Fold Children

• Globin-like (46457)

  core: 6 helices; folded leaf, partly opened

• HAMP domain-like (998308)

  dimer of helix-loop-helix segments; distict from the HLH-like fold; parallel four-helical bundle with two overside connections

• HP0242-like (998302)

  multihelical; intertwined homodimer of four-helical subunits, forming catenated triangular ring-like structures; pseudo knot

• SOCS box-like (998295)

  helix-loop-helix motif with orthogonally packed helices

• YqgQ-like (998286)

  3 helices, bunble, left-handed twist, extended overside connection between the first and second helices

• DnaD domain-like (998280)

  4 helices; bundle, right-handed twist; left-handed superhelix

• GINS helical bundle-like (998274)

  5 helices, staggered bundle;

• YejL-like (998254)

  6 helices; intertwined homodimer of three-helical subunits, bundle

• RbcX-like (998236)

  5 helices per subunit; irregular array of short and long helices; swapping of the C-terminal helices in the dimer

• BH2638-like (998223)

  4 helices, folded leaf, right-handed superhelix; some similarity to the DFF-C domain fold (scop_cf 81782)

• SMc04008-like (998217)

  multihelcal; intertwined homodimer; there are 4 core helices in each subunits

• YheA-like (998211)

  5 helices; "kinked" antiparallel coiled coil; forms flexible oligomeric assemblies via two different dimerisation interfaces

• UraD-like (998195)

  multihelical; irregular array of long and short helices

• Sec63 N-terminal domain-like (998184)

  multihelical; consists of two helical subdomains

• MG296-like (998174)

  multihelical; in crystal forms helical polymers by swapping the two N-terminal helices to the next subunit in polymer; three subunits per turn of polymer helix

• Tex N-terminal region-like (998168)

  multihelical; irregular array of long and short helices; can be divided into several subdomains

• Jann4075-like (998161)

  core: 5 helices; the C-terminal helix is surrounded by the others; similarity to some EF-hand domains

• AGR_C_984p-like (998155)

  multihelical, consists of two subdomains; duplication: there are two 5-helical structural repeats, one in each subdomain

• TerB-like (998149)

  multihelical; contains two central helices; duplication: there are two three-helical repeats related by pseudo twofold symmetry

• PSPTO4464-like (998139)

  multihelical; consists of two subdomains at the ends of a long connecting helix

• RPA2825-like (998133)

  5 helices, array; long flexible loop between helices 1 and 2; the remaining helices are arranged similar to the PGBD-like fold (scop_cf 47089)

• Sama2622-like (998127)

  core: 6 helices; bundle; one central helix is surrounded by 5 others

• TAFH domain-like (998121)

  5 helices; folded leaf, closed

• ENT-like (998111)

  5 helices, irregular array, right-handed superhelix

• PMT central region-like (998104)

  multihelical; comprises two four-helical bundles of different topologies and an irregular helical array packed against a small beta-sheet

• MtlR-like (998096)

  multihelical; 8-helical up-and-down bundle

• Orange domain-like (998085)

  4 helices; dimer of identical alpha-hairpin subunits;

• Long alpha-hairpin (46556)

  2 helices; antiparallel hairpin, left-handed twist

• Type I dockerin domain (63445)

  tandem repeat of two calcium-binding loop-helix motifs, distinct from the EF-hand

• LEM/SAP HeH motif (63450)

  helix-extended loop-helix; parallel helices

• RPB6/omega subunit-like (63561)

  core: 2 helices and adjacent loops

• KRAB domain (Kruppel-associated box) (109639)

  2 helices: one short, one long; aromatic-rich iterface

• Cytochrome c (46625)

  core: 3 helices; folded leaf, opened

• DNA/RNA-binding 3-helical bundle (46688)

  core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down

• Another 3-helical bundle (81602)

  topologically similar to the DNA/RNA-binding bundles; distinct packing

• RuvA C-terminal domain-like (46928)

  3 helices; bundle, right-handed twist

• S13-like H2TH domain (81297)

  core: 3-4 helices

• Putative DNA-binding domain (46954)

  core: 3 helices; architecture is similar to that of the "winged helix" fold but topology is different

• Spectrin repeat-like (46965)

  3 helices; bundle, closed, left-handed twist; up-and-down

• immunoglobulin/albumin-binding domain-like (46996)

  3 helices; bundle, closed, left-handed twist; up-and-down; mirror topology to the spectrin-like fold

• Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex (47004)

  3 helices; bundle, closed, right-handed twist; up-and-down

• ChaB-like (140375)

  3 helices, the first one is shorter than the other two; bundle, capped by a small, C-terminal beta-hairpin

• Protozoan pheromone-like (47013)

  3 helices; bundle, closed, left-handed twist, up-and-down

• Acyl-CoA binding protein-like (47026)

  core: 3 helices; bundle, closed, left-handed twist; up-and-down

• Kix domain of CBP (creb binding protein) (47039)

  3 helices; bundle, partly opened

• RAP domain-like (47044)

  3 helices, the first one is shorter than the other two; bundle, partly opened

• VHP, Villin headpiece domain (47049)

  3 short helices; irregular array

• BSD domain-like (140382)

  core: 3 helices; triangular array; the extra N-terminal and C-terminal helices form a coiled coil structure

• TAF(II)230 TBP-binding fragment (47054)

  3 short helices; irregular array

• S15/NS1 RNA-binding domain (47059)

  3 helices; irregular array

• Frizzled cysteine-rich domain (63500)

  Core: 3 helices; irregular array; disulfide-rich

• T4 endonuclease V (47076)

  3 helices; irregular array

• Fertilization protein (47081)

  core: 3 helices; bundle, closed, right-handed twist; up-and-down

• PGBD-like (47089)

  core: 3 helices; bundle, closed, left-handed twist; parallel

• HMG-box (47094)

  3 helices; irregular array

• Histone-fold (47112)

  core: 3 helices; long middle helix is flanked at each end with shorter ones

• Open three-helical up-and-down bundle (47143)

  core: 3 helices; bundle, open

• beta-catenin-interacting protein ICAT (81729)

  core: 3 helices; irregular array

• DNA polymerase III theta subunit-like (116730)

  3 helices; irregular array

• Four-helical up-and-down bundle (47161)

  core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

• PTS-regulatory domain, PRD (63519)

  core: 4 helices; bundle, closed, right-handed twist; 1 crossover connection

• Ferritin-like (47239)

  core: 4 helices; bundle, closed, left-handed twist; 1 crossover connection

• 4-helical cytokines (47265)

  core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

• Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases (47322)

  core: 4 helices; bundle; one loop crosses over one side of the bundle

• Acyl carrier protein-like (47335)

  4 helices, bundle; helix 3 is shorter than others; up-and-down

• Bromodomain-like (47363)

  4 helices; bundle; minor mirror variant of up-and-down topology

• ROP-like (47379)

  4 helices; dimer of identical alpha-hairpin subunits; bundle, closed, left-handed twist

• Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit (47390)

  4 helices; bundle, closed, right-handed twist

• Soluble domain of poliovirus core protein 3a (89042)

  4 helices; bundle, closed, right-handed twist

• Transcription factor IIA (TFIIA), alpha-helical domain (47395)

  4 helices; bundle, closed, right-handed twist

• Ectatomin subunits (47400)

  4 helices; bundle, closed, left-handed twist

• Dimerisation interlock (47405)

  4 helices; bundle, closed, right-handed twist

• lambda repressor-like DNA-binding domains (47412)

  core: 4 helices; folded leaf, closed

• Signal peptide-binding domain (47445)

  4 helices; orthogonal array

• A DNA-binding domain in eukaryotic transcription factors (47453)

  4 helices; the long C-terminal helix protrudes from the domain and binds to DNA

• HLH-like (47458)

  4-helices; bundle, closed, left-handed twist; 2 crossover connections

• EF Hand-like (47472)

  core: 4 helices; array of 2 hairpins, opened

• CH domain-like (47575)

  core: 4 helices: bundle

• Domain of poly(ADP-ribose) polymerase (47586)

  core: 4 helices: bundle; unusual topology

• SWIB/MDM2 domain (47591)

  core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
  duplication: consists of two structural repeats

• Pre-protein crosslinking domain of SecA (81766)

  core: 4 helices: bundle; flanked by two short beta-hairpins
  duplication: consists of two structural repeats

• Ribbon-helix-helix (47597)

  core: 4 helices; array of 2 hairpins, opened

• GST C-terminal domain-like (47615)

  core: 4 helices; bundle, closed, left-handed twist; right-handed superhelix

• Methionine synthase domain-like (47643)

  4 helices; bundle, left-handed twist; right-handed superhelix

• KaiA/RbsU domain (101214)

