- Immunoglobulin-like beta-sandwich (48725)
sandwich; 7 strands in 2 sheets; greek-key
some members of the fold have additional strands
- WSSV envelope protein-like (996307)
beta-sandwich; 9 strands in 2 sheets; greek-key
- Trm112p-like (996298)
similar to the small domain of the ISP (scop_cf 50021)
- YmcC-like (996286)
12-stranded meander beta-sheet, folded into a deformed beta-barrel
- NifT/FixU barrel-like (996280)
barrel, closed, n=6, S=10; meander
- FomD barrel-like (996274)
barrel, closed; n=8, S=12; meander; similar topology to the AOC barrel-like fold (reversed to the lipocalin barrel topology)
- Spiral beta-roll (996268)
a large 15-stranded beta-sheet rolled about a single helix core; overlapping edges form a sandwich-like structure
- YopT-like (996262)
beta-sheet barrel, closed, n=6, S=12, capped at both ends by helices; intertwined dimer of beta-alpha-beta(2) subinits;
- YopX-like (996256)
consists of two domains: the N-terminal dimerisation domain of variable structure and the C-terminal domain with similarity to the SH3-like fold
- AttH-like (996244)
duplication: two flattened beta-barrels of lipocalin-like topology are orthogonally packed with a pseudo twofold symmetry
- Common fold of diphtheria toxin/transcription factors/cytochrome f (49379)
sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold
- Prealbumin-like (49451)
sandwich; 7 strands in 2 sheets, greek-key
variations: some members have additional 1-2 strands to common fold
- HSP40/DnaJ peptide-binding domain (49492)
sandwich; 6 strands in 2 sheets
- Penicillin-binding protein associated domain (69188)
sandwich; 6 strands in 2 sheets
- alpha-Amylase inhibitor tendamistat (49497)
sandwich; 6 strands in 2 sheets
- C-terminal domain of mollusc hemocyanin (81278)
six-stranded beta-sandwich, jelly-roll/greek-key topology
- HPA-like (141085)
sandwich, 6 strands in 2 sheets; jelly-roll (truncated); also includes the pending PCSK9 V domain-like superfamily (the C-terminal domains of 2p4e and 2pmw)
- L21p-like (141090)
core: sandwich, 6 strands in 2 sheets
- Cupredoxin-like (49502)
sandwich; 7 strands in 2 sheets, greek-key
variations: some members have additional 1-2 strands
- Ctag/Cox11 (110110)
sandwich; 7 strands in 2 sheets, greek-key; permutation of the immunoglobulin-like fold
- Atu1913-like (141098)
sandwich; 7 strands in two sheets, greek-key/jelly-roll; forms segment swapped dimers, swapping is probably facilitated by the helix insertion after strand 3
- C2 domain-like (49561)
sandwich; 8 strands in 2 sheets; greek-key
- TRAF domain-like (49598)
sandwich; 8 strands in 2 sheets; greek-key
- Neurophysin II (49605)
sandwich; 8 strands in 2 sheets; meander
- N-utilization substance G protein NusG, insert domain (82003)
sandwich; 8 strands in 2 sheets; meander
- Nucleoplasmin-like/VP (viral coat and capsid proteins) (88632)
sandwich; 8 strands in 2 sheets; jelly-roll; some members can have additional 1-2 strands
characteristic interaction between the domains of this fold allows the formation of five-fold and pseudo six-fold assemblies
- gamma-Crystallin-like (49694)
sandwich; 8 strands in 2 sheets; greek-key
duplication: has internal pseudo twofold symmetry
- Lipase/lipooxygenase domain (PLAT/LH2 domain) (49722)
sandwich; 8 strands in 2 sheets; complex topology
duplication: has weak internal pseudo twofold symmetry
- Calpain large subunit, middle domain (domain III) (49757)
sandwich; 8 strands in 2 sheets; jelly-roll
- Supernatant protein factor (SPF), C-terminal domain (101575)
sandwich; 8 strands in 2 sheets; jelly-roll; similarity to the Nucleoplasmin-like/VP fold
- Hypothetical protein TM1070 (89231)
sandwich; 8 strands in 2 sheets; jelly-roll
- Olfactory marker protein (63696)
