sheet of 7 strands, order 4321567

  • Methylesterase CheB, C-terminal domain (52737)

    3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3421567

  • Subtilisin-like (52742)

    3 layers: a/b/a, parallel beta-sheet of 7 strands, order 2314567; left-handed crossover connection between strands 2 & 3

  • Indigoidine synthase A-like (110580)

    core: 3 layers, a/b/a; parallel beta-sheet of 7 strands, order 2134756

  • Arginase/deacetylase (52767)

    3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456

  • Alpha-2,3/8-sialyltransferase CstII (102413)

    3 layers: a/b/a; parallel beta-sheet of 8 strands, order 54321678

  • Cell-division inhibitor MinC, N-terminal domain (64042)

    beta(2)-(alpha-beta)2-beta; 2 layers, a/b; mixed beta-sheet of 5 strands, order 12345; strands 1 & 5 are antiparallel to the rest

  • DTD-like (69499)

    beta(2)-(alpha-beta)2-beta(3); 3 layers, a/b/b; some topological similarity to the N-terminal domain of MinC

  • CoA-dependent acyltransferases (52776)

    core: 2 layers, a/b; mixed beta-sheet of 6 strands, order 324561; strands 3 & 6 are antiparallel to the rest

  • Phosphotyrosine protein phosphatases I-like (52787)

    3 layers: a/b/a; parallel beta-sheet of 4 strands, order 2134

  • (Phosphotyrosine protein) phosphatases II (52798)

    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

  • Rhodanese/Cell cycle control phosphatase (52820)

    3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32451

  • Thioredoxin fold (52832)

    core: 3 layers, a/b/a; mixed beta-sheet of 4 strands, order 4312; strand 3 is antiparallel to the rest

  • Peptidyl-tRNA hydrolase II (102461)

    3 layers: a/b/a; mixed beta-sheet of 4 strands, order 2143, strand 4 is antiparallel to the rest

  • TK C-terminal domain-like (52921)

    3 layers: a/b/a; mixed beta-sheet of 5 strands, order 13245, strand 1 is antiparallel to the rest

  • Pyruvate kinase C-terminal domain-like (52934)

    3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145, strand 5 is antiparallel to the rest

  • Anticodon-binding domain-like (52953)

    3 layers: a/b/a; mixed beta-sheet of five strands, order 21345; strand 4 is antiparallel to the rest

  • MTH938-like (64075)

    core: 3 layers, b+a/b/a ; the central mixed sheet of 5 strands: order 21534; strand 2 is antiparallel to the rest

  • Restriction endonuclease-like (52979)

    core: 3 layers, a/b/a; mixed beta-sheet of 5 strands, order 12345; strands 2 &, in some families, 5 are antiparallel to the rest

  • Resolvase-like (53040)

    Core: 3 layers: a/b/a; mixed beta-sheet of 5 strands, order 21345; strand 5 is antiparallel to the rest

  • PTS system fructose IIA component-like (53061)

    3 layers: a/b/a; mixed beta-sheet of 5 strands, order 21345; strand 5 is antiparallel to the rest

  • Ribonuclease H-like motif (53066)

    3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest

  • Phosphorylase/hydrolase-like (53162)

    core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

  • Molybdenum cofactor biosynthesis proteins (53217)

    3 layers: a/b/a; mixed beta-sheet of 5 strands; order: 21354, strand 5 is antiparallel to the rest; permutation of the Phosphorylase/hydrolase-like fold

  • Bacterial fluorinating enzyme, N-terminal domain (102521)

    3 layers: a/b/a; mixed beta-sheet of 6 strands; order: 213546, strand 5 is antiparallel to the rest; topological similarity to the MogA-like family fold

  • Caspase-like (52128)

    3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest

  • Macro domain-like (52948)

    3 layers: a/b/a; mixed beta-sheet of 6 strands, order 165243, strand 3 is antiparallel to the rest

  • MurD-like peptide ligases, peptide-binding domain (53243)

    3 layers: a/b/a; mixed beta-sheet of 6 strands, order 126345; strand 1 is antiparallel to the rest

  • Phosphoglycerate mutase-like (53253)

    core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 324156; strand 5 is antiparallel to the rest

  • PRTase-like (53270)

    core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest

  • vWA-like (53299)

    core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest

  • Pyruvate-ferredoxin oxidoreductase, PFOR, domain III (53322)

    3 layers: a/b/a; mixed beta-sheet of 6 strands, order 231456; strand 3 is antiparallel to the rest

  • RbsD-like (102545)

    3 layers: a/b/a; mixed beta-sheet of 6 strands, order 251634; strand 6 is antiparallel to the rest

  • FabD/lysophospholipase-like (52150)

    core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 432156; strand 4 is antiparallel to the rest

  • L-sulfolactate dehydrogenase-like (89732)

    core: 3 layers, a/b/a; mixed sheet of 7 strands, order 1237456; strands 1, 6 and 7 are antiparallel to the rest

  • Formyltransferase (53327)