  4 helices; bundle, right-handed twist; right-handed superhelix

• STAT-like (47654)

  4 long helices; bundle, left-handed twist (coiled coil); right-handed superhelix

• N-cbl like (47667)

  4 helices; bundle, left-handed twist; left-handed superhelix

• Replisome organizer (g39p helicase loader/inhibitor protein) (89063)

  4 helices; bundle, right-handed twist; left-handed superhelix

• Hypothetical protein YqbG (116914)

  core: 4 helices; bundle, right-handed twist; left-handed superhelix

• C-terminal domain of B transposition protein (47680)

  4 helices; irregular array

• HAND domain of the nucleosome remodeling ATPase ISWI (101223)

  4 helices; irregular array

• N-terminal, cytoplasmic domain of anti-sigmaE factor RseA (89068)

  4 helices; irregular array

• Anaphylotoxins (complement system) (47685)

  4 helices; irregular array, disulfide-linked

• Cytochrome c oxidase subunit h (47693)

  4 helices; irregular array, disulfide-linked

• Crustacean CHH/MIH/GIH neurohormone (81777)

  4 helices; irregular array, disulfide-linked

• C-terminal domain of DFF45/ICAD (DFF-C domain) (81782)

  4 helices; folded leaf; right-handed superhelix

• Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin (47698)

  4 helices; folded leaf; right-handed superhelix

• p53 tetramerization domain (47718)

  core: 4 helices; bundle

• Bcr-Abl oncoprotein oligomerization domain (69035)

  core: 4 long helices; bundle

• Domain of early E2A DNA-binding protein, ADDBP (47723)

  4 helices; bundle, partly opened

• IHF-like DNA-binding proteins (47728)

  core: 4 helices; bundle, partly opened, capped with a beta-sheet

• TraM-like (140580)

  multihelical oligomeric protein; structure of whole subunit is not known; the N-terminal part is implicated in DNA binding, the middle region forms tetrameric parallel coiled coil, surrounded by the C-terminal helices

• CO dehydrogenase ISP C-domain like (47740)

  core: 4 helices, bundle

• Protein HNS-dependent expression A; HdeA (47751)

  4 helices; the three last helices form a bundle similar to that of the RuvA C-domain

• PABP domain-like (63569)

  4 helices; an orthogonal array

• Chemotaxis receptor methyltransferase CheR, N-terminal domain (47756)

  4 helices; an orthogonal array

• Dcp2 domain-like (140585)

  4 helices; orthogonal array of two alpha hairpins

• Type III secretion system domain (140590)

  core: 4 helices, orthogonal array; right-handed superhelix

• YugE-like (116921)

  4-helices; bundle; right-handed twist

• PWI domain (101232)

  4 helices; up-and-down bundle; topological similarity to the bromodomain-like and SAM domain-like folds

• PAH2 domain (47761)

  4 helices; open up-and-down bundle; binds alpha-helical peptides

• Myosin phosphatase inhibitor 17kDa protein, CPI-17 (81789)

  4 helices; open up-and-down bundle; flexible N-terminal tail

• XPC-binding domain (101237)

  4 helices; array

• DinB/YfiT-like putative metalloenzymes (109853)

  core: 4 helices; bundle, closed, left-handed twist; an unusual topology with a higher contact order

• EspA/CesA-like (116926)

  4 helices; bundle, closed, left ight-handed twist; interlocked (hetero)dimer of 2-helical subunits

• NblA-like (109858)

  4 helices; dimer of identical alpha-hairpin subunits; open bundle

• EF2947-like (140606)

  4 helices; "diamond" array; duplication: N-terminal and C-terminal pairs of helices are related by pseudo dyad

• EB1 dimerisation domain-like (140611)

  dimeric 4-helical bundle with a coiled coil at one end formed by the longer N-terminal helices

• SAM domain-like (47768)

  4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins

• Retroviral matrix proteins (47835)

  4-5 helices; right-handed superhelix

• Flavivirus capsid protein C (101256)

  core: 5 helices; right-handed superhelix; swapped dimer with the two long C-terminal helices

• Hepatitis B viral capsid (hbcag) (47851)

  5 helices; array; two long helices form a hairpin that dimerizes into a 4-helical bundle

• Apolipophorin-III (47856)

  5 helices; bundle, closed, left-handed twist

• Methenyltetrahydrofolate cyclohydrolase-like (101261)