sandwich; 8 strands in 2 sheets; jelly-roll
- HSP20-like chaperones (49763)
sandwich; 8 strands in 2 sheets; greek-key
- Heat shock protein 70kD (HSP70), peptide-binding domain (100919)
beta-sandwich: 8 strands in 2 sheets
- Ecotin, trypsin inhibitor (49771)
sandwich; 8 strands in 2 sheets; complex topology with the crossing loops
- PEBP-like (49776)
sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
- Ganglioside M2 (gm2) activator (63706)
sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
- Nicotinic receptor ligand binding domain-like (63711)
sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
- Beta-galactosidase LacA, domain 3 (117099)
sandwich; 8 strands in 2 sheets
- Galactose-binding domain-like (49784)
sandwich; 9 strands in 2 sheets; jelly-roll
- Viral protein domain (49817)
sandwich; 9 strands in 2 sheets; jelly-roll; form trimers
- Calcium-mediated lectin (82025)
sandwich; 9 strands in 2 sheets; greek-key
- Dextranase, N-terminal domain (101595)
sandwich; 9 strands in 2 sheets; greek-key
- Unnamed hypothetical protein (101600)
sandwich; 9 strands in 2 sheets; greek-key/jelly-roll
- Superantigen (mitogen) Ypm (101605)
sandwich; 9 strands in 2 sheets; jelly-roll
- ENV polyprotein, receptor-binding domain (49829)
sandwich; 9 strands in 2 sheets; greek-key; contains a few helices in loop regions
- BTV NS2-like ssRNA-binding domain (110131)
sandwich; 9 strands in 2 sheets; unusual topology with 2 crossover loops
- Virus attachment protein globular domain (49834)
sandwich, 10 strands in 2 sheets; greek-key
- TNF-like (49841)
sandwich, 10 strands in 2 sheets; jelly-roll
- CUB-like (49853)
sandwich, 10 strands in 2 sheets; jelly-roll
- Hyaluronate lyase-like, C-terminal domain (49862)
sandwich, 10 strands in 2 sheets; "folded meander"
- Cytolysin/lectin (63723)
sandwich, 10 strands in 2 sheets;
- Putative glucosidase YicI, C-terminal domain (117124)
sandwich; 10 strands in two sheets
- CsrA-like (117129)
sandwich; 10 strands in 2 sheets; intertwined dimer (segment-swapped, 5-stranded greek-key sandwich?)
- Osmotin, thaumatin-like protein (49869)
sandwich; 11 strands in 2 sheets
- SMAD/FHA domain (49878)
sandwich; 11 strands in 2 sheets; greek-key
- Soluble secreted chemokine inhibitor, VCCI (49888)
sandwich; 11 strands in 2 sheets; greek-key
- Baculovirus p35 protein (49893)
sandwich; 14 strands in 2 sheets; greek-key
- Concanavalin A-like lectins/glucanases (49898)
sandwich; 12-14 strands in 2 sheets; complex topology
- Supersandwich (49993)
sandwich; 18 strands in 2 sheets
- Leukotriene A4 hydrolase N-terminal domain (63736)
duplication: two beta-sandwiches of similar topologies are fused together in a single three beta-sheet domain
- EV matrix protein (50011)
consists of two beta-sandwich domains of similar topologies
- Viral chemokine binding protein m3 (82045)
consists of two different beta-sandwich domains of partial topological similarity to immunoglobulin-like folds
- gp9 (50016)
consists of two different beta-sandwich domains unrelated to other beta-sandwich folds
- Flagellar hook protein flgE (117142)
consists of two different domains; d1: [complex fold made of bifurcated beta-sheets]; d2 (inserted into d1): [beta-sandwich; 8 strands in 2 sheets]
- ISP domain (50021)
consists of two all-beta subdomains: conserved small domain has a rubredoxin-like fold; larger domain consists of 6 beta-stands packed in either sandwich of two 3-stranded sheets or closed barrel (n=6; S=8)
- Obg-fold (82050)
this fold is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich
these regions form six left-handed collagen-like helices packed and H-bonded together
- SH3-like barrel (50036)
barrel, partly opened; n*=4, S*=8; meander
the last strand is interrupted by a turn of 3-10 helix