    3 layers: a/b/a; mixed beta-sheet of 7 strands, order 3214567; strand 6 is antiparallel to the rest

  • S-adenosyl-L-methionine-dependent methyltransferases (53334)

    core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

  • LmbE-like (102587)

    3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest; topological similarity to SAM-dependent methyltransferases

  • PLP-dependent transferase-like (53382)

    main domain: 3 layers: a/b/a, mixed beta-sheet of 7 strands, order 3245671; strand 7 is antiparallel to the rest

  • Nucleotide-diphospho-sugar transferases (53447)

    3 layers: a/b/a; mixed beta-sheet of 7 strands, order 3214657; strand 6 is antiparallel to the rest

  • RibA-like (142694)

    3 layers: a/b/a; mixed beta-sheet of 7 strands, order 1235467, strands 1 and 3 are antiparallel to the rest; partial topological similarity to some alpha/beta hydrolases (scop_cf 53473)

  • Activating enzymes of the ubiquitin-like proteins (69571)

    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest

  • alpha/beta-Hydrolases (53473)

    core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

  • Nucleoside hydrolase (53589)

    core: 3 layers, a/b/a ; mixed beta-sheet of 8 strands, order 32145687; strand 7 is antiparallel to the rest

  • Dihydrofolate reductase-like (53596)

    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

  • Ribokinase-like (53612)

    core: 3 layers: a/b/a; mixed beta-sheet of 8 strands, order 21345678, strand 7 is antiparallel to the rest
    potential superfamily: members of this fold have similar functions but different ATP-binding sites

  • YjeF N-terminal domain-like (64152)

    3 layers: a/b/a; mixed (mainly parallel) beta-sheet of 8 strands, order 32145678; strand 8 is antiparallel to the rest

  • Carbamate kinase-like (53632)

    3 layers: a/b/a; mixed (mainly parallel) beta-sheet of 8 strands, order 34215786; strand 8 is antiparallel to the rest

  • 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain (64157)

    core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 45321678, strands 4 and 5 are antiparallel to the rest

  • Alkaline phosphatase-like (53648)

    core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 43516728, strand 7 is antiparallel to the rest

  • TTHA0583/YokD-like (110709)

    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 78612354; strands 3, 4 and 8 are antiparallel to the rest

  • Glycerol-3-phosphate (1)-acyltransferase (69592)

    3 layers: a/b/a; mixed beta-sheet of 9 strands, order 918736452; strands 1, 2 and 8 are antiparallel to the rest

  • AraD/HMP-PK domain-like (53638)

    3 layers: a/b/a; mixed (mostly antiparallel) beta-sheet of 9 strands, order 432159876; left-handed crossover between strands 4 and 5

  • SurE-like (64166)

    3 layers: a/b/a; mixed beta-sheet of 9 strands, order 342156798; strands 3, 8 and 9 are antiparallel to the rest; left-handed crossover connection between strands 6 and 7

  • Isocitrate/Isopropylmalate dehydrogenase-like (53658)

    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

  • Amidase signature (AS) enzymes (75303)

    possible duplication: the topologies of N- and C-terminal halves are similar; 3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213549A867 (A=10); strands from 5 to 9 are antiparallel to the rest

  • ATC-like (53670)

    consists of two similar domains related by pseudo dyad; duplication
    core: 3 layers, a/b/a, parallel beta-sheet of 4 strands, order 2134

  • Tryptophan synthase beta subunit-like PLP-dependent enzymes (53685)

    consists of two similar domains related by pseudo dyad; duplication
    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 3214

  • SIS domain (53696)

    3 layers: a/b/a; parallel beta-sheet of 5 strands, order 21345

  • Formate dehydrogenase/DMSO reductase, domains 1-3 (53705)

    contains of two similar intertwined domains related by pseudo dyad; duplication
    core: 3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32451

  • ALDH-like (53719)

    consists of two similar domains with 3 layers (a/b/a) each; duplication
    core: parallel beta-sheet of 5 strands, order 32145

  • NadA-like (142753)

    duplication; consists of three similar domains related by pseudo threefold symmetry; 3 layers, a/b/a; parallel beta sheet, order: 2134

  • Aconitase iron-sulfur domain (53731)

    consists of three similar domains with 3 layers (a/b/a) each; duplication
    core: parallel beta-sheet of 5 strands, order 32145

  • Phosphoglucomutase, first 3 domains (53737)

    consists of three similar domains with 3 layers (a/b/a) each; duplication
    core: mixed beta-sheet of 4 strands, order 2134, strand 4 is antiparallel to the rest

  • FucI/AraA N-terminal and middle domains (53742)

    consists of two domains of similar topology, 3 layers (a/b/a) each
    Domain 1 (1-173) has parallel beta-sheet of 5 strands, order 21345
    Domain 2 (174-355) has parallel beta-sheet of 4 strands, order 2134

  • YgbK-like (142763)

    consists of two domains with partial topological similarity to the P-loop kinases but without the P-loop motif; the domain association results in the formation of a single mixed beta-sheet of 15 strands