  5 helices; bundle, closed, left-handed twist

• A middle domain of Talin 1 (109879)

  5 helices; bundle, closed, left-handed twist; helices 2-5 adopt the Four-helical up-and-down bundle fold (scop_cf 47161)

• I/LWEQ domain (109884)

  5 helices; bundle, closed, left-handed twist

• RNA-binding protein She2p (116941)

  5 helices; bundle, closed, left-handed twist; topological similarity to the middle domain of the L-aspartase-like fold (scop_cf 48556)

• Hyaluronidase domain-like (140656)

  5 helices; bundle, closed, left-handed twist; up-and-down (meander) topology

• YoaC-like (140669)

  5 helices; bundle, one crossover connection, the arrangement of the first four helices is similar to the KaiA/RbsU domain fold (scop_cf 101214)

• Saposin-like (47861)

  5 helices; folded leaf, closed

• Annexin (47873)

  5 helices; folded leaf, closed

• Transducin (alpha subunit), insertion domain (47894)

  5 helices; folded leaf

• Wiscott-Aldrich syndrome protein, WASP, C-terminal domain (47911)

  5 helices; irregular array; left-handed superhelix

• Left-handed superhelix (47916)

  core: 4-5 helices; bundle; left-handed superhelix

• ATPD N-terminal domain-like (47927)

  core: 5 helices; bundle

• ERP29 C domain-like (47932)

  5 helices; bundle

• Functional domain of the splicing factor Prp18 (47937)

  core: 5 helices; bundle

• Retrovirus capsid protein, N-terminal core domain (47942)

  core: 5 helices; bundle

• Cyclin-like (47953)

  core: 5 helices; one helix is surrounded by the others

• Arp2/3 complex 21 kDa subunit ARPC3 (69059)

  5 helices; one helix is surrounded by the others

• RNase III domain-like (69064)

  core: 5 helices; one helix is surrounded by the others

• Ribosomal protein S7 (47972)

  core: 5 helices; contains one more helix and a beta-hairpin outside the core

• post-AAA+ oligomerization domain-like (48018)

  core: 5 helices: bundle

• PAP/OAS1 substrate-binding domain (81632)

  core: 5-helical bundle; up-and-down; right-handed twist

• Anti-sigma factor AsiA (69069)

  core: 5 helices: orthogonal array

• Antibiotic binding domain of TipA-like multidrug resistance regulators (89081)

  5 helices: orthogonal array

• Surp module (SWAP domain) (109904)

  5 helices: irregular array

• YgfY-like (109909)

  5 helices; array; forms a tight dimer in crystals

• Hypothetical protein YhaI (109914)

  core: 5 helices; orthogonal array; folding similarity to the TipA-S domain (1ny9)

• Hypothetical protein At3g22680 (109919)

  5 helices; array; probable biological unit is a homodimer

• SP0561-like (140682)

  5 helices; array; includes extra N-terminal and C-terminal short strands forming parrallel beta-sheet ladder

• YfmB-like (140687)

  5 helices, array; buried N-terminal helix; some topological similarity (circular permutation?) to the Nucleotidyltransferase substrate binding subunit/domain (scop_sf 81593)

• N-terminal domain of adenylylcyclase associated protein, CAP (101277)

  6 helices: bundle; left-handed twist, up-and-down topology

• IpaD-like (140692)

  6 helices; bundle, up-and-down; can be divided into two four-helical bundles sharing two helices (3 and 6), which are twice longer than the rest

• Iron-dependent repressor protein, dimerization domain (47978)

  6 helices, homodimer of 3-helical domains

• Glutamyl tRNA-reductase dimerization domain (69074)

  6 helices, homodimer of 3-helical domains

• GRIP domain (101282)

  6 helices, homodimer of 3-helical domains

• BAR/IMD domain-like (116747)

  6 helices, homodimer of 3-helical domains

• L27 domain (101287)

  6 helices, heterodimer of 3-helical domains

• Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain (109924)

  dimer of 3-helical segments; consists of two subdomains: 4-helical bundle and coiled coil

• Phage replication organizer domain (140712)

  6 helices, homodimer of 3-helical domains

• Mediator hinge subcomplex-like (140717)

  6 helices; heterodimer of structurally similar subunits; the N-terminal hairpins form a four-helical bundle, whereas the C-terminal helices form coiled coil structure

• DEATH domain (47985)