- GroES-like (50128)
contains barrel, partly opened; n*=4, S*=8; meander
- PDZ domain-like (50155)
contains barrel, partly opened; n*=4, S*=8; meander; capped by alpha-helix
- N-terminal domains of the minor coat protein g3p (50175)
core: barrel, in some members open; n*=4, S*=8; meander
- Sm-like fold (50181)
core: barrel, open; n*=4, S*=8; meander; SH3-like topology
- SspB-like (101737)
core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
- Rof/RNase P subunit-like (101743)
core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
- Hydrophobin II, HfbII (101750)
core: barrel, closed; n=4, S=8; complex topology; helix-containing crossover connection
- Ribosomal protein L14 (50192)
barrel, closed; n=5, S=8, meander
- OB-fold (50198)
barrel, closed or partly opened n=5, S=10 or S=8; greek-key
- PRC-barrel domain (50345)
core: barrel, partly opened; n*=5, S*=8; meander
- beta-Trefoil (50352)
barrel, closed; n=6, S=12; and a hairpin triplet; meander
duplication: has internal pseudo threefold symmetry
- Reductase/isomerase/elongation factor common domain (50412)
barrel, closed; n=6, S=10; greek-key
- Elongation factor/aminomethyltransferase common domain (50464)
barrel, closed; n=6, S=10; greek-key
- Split barrel-like (50474)
barrel; n=6, S=10; greek-key
- Phage tail proteins (69278)
core: barrel; n=6, S=10; greek-key; topologically similar to the FMN-binding split barrel
- Surface presentation of antigens (SPOA) (101800)
segment-swapped dimer forming two identical conjoint barrels (n=6, S=10) topologically similar to the FMN-binding split barrel
- FMT C-terminal domain-like (50485)
barrel, open; n*=6, S*=10; greek-key
- Trypsin-like serine proteases (50493)
barrel, closed; n=6, S=8; greek-key
duplication: consists of two domains of the same fold
- Replicase NSP9 (101815)
barrel; n=6, S=8, greek-key; similar to one trypsin-like protease barrel
- mu transposase, C-terminal domain (50609)
barrel; n=6, S=8, greek-key
- Domain of alpha and beta subunits of F1 ATP synthase-like (50614)
barrel, closed; n=6, S=8; greek-key
- Small protein B (SmpB) (74981)
barrel, closed; n=6, S=8, greek-key, partial similarity to the OB-fold
- Acid proteases (50629)
barrel, closed; n=6, S=10, complex topology
- ValRS/IleRS/LeuRS editing domain (50676)
core: barrel, closed; n=6, S=8; topology is similar to that of the acid proteases barrel
- Urease metallochaperone UreE, N-terminal domain (69286)
barrel, closed; n=6, S=8; a crossover loop topology
- Double psi beta-barrel (50684)
barrel, closed; n=6, S=10; complex topology with crossover (psi) loops
- Ribosomal protein L25-like (50714)
barrel, closed; n=6, S=10; complex topology
- Core binding factor beta, CBF (50722)
barrel, closed; n=6, S=10; meander; capped at both ends by alpha-helices
- PH domain-like barrel (50728)
barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
- Transcription factor IIA (TFIIA), beta-barrel domain (50783)
barrel, closed; n=6, S=12; mixed beta-sheet
- Hcp1-like (141451)
barrel, closed; n=6, S=12; contains extra, non-barrel strand 7 at the C-terminus
- Herpes virus serine proteinase, assemblin (50788)
core: barrel, closed; n=7, S=8; complex topology
- PK beta-barrel domain-like (50799)
barrel, closed; n=7, S=10; complex topology
- XRCC4, N-terminal domain (50808)
barrel, closed; n=7, S=10; order: 1234765; strands 1 and 5 are parallel to each other
- HesB-like domain (89359)
barrel, closed; n=7, S=10; complex topology
- Bacterial fluorinating enzyme, C-terminal domain (101851)
barrel, closed; n=7, S=10; greek-key topology; one overside connection
- SPOC domain-like (100938)
barrel, closed; n=7, S=10; complex topology
- BH3618-like (141456)
barrel, closed; n=7, S=10; meander
- FAS1 domain (82152)
core: barrel, closed; n=7, S=12; meander
