- Biotin repressor-like (46786)
- LexA repressor, N-terminal DNA-binding domain (46789)
- Arginine repressor (ArgR), N-terminal DNA-binding domain (46792)
- Transcriptional repressor Rex, N-terminal domain (101007)
- CAP C-terminal domain-like (46796)
- Lrp/AsnC-like transcriptional regulator N-terminal domain (68967)
Swapped dimer with the "wing" C-terminal strands
- ArsR-like transcriptional regulators (46801)
The N- and C-terminal helical extensions to the common fold form the dimer interface
- Transcriptional regulator IclR, N-terminal domain (74676)
- MarR-like transcriptional regulators (63379)
The N- and C-terminal helical extensions to the common fold form the dimer interface
- DNA-binding protein Mj223 (81690)
homologous to the MarR-like family in the DNA-binding region but dimerizes differently through the N- and C-terminal helical extensions to the common fold
- Penicillinase repressor (101016)
homologous to the MarR-like family in the DNA-binding region but has a different dimerisation subdomain
- GntR-like transcriptional regulators (46804)
- N-terminal domain of Bacillus PurR (101021)
- Replication terminator protein (RTP) (46807)
- LysR-like transcriptional regulators (88979)
contains long helix in the C-terminal extension; forms dimer similar to the RTP dimer
- N-terminal domain of molybdate-dependent transcriptional regulator ModE (46810)
contains beta-hairpin in the N-terminal extension and two helices in the C-terminal extension
- Transcription factor MotA, activation domain (46813)
The N- and C-terminal helical extensions to the common fold form the dimer interface (distinct from that of ArsR-like family)
- Transcription factor E/IIe-alpha, N-terminal domain (101024)
contains extra N-terminal helix
- FUR-like (101027)
contains extra N-terminal helix and an alpha+beta dimerisation subdomain
- Replication initiation protein (46816)
duplication: tandem repeat of two "winged helix" domains arranged with the pseudo twofold symmetry
- Helicase DNA-binding domain (46819)
follows the extended AAA-ATPase domain
- RecQ helicase DNA-binding domain-like (101030)
follows the tandem AAA-ATPase domain
- SCF ubiquitin ligase complex WHB domain (74679)
- C-terminal fragment of elongation factor SelB (74683)
- Restriction endonuclease FokI, N-terminal (recognition) domain (46824)
- TnsA endonuclease, C-terminal domain (46782)
- Plant O-methyltransferase, N-terminal domain (63475)
unknown function
- Linker histone H1/H5 (46827)
- Forkhead DNA-binding domain (46832)
- DNA-binding domain from rap30 (46841)
- C-terminal domain of the rap74 subunit of TFIIF (63480)
- C-terminal domain of RPA32 (46844)
- DEP domain (63483)
membrane-binding domain
- Cell cycle transcription factor e2f-dp (46847)
heterodimer of two homologous chains
- The central core domain of TFIIE beta (46850)
- Z-DNA binding domain (46853)
Pfam 02295
- P4 origin-binding domain-like (46856)
C-terminus passes through the first loop
- ets domain (46859)
- Heat-shock transcription factor (46873)
- Interferon regulatory factor (46877)
Pfam 00605
- 39 kda initiator binding protein, IBP39, N-terminal domain (101045)
- Iron-dependent repressor protein (46882)
- Dissimilatory sulfite reductase DsvD (101048)
- La domain (101051)
Pfam 05383; RNA-binding domain
- Methionine aminopeptidase, insert domain (46887)
circularly permuted version of the "winged helix" fold
- PCI domain (PINT motif) (109671)
Pfam 01399
- F93-like (109674)
contains long helix in the C-terminal extension; forms dimer similar to the RTP and LysR dimers
- Archaeal DNA-binding protein (109677)
contains long helix in the C-terminal extension; forms dimer similar to the RTP and LysR dimers
- TrmB-like (109680)
The N- and C-terminal helical extensions to the common fold form the dimer interface, distinct from other known families
- Heat-inducible transcription repressor HrcA, N-terminal domain (109683)
similar domain organization to the transcriptional regulator IclR
- DNA replication factor Cdt1 (109686)
- Eukaryotic translation initiation factor 3 subunit 12, eIF3k, C-terminal domain (109689)
C-terminal part of Pfam 06272
- Vacuolar sorting protein domain (109692)
duplication: tandem repeat of two "winged-helix" domains
- Transcriptional regulator Rrf2 (109699)
Pfam 02082
- Rio2 serine protein kinase N-terminal domain (109702)
- Rad21/Rec8-like (116795)
Pfam 04824
- Hypothetical protein PH1932 (116798)
contains new dimerisation all-alpha C-terminal subdomain
- An Obfc1 domain (116801)
helix-loop insertion in the HTH motif
- ScpB/YpuH-like (116804)
Pfam 04079
duplication: tandem repeat of two 'winged helix' domains; forms a dimer via the C-terminal domain
- PadR-like (116807)
Pfam 03551; related to the MarR-like family (Pfam 01047)
- Hypothetical protein YhgG (116812)
- ROK associated domain (140279)
found N-terminal to ROK domain in some proteins
- PF1790-like (140286)
sequence similarity to PH1932 in the N-terminal domain; the C-terminal domain provides new dimerisation interface made of a beta-hairpin and a coiled coil
- MukF N-terminal domain-like (140289)
N-terminal part of Pfam 03882
- CodY HTH domain (140292)
Pfam 08222
- FtsK C-terminal domain-like (140295)
PfamB 000224
- Nudix-associated domain (140299)
PfamB 002148; this domain is C-terminal to the Nudix domain in some bacterial proteins
- HxlR-like (140304)
Pfam 01638; DUF24; the N- and C-terminal helical extensions to the common fold form the dimer interface similar to that of the ArsR-like family (scop_fa 46801)
- Marine metagenome family WH1 (997678)
- ReutB4095-like (997674)
probable biological unit is a homohexamer
- PH0730 N-terminal domain-like (997670)
- FaeA-like (997666)
Pfam 04703
- STY4665 C-terminal domain-like (997662)
Pfam 07515; DUF1528; the "wing" hairpin, linker between helices 1 and 2 and the C-terminal tail together form an open beta-sheet barrel
- PSPTO2686-like (997658)
Pfam 04337; DUF480; duplication: two "winged helix" domains are tightly packed "back-to-back" about pseudo twofold axis
- RHA1_ro06458-like (997653)
- YjcQ-like (997649)
Pfam 09639
- F112-like (997645)
- MerB N-terminal domain-like (997641)
- CED-4 C-terminal domain-like (997637)
similar domain architecture to AAA+ helicases
- ELL N2 domain-like (997633)
PfamB 026212; includes recent PDB entry 2e5n
- PF0610-like (997629)
PfamB 016993; insertion of a zinc-ribbon subdomain in the beta-hairpin "wing"
- Rv2827c N-terminal domain-like (997625)
~80 N-terminal residues of Pfam 09407' DUF2005
- Rps19E-like (997621)
Pfam 01090; local sequence similarity to members of the GntR-like family
- RPO3F domain-like (997617)
middle region of Pfam 05158