  6 helices: closed bundle; greek-key; internal pseudo twofold symmetry

• GntR ligand-binding domain-like (48007)

  core: 6 helices: closed bundle; greek-key; internal pseudo twofold symmetry

• AF0941-like (140725)

  6 helices, arranged into two interconnected 3-helical bundles; can also be described as a 'kinked' four-helical bundle; right-handed superhelix

• NusB-like (48012)

  6 helices: bundle; one central helix is surrounded by 5 others

• YutG-like (101306)

  core: 6 helices; bundle; one central helix is surrounded by 5 others

• N-terminal domain of DnaB helicase (48023)

  6 helices: array

• Invasion protein A (SipA) , C-terminal actin binding domain (101311)

  6 helices: orthogonal array

• Guanido kinase N-terminal domain (48033)

  irregular array of 6 short helices

• Scaffolding protein gpD of bacteriophage procapsid (48044)

  core: 6 helices; one central helix is surrounded by 5 others

• Hemocyanin, N-terminal domain (48049)

  6 helices; bundle; one central helix is surrounded by 5 others

• Di-copper centre-containing domain (48055)

  multihelical

• DBL homology domain (DH-domain) (48064)

  multihelical; core: 5-helical bundle

• LigA subunit of an aromatic-ring-opening dioxygenase LigAB (48075)

  multihelical; contains compact array of 6 short helices

• RuBisCo LSMT C-terminal, substrate-binding domain (81821)

  multihelical; irregular array of long and short helices

• Methyl-coenzyme M reductase alpha and beta chain C-terminal domain (48080)

  multihelical bundle; contains buried central helix

• YcfC-like (101321)

  multihelical; contains two buried central helices

• PA2201 C-terminal domain-like (140730)

  multihelical; seven-helical bundle with buried central helix

• Rv1873-like (140735)

  multihelical; contains unusually short buried central helix

• RUN domain-like (140740)

  multihelical; 3-helical bundle similar to one half of the DEATH domain fold is flanked by two alpha-hairpins forming a four-helical bundle; the axes of the three-helical and four-helical bundles are aproximately orthogonal to each other

• SipA N-terminal domain-like (140745)

  multihelical; bundle; the last helix is buried inside the bundle

• Transcription factor STAT-4 N-domain (48091)

  multihelical; can be divided into two subdomains

• Regulator of G-protein signaling, RGS (48096)

  multihelical; consists of two all-alpha subdomains
  contains a 4-helical bundle with left-handed twist and up-and-down topology

• SopE-like GEF domain (81831)

  multihelical; consists of two all-alpha subdomains each containing a 3-helical bundle with right-handed twist

• Variable surface antigen VlsE (74747)

  multihelical; consists of two all-alpha subdomains; contains a 4-helical bundle with left-handed twist and up-and-down topology

• YgfB-like (101326)

  multihelical; consists of two tightly associated 3-helical bundles with different twists

• Hypothetical protein MTH393 (101331)

  multihelical; consists of two all-alpha subdomains; dimer

• PG0816-like (140752)

  multihelical; comprises two helical bundles, both are topologically similar to the RuvA C-terminal domain-like fold (scop_cf 46928)

• Carbamoyl phosphate synthetase, large subunit connection domain (48107)

  multihelical; consists of two all-alpha subdomains
  possible duplication: subdomains have similar topologies

• Heme-dependent peroxidases (48112)

  multihelical; consists of two all-alpha domains

• Ribosomal protein L19 (L19e) (48139)

  multihelical; consists of two different 3-helical domains connected by a long, partly helical linker

• GatB/YqeY motif (89094)

  multihelical; consists of two different alpha-helical bundles (4-helical and 3-helical)

• YfbU-like (116959)

  multihelical; consist of two subdomains; forms 24-mer with the N-terminal sudbomains packing around the 4-fold axis and the C-terminal domains interacting at the 2-fold and 3-fold axes

• Hypothetical protein MPN330 (116964)

  multihelical; consists of three different 4-helical bundles

• HD-domain/PDEase-like (109603)

  multihelical; consists of two different alpha-helical bundles

• Superantigen MAM (101343)

  multihelical; consists of two different alpha-helical bundles

• Influenza virus matrix protein M1 (48144)

  multihelical; consists of two different all-alpha subdomains, 4 helices each

• DNA-glycosylase (48149)

  multihelical; consists of two all-alpha domains

• An anticodon-binding domain of class I aminoacyl-tRNA synthetases (48162)

  multihelical; consists of two all-alpha domains

• Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) (101352)

  multihelical; consists of two all-alpha subdomains

• R1 subunit of ribonucleotide reductase, N-terminal domain (48167)

  multihelical consists of two all-alpha subdomains
  subdomain 1 (residues 10-100) is a 4-helical bundle