- Lipocalins (50813)
barrel, closed or opened; n=8, S=12; meander
- Streptavidin-like (50875)
barrel, closed; n=8, S=10; meander
- AOC barrel-like (141492)
barrel, closed; n=8, S=10; meander; mirrored (reversed) topology to the Spreptavidin-like and Lipocalin-like folds
- Cyclophilin-like (50890)
barrel, closed; n=8, S=10; complex topology
- Oncogene products (50903)
barrel, closed; n=8, S=10; one overside connection
- L,D-transpeptidase catalytic domain-like (141522)
barrel, closed; n=8, S=10; one overside connection
- Sortase (63816)
barrel, closed; n=8, S=10; mixed sheet; two overside connections
- PTSIIA/GutA-like (141529)
barrel, closed; n=8, S=12; mixed sheet; two overside connections; duplication: consists of two intertwinned structural repeats
- Mannose 6-phosphate receptor domain (50910)
barrel, partly open; n*=8, S*=10; one psi loop
- triple barrel (50915)
dimer of two non-identical subunits; forms two similar barrels, n=8, S=10 each, that are fused together with the formation of third barrel, n=6, S=8
- 4-bladed beta-propeller (50922)
consists of four 4-stranded beta-sheet motifs; meander
- 5-bladed beta-propeller (50933)
consists of five 4-stranded beta-sheet motifs; meander
- 6-bladed beta-propeller (50938)
consists of six 4-stranded beta-sheet motifs; meander
- 7-bladed beta-propeller (50964)
consists of seven 4-stranded beta-sheet motifs; meander
- 8-bladed beta-propeller (50997)
consists of eight 4-stranded beta-sheet motifs; meander
also found in some members of the WD40-repeat superfamily
- Glycosyl hydrolase domain (51010)
folded sheet; greek-key
- WW domain-like (51044)
core: 3-stranded meander beta-sheet
- Head domain of nucleotide exchange factor GrpE (51063)
small mixed beta-sheet, 4 "generalized" strands
- Coronavirus RNA-binding domain (110303)
coiled antiparallel beta-sheet of 5 strands, order 51324; complex topology, crossing loops
- Ribonuclease domain of colicin E3 (63839)
twisted meander beta-sheet of 6 strands
- NAC domain (101940)
core: twisted 7-stranded beta-sheet (half-barrel)
- At5g01610-like (141561)
contains large meander beta-sheet bent into a scoop-like shape
- Carbonic anhydrase (51068)
single sheet; 10 strands
- Prokaryotic lipoproteins and lipoprotein localization factors (89391)
11 stranded sheet partly folded in a corner-like structure filled with a few short helices
- Bacteriochlorophyll A protein (51080)
single sheet; 16 strands; meander
- open-sided beta-meander (51086)
single sheet formed by beta-hairpin repeats; exposed on both sides in the middle
- beta-Prism I (51091)
consists of 3 4-stranded sheets; strands are parallel to the 3-fold axis
duplication: has internal pseudo threefold symmetry
- beta-Prism II (51109)
consists of 3 4-stranded sheets; strands are perpendicular to the 3-fold axis
duplication: consists of two domains of this fold
- Single-stranded right-handed beta-helix (51125)
superhelix turns are made of parallel beta-strands and (short) turns
- Single-stranded left-handed beta-helix (51160)
superhelix turns are made of parallel beta-strands and (short) turns
- Double-stranded beta-helix (51181)
one turn of helix is made by two pairs of antiparallel strands linked with short turns
has appearance of a sandwich of distinct architecture and jelly-roll topology
- Triple-stranded beta-helix (69348)
(homo)trimer; each chain donates 3 beta-strands per turn of the helix
- Triple beta-spiral (51224)
trimer formed by the interlocking beta-hairpin repeat units
- Trimeric adhesin (101998)
trimer; contains two different beta-prism-like domains connected by an linker subdomain of less regular structure
- beta-hairpin stack (69359)
Trp-rich beta-hairpin repeat units form helical structures of 3 units per turn