  • Phosphoglycerate kinase (53747)

    consists of two non-similar domains, 3 layers (a/b/a) each
    Domain 1 has parallel beta-sheet of 6 strands, order 342156
    Domain 2 has parallel beta-sheet of 6 strands, order 321456

  • UDP-Glycosyltransferase/glycogen phosphorylase (53755)

    consists of two non-similar domains with 3 layers (a/b/a) each
    domain 1: parallel beta-sheet of 7 strands, order 3214567
    domain 2: parallel beta-sheet of 6 strands, order 321456

  • Glutaminase/Asparaginase (53773)

    consists of two non-similar alpha/beta domains, 3 layers (a/b/a) each
    Domain 1 has mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest; left-handed crossover connection between strands 4 and 5
    Domain 2 has parallel beta-sheet of 4 strands, order 1234

  • Phosphofructokinase (53783)

    consists of two non-similar domains, 3 layers (a/b/a) each
    Domain 1 has mixed sheet of 7 strands, order 3214567; strands 3 & 7 are antiparallel to the rest
    Domain 2 has parallel sheet of 4 strands, order 2314

  • Tetrapyrrole methylase (53789)

    consists of two non-similar domains
    Domain 1 has parallel sheet of 5 strands, order 32415
    Domain 2 has mixed sheet of 5 strands, order 12534; strands 4 & 5 are antiparallel to the rest

  • GckA/TtuD-like (82543)

    consists of two non-similar domains
    Domain 1 has parallel sheet of 6 strands, order 321456, Rossmann-like topology
    Domain 2 has mixed sheet of 6 strands, order 126345; strands 5 and 6 are antiparallel to the rest; some similarity to CbiF Domain 2

  • DAK1/DegV-like (82548)

    2 different domains; d1: [core: 3 layers, a/b/a; parallel sheet of 5 strands, order: 2134]; D2: [2 layers, a/b; mixed sheet of 6 strands, order 321645; strands 2 and 6 are antiparallel to the rest]

  • DHH phosphoesterases (64181)

    consists of two non-similar domains
    Domain 1 has parallel sheet of 6 strands, order 321456
    Domain 2 has mixed sheet of 5 strands, order 12345; strands 1 & 4 are antiparallel to the rest

  • Glycerate kinase I (110737)

    consists of two different alpha/beta domains; (1) of the Flavodoxin-like fold (scop_cf 52171); (2) similar to the Restriction endonuclease-like fold (scop_cf 52979), inserted into domain 1

  • PEP carboxykinase-like (53794)

    contains a P-loop NTP-binding motif; mixed beta-sheet folds into a barrel-like structure with helices packed on one side

  • PEP carboxykinase N-terminal domain (68922)

    contains mixed beta-sheets; topology is partly similar to that of the catalytic C-terminal domain

  • Chelatase-like (53799)

    duplication: tandem repeat of two domains; 3 layers (a/b/a); parallel beta-sheet of 4 strands, order 2134

  • HemD-like (69617)

    duplication: consists of two similar 'swapped' domain with 3 layers (a/b/a) each; parallel beta-sheet of 5 strands, order 21345

  • CAC2185-like (142794)

    consists of two non-similar domains, 3 layers (a/b/a) each; d1 has parallel sheet of 4 strands, order 2134; d2 has parallel sheet of 5 strands, order 21345, and antiparallel meander sheet of 3 strands

  • Periplasmic binding protein-like I (53821)

    consists of two similar intertwined domain with 3 layers (a/b/a) each: duplication
    parallel beta-sheet of 6 strands, order 213456

  • Periplasmic binding protein-like II (53849)

    consists of two similar intertwined domain with 3 layers (a/b/a) each: duplication
    mixed beta-sheet of 5 strands, order 21354; strand 5 is antiparallel to the rest

  • Thiolase-like (53900)

    consists of two similar domains related by pseudo dyad; duplication
    3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32451; strand 5 is antiparallel to the rest

  • NIF3 (NGG1p interacting factor 3)-like (102704)

    consist of two intertwined domains; duplication: contains two structural repeats of alpha-beta-(beta-alpha)3 motif with mixed beta-sheet, order: 1432, strand 1 is antiparallel to the rest

  • Fe-only hydrogenase (53919)

    consist of two intertwined domains; contains partial duplication

  • ComB-like (142822)

    contains of two similar intertwined domains related by pseudo dyad; duplication; core: 3 layers: a/b/a; parallel beta-sheet of 4 strands, order 1423

  • CoA-transferase family III (CaiB/BaiF) (89795)

    consist of two different alpha/beta domains; N-terminal domain has a SurE-like topology with a left-handed beta-alpha-beta unit

  • Cytidine deaminase-like (53926)

    core: alpha-beta(2)-(alpha-beta)2; 3 layers (a/b/a); mixed beta-sheet of 4 strands, order 2134; strand 1 is antiparallel to the rest