• BEACH domain (81836)

  multihelical, complex architecture

• Cryptochrome/photolyase FAD-binding domain (48172)

  multihelical; consists of two all-alpha subdomains

• 6-phosphogluconate dehydrogenase C-terminal domain-like (48178)

  multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry

• Uteroglobin-like (48200)

  multihelical

• alpha/alpha toroid (48207)

  multihelical; up to seven alpha-hairpins are arranged in closed circular array; there may be sequence similarities between different superfamilies

• Citrate synthase (48255)

  multihelical; consists of two all-alpha domains

• Cytochrome P450 (48263)

  multihelical

• Flagellar transcriptional activator FlhD (63591)

  multihelical; forms intertwined dimer of identical 5-helical subunits

• Ribosomal protein L7/12, oligomerisation (N-terminal) domain (48299)

  multihelical; intertwined tetramer

• Class II MHC-associated invariant chain ectoplasmic trimerization domain (48304)

  multihelical; intertwined trimer of identical 3-helical subunits

• Aldehyde ferredoxin oxidoreductase, C-terminal domains (48309)

  multihelical; consists of two all-alpha domains

• Acid phosphatase/Vanadium-dependent haloperoxidase (48316)

  multihelical; core: 5-helical bundle; binds cofactor at the beginning of third helix

• BRCA2 helical domain (81871)

  multihelical; contains a 3-helical bundle surrounded by several shorter helices

• BRCA2 tower domain (81877)

  multihelical; contains a 3-helical Hin recombinase-like subdomain and two long dimerisation helices

• H-NS histone-like proteins (81274)

  multihelical oligomeric protein; structure of whole subunit is not known yet but are probably composed of three different domains

• Sigma2 domain of RNA polymerase sigma factors (88945)

  multihelical; consists of a conserved 4-helical core and a variable insert subdomain

• DNA repair protein MutS, domain III (48333)

  multihelical; consists of 2 all-alpha subdomains

• Helical scaffold and wing domains of SecA (81885)

  multihelical; consists of 2 all-alpha subdomains

• all-alpha NTP pyrophosphatases (101385)

  multihelical: dimeric 4-helical bundle surrounded by other helices; oligomerizes further in a tetramer

• Hsp90 co-chaperone CDC37 (101390)

  multihelical; consists of 2 all-alpha subdomains connected by a long helix

• Nop domain (89123)

  multihelical; array of longer and shorter helices; contains an alpha-hairpin dimerisation subdomain

• YidB-like (140803)

  multihelical; three strings of short helices are packed across one longer helix

• Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain (48339)

  multihelical; bundle of longer and shorter helices

• A virus capsid protein alpha-helical domain (48344)

  multihelical; three-helical bundle in the core is surrounded by non-conserved helices

• P40 nucleoprotein (101398)

  multihelical; consists of two subdomains

• Rhabdovirus nucleoprotein-like (140808)

  multihelical, consist of two helical domains; each domain contains a buried helix

• GTPase activation domain, GAP (48349)

  multihelical

• Ras GEF (48365)

  multihelical

• Telomeric repeat binding factor (TRF) dimerisation domain (63599)

  multihelical; can be divided into an alpha-alpha superhelix domain and a long alpha-hairpin dimerization domain

• Poly A polymerase C-terminal region-like (81890)

  multihelical; can be divided into three subdomains (neck, body and tail)

• alpha-alpha superhelix (48370)

  multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

• GUN4-like (140868)

  multihelical; open array, trapping inside an extended region before the C-terminal helix

• Lipoxigenase (48483)

  multihelical
  large nearly all-alpha domain

• gene 59 helicase assembly protein (48492)

  multihelical; consists of two all-alpha subdomains

• Tetracyclin repressor-like, C-terminal domain (48497)

  multihelical; interlocked (homo)dimer

• Skp1 dimerisation domain-like (81384)

  multihelical; interlocked heterodimer with F-box proteins

• F-box domain (81385)

  multihelical; interlocked heterodimer with the Skp1 dimerisation domain

• Nuclear receptor ligand-binding domain (48507)

  multihelical; 3 layers or orthogonally packed helices

• Phospholipase C/P1 nuclease (48536)

  multihelical

• ATP-dependent DNA ligase DNA-binding domain (117017)

  multihelical; duplication: contains two intertwined structural repeats related by pseudo twofold symmetry