- Barrel-sandwich hybrid (51229)
sandwich of half-barrel shaped beta-sheets
- beta-clip (51268)
double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll
- PheT/TilS domain (56036)
core: 3 layers; contains beta-sandwich of unusual topology
- C-terminal autoproteolytic domain of nucleoporin nup98 (82214)
multisheet protein with a mixture of beta-sandwich and beta-prism features
- Pseudo beta-prism (141657)
beta-sandwich with one regular beta-sheet and the other beta-sheet bent in the middle with a set of aligned beta-bulges
- SARS ORF9b-like (141665)
complex dimeric fold with three intersubunit beta-sheets packed around a single core
- Adsorption protein p2 (89427)
multisheet protein containing partial beta-propeller and beta-sandwich regions
- Baseplate structural protein gp8 (89432)
multisheet protein with a mixture of beta-sandwich and beta-barrel features
- Hedgehog/intein (Hint) domain (51293)
complex fold made of five beta-hairpin units and a b-ribbon arc
- LexA/Signal peptidase (51305)
complex fold made of several coiled beta-sheets; contains an SH3-like barrel
- Cloacin translocation domain (69368)
complex fold made of several coiled beta-sheets
- Mss4-like (51315)
complex fold made of several coiled beta-sheets
- Cyanovirin-N (51321)
complex fold
- Tp47 lipoprotein, N-terminal domain (82219)
complex fold; consists of two intertwined subdomains
- Methuselah ectodomain (63876)
complex fold
- Head-binding domain of phage P22 tailspike protein (51326)
complex fold made of bifurcated and partly folded beta-sheet
- E2 regulatory, transactivation domain (51331)
complex fold made of bifurcated and coiled beta-sheets
- MoeA N-terminal region -like (63881)
complex fold made of bifurcated and coiled b-sheets
- MOSC N-terminal domain-like (141672)
complex fold; comprises a beta-hairpin and a meander 3-stranded sheet packed against beta-barrel: closed, n=5, S=8; contains three short helices
- MAL13P1.257-like (141677)
complex fold; duplication: consists of two intertwinned structural repeats related by pseudo dyad
- Composite domain of metallo-dependent hydrolases (51337)
pseudobarrel; mixed sheet of 7 strand folded upon itself and "buckled" by two beta-turns
- Epsilon subunit of F1F0-ATP synthase N-terminal domain (51343)
pseudobarrel: sandwich of two sheets packed at a positive interstrand angle and interconnected with many short turns
- N-terminal domain of MutM-like DNA repair proteins (81625)
pseudobarrel; capped on both ends by alpha-helices
- Hypothetical protein YojF (89441)
pseudobarrel; capped at one end by an alpha-helix
- DNA-binding pseudobarrel domain (101935)
core: barrel, open; n=7, S*=10; capped with helices at both ends; partial similarity to the AbrB/MazE/MraZ-like fold (scop_cf 89446)
- Double-split beta-barrel (89446)
pseudobarrel; capped on both ends by alpha-helices
- PUA domain-like (88696)
pseudobarrel; mixed folded sheet of 5 strands; order 13452; strand 1 and 3 are parallel to each other
- AXH domain (102030)
pseudobarrel; some similarity to OB-fold
- FimD N-terminal domain-like (141728)
pseudo barrel, capped by an alpha-helix; some topological similarity to the PRC-barrel domain (scop_sf 50346) and the N-terminal domain of Glutamine synthetase (scop_sf 54368)
- HisI-like (141733)
pseudo barrel, capped by an alpha-helix; contains a beta-triangle structure on one side; some topological similarity to the Ribosomal protein L25-like fold (scop_cf 50714) and the N-terminal domain of Glutamine synthetase (scop_sf 54368)
- MFPT repeat-like (141738)
consists of two similar pseudo barrel subdomains with structural similarity to a circularly permuted SAND domain (scop_fa 63764)
- P-domain of calnexin/calreticulin (63886)
non-globular proline-rich hairpin