• DNA primase DnaG, C-terminal domain (117022)

  multihelical; segment-swapped dimer

• PriB N-terminal domain-like (140913)

  multihelical bundle; contains buried central helix; also includes the PriA interface-forming insert subdomain (alpha+beta)

• VPS9 domain (109992)

  multihelical; consist of two subdomains

• Triger factor/SurA peptide-binding domain-like (109997)

  multihelical; irregular array of long and short helices

• DNA terminal protein (140918)

  multihelical, open array; contains the C-terminal four-helical bundle, left-handed superhelix

• Glycolipid transfer protein, GLTP (110003)

  multihelical; 2 layers or orthogonally packed helices

• Hypothetical protein MG354 (110008)

  multihelical bundle; contains buried central helix

• Duffy binding domain-like (140923)

  consist of two subdomains, each containing a three-helical bundle

• Fic-like (140930)

  multihelical; one central helix is surrounded by seven helices

• Her-1 (110013)

  multihelical; consists of two topologically similar alpha-helical bundles

• ERO1-like (110018)

  multihelical; consists of 2 four-helical bundles

• Serum albumin-like (48551)

  multihelical; one domain consists of two similar disulfide-linked subdomains

• L-aspartase-like (48556)

  multihelical, consists of three all-alpha domains

• Formin homology 2 domain (FH2 domain) (101446)

  multihelical, consists of three all-alpha domains

• Terpenoid synthases (48575)

  multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

• GroEL equatorial domain-like (48591)

  multihelical; 8 helices arranged in 2 parallel layers

• TorD-like (89154)

  multihelical; bundle

• Chorismate mutase II (48599)

  multihelical; core: 6 helices, bundle

• Peridinin-chlorophyll protein (48607)

  multihelical: forms a boat-shaped protein shell around cofactors

• Heme oxygenase-like (48612)

  multihelical; bundle

• Indolic compounds 2,3-dioxygenase-like (140958)

  multihelical; bundle, contains interrupted helices

• AhpD-like (69117)

  multihelical; contains 4-helical bundle and 2-helical arm

• Double Clp-N motif (81922)

  multihelical; array

• Orange carotenoid protein, N-terminal domain (81929)

  multihelical; array

• DhaL-like (101472)

  multihelical; bundle

• ADP-ribosylglycohydrolase (101477)

  multihelical; bundle

• Topoisomerase V catalytic domain-like (140978)

  multihelical; irregular array; contains small amount of beta-structure and a 3-helical bundle with a variant homeofomain-like fold and HTH motif (scop_cf 46688)

• PTPA-like (140983)

  multihelical

• FtsH protease domain-like (140989)

  array of 6 helices and a 2-stranded beta-ribbon

• Gametocyte protein Pfg27 (89161)

  multihelical; bundle

• N-terminal domain of bifunctional PutA protein (81934)

  multihelical; array

• Cysteine alpha-hairpin motif (47071)

  core: alpha-hairpin crosslinked with two disulfides

• Phospholipase A2, PLA2 (48618)

  common core: 2 helices, disulfide-linked, and a calcium-binding loop

• Fungal elicitin (48646)

  5 helices: irregular disulfide-linked array; also contains a small beta-hairpin

• Tetraspanin (48651)

  5 helices: irregular disulfide-linked array; form homodimer

• GDNF receptor-like (110034)

  5 helices: irregular disulfide-linked array; topological similarity to the Fungal elicitin fold (scop_cf 48646)

• FinO-like (48656)

  6 helices: irregular non-globular array; also contains two small beta-hairpins

• Nuclear receptor coactivator interlocking domain (69124)

  3 helices, non-globular array; forms interlocked heterodimers with its targets

• Hermes dimerisation domain (140995)

  multihelical, intertwinned dimer of two 4-helical strings

• Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain (101488)

  5 helices, non-globular array; wraps around the N-terminal tail of its target

• Non-globular all-alpha subunits of globular proteins (48661)

  not a true fold

• Multiheme cytochromes (48694)

  variable number of helices and little beta structure; not a true fold